The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics

Qualitative Research in CKD: How to Appraise and Interpret the Evidence

(2021) Amanda Baumgart et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Downregulated Serum Exosomal miR-451a Expression Correlates With Renal Damage and Its Intercellular Communication Role in Systemic Lupus Erythematosus

(2021) Lina Tan et al.   Frontiers in Immunology

The exosome journey: from biogenesis to uptake and intracellular signalling

(2021) Sonam Gurung et al.   Cell Communication and Signaling

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation

(2021) Wenqian Wei et al.   Stem Cell Research & Therapy

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing

(2021) Li Duan et al.   Frontiers in Genetics

Serum Derived Extracellular Vesicles Mediated Delivery of Synthetic miRNAs in Human Endothelial Cells

(2021) Marta Tapparo et al.   Frontiers in Molecular Biosciences

Application of mesenchymal stem cell-derived exosomes in kidney diseases

(2021) Deng Gang et al.   CELLULAR IMMUNOLOGY

Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

(2021) Li Duan et al.   CHEMBIOCHEM

Kidney stone proteomics: an update and perspectives

(2021) Paleerath Peerapen et al.   Expert Review of Proteomics

CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular Vesicles

(2021) Katarzyna Horodecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles as a Therapeutic Tool for Kidney Disease: Current Advances and Perspectives

(2021) Raphael Rodrigues Corrêa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles in Acute Kidney Injury and Clinical Applications

(2021) Sekyung Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes: Emerging Therapy Delivery Tools and Biomarkers for Kidney Diseases

(2021) Can Jin et al.   Stem Cells International

A Pilot Study to Predict Risk of IgA Nephropathy Progression Based on miR-204 Expression

(2021) Izabella Pawluczyk et al.   Kidney International Reports

Editorial: Immunity and Inflammatory Response in Kidney Stone Disease

(2021) Visith Thongboonkerd et al.   Frontiers in Immunology

Human umbilical cord mesenchymal stem cell exosomes alleviate sepsis-associated acute kidney injury via regulating microRNA-146b expression

(2020) Rongxue Zhang et al.   BIOTECHNOLOGY LETTERS

Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent

(2020) Joo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Urinary Exosomal miRNA Expression Profile is Predictive of Clinical Response in Lupus Nephritis

(2020) Eloi Garcia-Vives et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin‐stimulated exosomes enhance the regenerative potential of chronic kidney disease‐derived mesenchymal stem/stromal cells via cellular prion proteins

(2020) Yeo Min Yoon et al.   JOURNAL OF PINEAL RESEARCH

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Roles for Exosome in Various Kidney Diseases and Disorders

(2020) Visith Thongboonkerd   Frontiers in Pharmacology

Identification of differentially expressed circulating exosomal lncRNAs in IgA nephropathy patients

(2020) Na Guo et al.   BMC IMMUNOLOGY

Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

(2020) Jingyuan Cao et al.   Stem Cell Research & Therapy

miR-451 Loaded Exosomes Are Released by the Renal Cells in Response to Injury and Associated With Reduced Kidney Function in Human

(2020) Manju Kumari et al.   Frontiers in Physiology

CASK, the Soluble Glomerular Permeability Factor, Is Secreted by Macrophages in Patients With Recurrent Focal and Segmental Glomerulo—Sclerosis

(2020) Xiaomeng Zhang et al.   Frontiers in Immunology

LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer

(2020) Chengming Sun et al.   Aging-US

Extracellular vesicles carrying miRNAs in kidney diseases: a systemic review

(2020) Wei Zhang et al.   Clinical and Experimental Nephrology

Injured tubular epithelial cells activate fibroblasts to promote kidney fibrosis through miR-150-containing exosomes

(2020) Han Guan et al.   EXPERIMENTAL CELL RESEARCH

Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

(2020) Tânia Soares Martins et al.   JOURNAL OF NEUROCHEMISTRY

Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway

(2020) Honglian Li et al.   Frontiers in Pharmacology

An exosome pathway without an ESCRT

(2020) Candia M. Kenific et al.   CELL RESEARCH

Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis

(2020) Javier Perez-Hernandez et al.   JOURNAL OF NEPHROLOGY

Early Detection of CKD: Implications for Low-Income, Middle-Income, and High-Income Countries

(2020) Marcello Tonelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage interactions with collecting duct epithelial cells are capable of driving tubulointerstitial inflammation and fibrosis in immunoglobulin A nephropathy

(2020) Izabella Z A Pawluczyk et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Quantitative proteomic analysis of urinary exosomes in kidney stone patients

(2020) Qing Wang et al.   Translational Andrology and Urology

Differential Expression of Urinary Exosomal Small RNAs in Idiopathic Membranous Nephropathy

(2020) Jinshi Zhang et al.   Biomed Research International

Ischemic Duration and Frequency Determines AKI-to-CKD Progression Monitored by Dynamic Changes of Tubular Biomarkers in IRI Mice

(2019) Yang Dong et al.   Frontiers in Physiology

Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems

(2019) Vitale Miceli et al.   Stem Cells International

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Bone marrow mesenchymal stem cell–derived exosomes alleviate high phosphorus-induced vascular smooth muscle cells calcification by modifying microRNA profiles

(2019) Yan Guo et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease

(2019) Krishnamurthy P. Gudehithlu et al.   Clinical and Experimental Nephrology

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Exosome manufacturing status

(2019) William Whitford et al.   Future Medicinal Chemistry

An Exosomal Urinary miRNA Signature for Early Diagnosis of Renal Fibrosis in Lupus Nephritis

(2019) Solé et al.   Cells

Exosomes from miR‐20b‐3p‐overexpressing stromal cells ameliorate calcium oxalate deposition in rat kidney

(2019) Jing Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats

(2019) Lixia Bai et al.   BIOCHEMICAL PHARMACOLOGY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life in the lumen: The multivesicular endosome

(2019) Jean Gruenberg   TRAFFIC

Distinct non-invasive evaluation values of tumor-derived cell-free microRNAs, circulating microvesicles and exosomal microRNAs after renal carcinoma cryoablation

(2018) Jie Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application

(2018) Takuma Yamashita et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Potential Value of Urinary Exosome-Derived let-7c-5p in the Diagnosis and Progression of Type II Diabetic Nephropathy

(2018) Weite Li et al.   Clinical Laboratory

A PEG-based method for the isolation of urinary exosomes and its application in renal fibrosis diagnostics using cargo miR-29c and miR-21 analysis

(2018) Chun-yan Lv et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix

(2018) Nilubon Singhto et al.   Journal of Proteomics

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

(2018) Lin-Li Lv et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

(2018) Giulia Furini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

(2018) Luisa Statello et al.   PLoS One

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

(2018) Fruzsina Hobor et al.   Nature Communications

miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk

(2018) Aiqing Zhang et al.   Journal of Cachexia Sarcopenia and Muscle

Roles of Macrophage Exosomes in Immune Response to Calcium Oxalate Monohydrate Crystals

(2018) Nilubon Singhto et al.   Frontiers in Immunology

Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy

(2018) Ye Feng et al.   AMERICAN JOURNAL OF PATHOLOGY

Exosomes produced from three-dimensional cultures of mesenchymal stem cells by tangential flow filtration show higher yield and improved activity

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

hsa-miR-500a-3P alleviates kidney injury by targeting MLKL-mediated necroptosis in renal epithelial cells

(2018) Ling Jiang et al.   FASEB JOURNAL

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Prospects for proteomics in kidney stone disease

(2017) Arada Vinaiphat et al.   Expert Review of Proteomics

Differential expression of urinary exosomal microRNAs in IgA nephropathy

(2017) Qing-Hua Min et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks

(2017) Paul Pang et al.   KIDNEY INTERNATIONAL

Extracellular vesicles in renal disease

(2017) Diana Karpman et al.   Nature Reviews Nephrology

Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury

(2017) Tanaporn Panich et al.   BMC Nephrology

Alteration of exosomes secreted from renal tubular epithelial cells exposed to high-concentration oxalate

(2017) Ziqi He et al.   Oncotarget

Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway

(2017) Yang Xia et al.   Oncotarget

Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation

(2017) Fengming Zhu et al.   Oncotarget

Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes

(2017) Xiaoming Wu et al.   Scientific Reports

Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy

(2017) Bingying Wang et al.   Stem Cell Research & Therapy

Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy

(2017) Luigi Rossi et al.   Journal of Diabetes Research

Clinical verification of a novel urinary microRNA panal: 133b, -342 and -30 as biomarkers for diabetic nephropathy identified by bioinformatics analysis

(2016) Sanaa Eissa et al.   BIOMEDICINE & PHARMACOTHERAPY

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Combination of adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes for protecting kidney from acute ischemia–reperfusion injury

(2016) Kun-Chen Lin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Urinary exosomal microRNA panel unravels novel biomarkers for diagnosis of type 2 diabetic kidney disease

(2016) Sanaa Eissa et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Transfer of microRNA-486-5p from human endothelial colony forming cell–derived exosomes reduces ischemic kidney injury

(2016) Jose L. Viñas et al.   KIDNEY INTERNATIONAL

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease

(2016) Rimpi Khurana et al.   RNA

Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond

(2016) Kerstin Klinkert et al.   TRAFFIC

PLK-1 Silencing in Bladder Cancer by siRNA Delivered With Exosomes

(2016) Kristin A. Greco et al.   UROLOGY

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

(2016) Zhen-zhen Jiang et al.   Stem Cell Research & Therapy

Urinary Exosomal microRNA-451-5p Is a Potential Early Biomarker of Diabetic Nephropathy in Rats

(2016) Aradhana Mohan et al.   PLoS One

Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes

(2016) Kanna Nagaishi et al.   Scientific Reports

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine

(2015) Krishnamurthy P. Gudehithlu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury

(2015) Dylan Burger et al.   AMERICAN JOURNAL OF PATHOLOGY

Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity

(2015) Romina Paula Bulacio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3

(2015) Jianjun Diao et al.   MEDICAL ONCOLOGY

Proteomics characterization of exosome cargo

(2015) Kevin L. Schey et al.   METHODS

Improved Structure and Function in Autosomal Recessive Polycystic Rat Kidneys with Renal Tubular Cell Therapy

(2015) K. J. Kelly et al.   PLoS One

Exosomal ATF3 RNA Attenuates Pro-Inflammatory Gene MCP-1 Transcription in Renal Ischemia-Reperfusion

(2014) Hsi-Hsien Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of Biomarkers for PKD1 Using Urinary Exosomes

(2014) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CD2AP mRNA in urinary exosome as biomarker of kidney disease

(2013) Lin-Li Lv et al.   CLINICA CHIMICA ACTA

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition

(2013) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Urinary exosomes and diabetic nephropathy: a proteomic approach

(2013) F. Raimondo et al.   Molecular BioSystems

Differential protein profiling of renal cell carcinoma urinary exosomes

(2013) F. Raimondo et al.   Molecular BioSystems

The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule

(2013) LONG ZHANG et al.   Molecular Medicine Reports

Urinary Exosomes as a Source of Kidney Dysfunction Biomarker in Renal Transplantation

(2013) S. Alvarez et al.   TRANSPLANTATION PROCEEDINGS

Renal Carcinoma Cell-Derived Exosomes Induce Human Immortalized Line of Jurkat T Lymphocyte Apoptosis in vitro

(2013) Lin Yang et al.   UROLOGIA INTERNATIONALIS

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

(2013) Ying Zhou et al.   Stem Cell Research & Therapy

A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: Application to RCC urinary exosomes

(2012) Piero Del Boccio et al.   ELECTROPHORESIS

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bone Marrow-Derived Mesenchymal Stem Cells Repaired but Did Not Prevent Gentamicin-Induced Acute Kidney Injury through Paracrine Effects in Rats

(2012) Luciana A. Reis et al.   PLoS One

Application of systems biology principles to protein biomarker discovery: Urinary exosomal proteome in renal transplantation

(2012) Trairak Pisitkun et al.   Proteomics Clinical Applications

Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells

(2012) Susanna Tomasoni et al.   STEM CELLS AND DEVELOPMENT

Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy

(2011) Pyong-Gon Moon et al.   PROTEOMICS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Urinary exosomal transcription factors, a new class of biomarkers for renal disease

(2008) Hua Zhou et al.   KIDNEY INTERNATIONAL