Heme as a differentiation-regulatory transcriptional cofactor

Translational control by heme-regulated eIF2α kinase during erythropoiesis

(2022) Jane-Jane Chen et al.   CURRENT OPINION IN HEMATOLOGY

Molecular Mechanisms of Iron and Heme Metabolism

(2022) Sohini Dutt et al.   Annual Review of Nutrition

The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding

(2022) Kei Segawa et al.   FEBS LETTERS

Discovering How Heme Controls Genome Function Through Heme-omics

(2020) Ruiqi Liao et al.   Cell Reports

GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism

(2020) Nicole M. Zwifelhofer et al.   PLoS Genetics

HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

(2019) Shuping Zhang et al.   eLife

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

(2019) Salil Saurav Pathak et al.   NEURON

GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism

(2018) Nobuyuki Tanimura et al.   DEVELOPMENTAL CELL

Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

(2018) Hiroki Kato et al.   NATURE IMMUNOLOGY

Single cell analyses demonstrate that a heme - GATA1 feedback loop regulates red cell differentiation

(2018) Raymond T. Doty et al.   BLOOD

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Orchestration of B lymphoid cells and their inner myeloid by Bach

(2016) Kazuhiko Igarashi et al.   CURRENT OPINION IN IMMUNOLOGY

Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Ppargpathway in adipogenesis

(2016) Mitsuyo Matsumoto et al.   GENES TO CELLS

The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis

(2016) Risa Ebina-Shibuya et al.   JOURNAL OF BIOCHEMISTRY

­­LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

(2016) Julia Zinngrebe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation

(2016) Yingchi Zhang et al.   NUCLEIC ACIDS RESEARCH

Heme binds to an intrinsically disordered region of Bach2 and alters its conformation

(2015) Miki Watanabe-Matsui et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation

(2015) Nobuyuki Tanimura et al.   EMBO REPORTS

Coordinate expression of heme and globin is essential for effective erythropoiesis

(2015) Raymond T. Doty et al.   JOURNAL OF CLINICAL INVESTIGATION

X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations

(2013) Dean R. Campagna et al.   AMERICAN JOURNAL OF HEMATOLOGY

Heme transport and erythropoiesis

(2013) Xiaojing Yuan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia

(2013) K. Kaneko et al.   HAEMATOLOGICA

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover

(2013) Meng-Kwang Marcus Tan et al.   MOLECULAR CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Erythroid Heme Biosynthesis and Its Disorders

(2013) H. A. Dailey et al.   Cold Spring Harbor Perspectives in Medicine

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

An encyclopedia of mouse DNA elements (Mouse ENCODE)

(2012) et al.   GENOME BIOLOGY

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2

(2011) M. Watanabe-Matsui et al.   BLOOD

The BTB and CNC Homology 1 (BACH1) Target Genes Are Involved in the Oxidative Stress Response and in Control of the Cell Cycle

(2011) Hans-Jörg Warnatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZNF274 Recruits the Histone Methyltransferase SETDB1 to the 3′ Ends of ZNF Genes

(2010) Seth Frietze et al.   PLoS One

Elucidation of the Heme Binding Site of Heme-regulated Eukaryotic Initiation Factor 2α Kinase and the Role of the Regulatory Motif in Heme Sensing by Spectroscopic and Catalytic Studies of Mutant Proteins

(2008) Jotaro Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE