Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diffuse Alveolar Hemorrhage Associated with Systemic Lupus Erythematosus in Mice by Promoting M2 Macrophage Polarization via the microRNA-146a-5p/NOTCH1 Axis

HucMSC exosomes promoted imatinib-induced apoptosis in K562-R cells via a miR-145a-5p/USP6/GLS1 axis

(2022) Xiaowen Chen et al.   Cell Death & Disease

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

(2021) Zhongfei Zhang et al.   Aging-US

Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis

(2021) Zhongnan Yang et al.   JOURNAL OF IMMUNOLOGY

Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage

(2021) Yi-Cheng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

(2021) Mariame Mohamed Ahamada et al.   Frontiers in Immunology

HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice

(2020) Weijie Yang et al.   MOLECULAR THERAPY

Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways

(2020) Peitao Zhou et al.   Frontiers in Cell and Developmental Biology

The circRNA–miRNA–mRNA regulatory network in systemic lupus erythematosus

(2020) Junhui Zhang et al.   CLINICAL RHEUMATOLOGY

Notch1 in Cancer Therapy: Possible Clinical Implications and Challenges

(2020) L. Gharaibeh et al.   MOLECULAR PHARMACOLOGY

LINC00612/miR-31-5p/Notch1 Axis Regulates Apoptosis, Inflammation, and Oxidative Stress in Human Pulmonary Microvascular Endothelial Cells Induced by Cigarette Smoke Extract

(2020) Jun Luo et al.   International Journal of Chronic Obstructive Pulmonary Disease

miR‐146a‐5p: Expression, regulation, and functions in cancer

(2019) Joseph R. Iacona et al.   Wiley Interdisciplinary Reviews-RNA

Exosomes in cancer development, metastasis, and immunity

(2019) Lin Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Upregulation of microRNA‐27a inhibits synovial angiogenesis and chondrocyte apoptosis in knee osteoarthritis rats through the inhibition of PLK2

(2019) Wenjing Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Involvement of miR-146a-5p/neurogenic locus notch homolog protein 1 in the proliferation and differentiation of STRO-1+ human dental pulp stem cells

(2019) Zailing Qiu et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization

(2019) Chetan P. Hans et al.   Scientific Reports

Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

(2019) Yoda Yaghoubi et al.   LIFE SCIENCES

Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge

(2019) Hao Zhang et al.   Scientific Reports

Implications of macrophage polarization in autoimmunity

(2018) Samanta C. Funes et al.   IMMUNOLOGY

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

(2018) Chiraz Atri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages

(2018) Shuhong Han et al.   Frontiers in Immunology

Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus

(2018) Li Zeng et al.   CLINICAL IMMUNOLOGY

Exosomes derived from human umbilical cord mesenchymal stem cells accelerate growth of VK2 vaginal epithelial cells through MicroRNAs in vitro

(2018) Zhongyi Zhu et al.   HUMAN REPRODUCTION

Clinical characteristics and outcomes of diffuse alveolar hemorrhage in patients with systemic lupus erythematosus

(2017) Dam Kim et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus

(2017) Haoyang Zhuang et al.   Arthritis & Rheumatology

Recent advances of exosomes in immune modulation and autoimmune diseases

(2016) Lina Tan et al.   AUTOIMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages

(2016) Cheng Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus

(2016) Xiaojing Li et al.   Cell Death & Disease

Inhibiting Notch-1 reduces the expression of Toll-like receptor 9 in BABL/C-lpr mouse kidneys and improves glucocorticoid sensitivity

(2015) GONG XIAO et al.   Molecular Medicine Reports

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

cAMP-responsive Element Modulator α (CREMα) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE)

(2012) Thomas Rauen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Defects in Notch1 upregulation upon activation of T Cells from patients with systemic lupus erythematosus are related to lupus disease activity

(2008) P Sodsai et al.   LUPUS