A phase 2, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox–Gastaut syndrome ( ELEKTRA )

Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers

(2022) Shining Wang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies

(2021) Adam Strzelczyk et al.   CNS DRUGS

Safety, tolerability, pharmacokinetics, pharmacodynamics, bioavailability and food effect of single doses of soticlestat in healthy subjects

(2021) Shining Wang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A phase 1b/2a study of soticlestat as adjunctive therapy in participants with developmental and/or epileptic encephalopathies

(2021) Jonathan J. Halford et al.   EPILEPSY RESEARCH

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

(2020) Toshiya Nishi et al.   Scientific Reports

Treatment Strategies for Dravet Syndrome

(2018) Kelly G. Knupp et al.   CNS DRUGS

Few individuals with Lennox-Gastaut syndrome have autism spectrum disorder: a comparison with Dravet syndrome

(2018) Na He et al.   Journal of Neurodevelopmental Disorders

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Early Diagnosis and Treatment of Lennox-Gastaut Syndrome

(2017) Trevor Resnick et al.   JOURNAL OF CHILD NEUROLOGY

Lennox-Gastaut syndrome: a comprehensive review

(2017) Ali A. Asadi-Pooya   NEUROLOGICAL SCIENCES

Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel

(2017) Elaine C. Wirrell et al.   PEDIATRIC NEUROLOGY

Expert Opinion on the Management of Lennox–Gastaut Syndrome: Treatment Algorithms and Practical Considerations

(2017) J. Helen Cross et al.   Frontiers in Neurology

Epilepsy diagnostic and treatment needs identified with a collaborative database involving tertiary centers in France

(2016) Mathilde Chipaux et al.   EPILEPSIA

Pharmacotherapy for Dravet Syndrome

(2016) Adam Wallace et al.   PEDIATRIC DRUGS

Long-term prognosis of patients with Lennox–Gastaut syndrome in recent decades

(2015) Hyo Jeong Kim et al.   EPILEPSY RESEARCH

Medical management of refractory epilepsy-Practical treatment with novel antiepileptic drugs

(2014) Elinor Ben-Menachem   EPILEPSIA

Lennox-Gastaut syndrome: A consensus approach to differential diagnosis

(2014) Blaise F. D. Bourgeois et al.   EPILEPSIA

The core Dravet syndrome phenotype

(2011) Charlotte Dravet   EPILEPSIA

Comorbidities and predictors of health-related quality of life in Dravet syndrome

(2011) Andreas Brunklaus et al.   EPILEPSIA

Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome

(2011) Y. T. Ng et al.   NEUROLOGY

Child Neurology: Dravet syndrome: When to suspect the diagnosis

(2009) J. J. Millichap et al.   NEUROLOGY

Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: Literature review

(2009) Katy Gallop et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Lennox-Gastaut Syndrome (LGS): Development of conceptual models of health-related quality of life (HRQL) for caregivers and children

(2009) Katy Gallop et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Clobazam in the treatment of Lennox-Gastaut syndrome

(2008) Joan A. Conry et al.   EPILEPSIA