Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies

Adjunctive Cannabidiol in Patients with Dravet Syndrome: A Systematic Review and Meta-Analysis of Efficacy and Safety

(2020) Simona Lattanzi et al.   CNS DRUGS

A systematic review on the burden of illness in individuals with tuberous sclerosis complex (TSC)

(2020) Johann Philipp Zöllner et al.   Orphanet Journal of Rare Diseases

Stereotactic laser anterior corpus callosotomy for Lennox‐Gastaut syndrome

(2020) James X. Tao et al.   EPILEPSIA

Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta‐analysis

(2020) Laura Lyons et al.   EPILEPSIA

Cannabidiol efficacy and clobazam status: A systematic review and meta‐analysis

(2020) Simona Lattanzi et al.   EPILEPSIA

Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials

(2020) Meir Bialer et al.   EPILEPSIA

Fenfluramine acts as a positive modulator of sigma-1 receptors

(2020) Parthena Martin et al.   EPILEPSY & BEHAVIOR

Epilepsy: key experimental therapeutics in early clinical development

(2020) Claude Steriade et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lennox-Gastaut syndrome: New treatments and treatments under investigation

(2020) S. Auvin   REVUE NEUROLOGIQUE

Expert opinion: Proposed diagnostic and treatment algorithms for Lennox–Gastaut syndrome in adult patients

(2020) Georgia Montouris et al.   EPILEPSY & BEHAVIOR

Cenobamate for the treatment of focal epilepsies

(2020) Adam Strzelczyk et al.   EXPERT OPINION ON PHARMACOTHERAPY

Therapeutic advances in Dravet syndrome: a targeted literature review

(2020) Adam Strzelczyk et al.   Expert Review of Neurotherapeutics

Epidemiology, healthcare resource use, and mortality in patients with probable Lennox-Gastaut syndrome: A population-based study on German health insurance data

(2020) Adam Strzelczyk et al.   EPILEPSY & BEHAVIOR

Anterior Corpus Callosotomy Using Laser Interstitial Thermal Therapy for Refractory Epilepsy

(2019) Tyler Ball et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Corpus callosotomy via laser interstitial thermal therapy: a case series

(2019) Atilio E. Palma et al.   Journal of Neurosurgery-Pediatrics

Long-term safety and efficacy of cannabidiol in children and adults with treatment-resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results

(2019) Linda C. Laux et al.   EPILEPSY RESEARCH

Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study

(2019) Elizabeth Thiele et al.   EPILEPSIA

Therapeutic approach to Lennox–Gastaut syndrome: a systematic review

(2019) Serena Borrelli et al.   ACTA NEUROLOGICA BELGICA

Effects of cannabidiol on brivaracetam plasma levels

(2019) Kerstin A. Klotz et al.   EPILEPSIA

Recent advances in the pharmacotherapy of epilepsy: brivaracetam and perampanel as broad-spectrum antiseizure drugs for the treatment of epilepsies and status epilepticus

(2019) Laurent Maximilian Willems et al.   EXPERT OPINION ON PHARMACOTHERAPY

Drug–drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures

(2019) Pavel Klein et al.   EPILEPSY & BEHAVIOR

Seizure management and prescription patterns of anticonvulsants in Dravet syndrome: A multicenter cohort study from Germany and review of literature

(2019) Susanne Schubert-Bast et al.   EPILEPSY & BEHAVIOR

Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach

(2019) Kurt R. Lehner et al.   JOURNAL OF NEUROSURGERY

Stereotactic laser ablation for completion corpus callosotomy

(2019) Yuhao Huang et al.   Journal of Neurosurgery-Pediatrics

Treatment with brivaracetam in children – The experience of a pediatric epilepsy center

(2019) Andreea Nissenkorn et al.   EPILEPSY & BEHAVIOR

Corpus callosotomy performed with laser interstitial thermal therapy

(2019) Jarod L. Roland et al.   JOURNAL OF NEUROSURGERY

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

(2019) Lieven Lagae et al.   LANCET

Open-label, uncontrolled retrospective study of perampanel in adults with Lennox-Gastaut syndrome

(2019) Arielle Crespel et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Optimizing clobazam treatment in patients with Lennox–Gastaut syndrome

(2018) Jouko Isojarvi et al.   EPILEPSY & BEHAVIOR

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

OUP accepted manuscript

(2018)   NEUROSURGERY

Anterior two-thirds corpus callosotomy via stereotactic laser ablation

(2018) Michael Karsy et al.   Neurosurgical Focus

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rufinamide efficacy and safety in children aged 1–4 years with Lennox–Gastaut syndrome

(2018) Shin Hye Kim et al.   BRAIN & DEVELOPMENT

Cognitive benefits of the ketogenic diet in patients with epilepsy: A systematic overview

(2018) Annemiek A. van Berkel et al.   EPILEPSY & BEHAVIOR

Burden of illness in patients with possible Lennox–Gastaut syndrome: A retrospective claims-based study

(2018) Nancy L. Reaven et al.   EPILEPSY & BEHAVIOR

Individualized treatment approaches: Fenfluramine, a novel antiepileptic medication for the treatment of seizures in Dravet syndrome

(2018) Tilman Polster   EPILEPSY & BEHAVIOR

Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to

(2018) Alexis Arzimanoglou et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome

(2018) Joon Won Kang et al.   PEDIATRICS

Efficacy, Retention, and Tolerability of Brivaracetam in Patients With Epileptic Encephalopathies: A Multicenter Cohort Study From Germany

(2018) Laurent M. Willems et al.   Frontiers in Neurology

BRIVA-LIFE-A multicenter retrospective study of the long-term use of brivaracetam in clinical practice

(2018) Vicente Villanueva et al.   ACTA NEUROLOGICA SCANDINAVICA

A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a 
regimen of stiripentol, clobazam, and valproate in healthy subjects

(2018) Brooks Boyd et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

The pharmacological management of Lennox-Gastaut syndrome and critical literature review

(2018) Alberto Verrotti et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Corpus callosotomy-Open and endoscopic surgical techniques

(2017) Matthew D. Smyth et al.   EPILEPSIA

Interactions between cannabidiol and commonly used antiepileptic drugs

(2017) Tyler E. Gaston et al.   EPILEPSIA

Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany

(2017) Isabel Steinig et al.   EPILEPSIA

A two-year retrospective evaluation of perampanel in patients with highly drug-resistant epilepsy and cognitive impairment

(2017) Bernd Huber et al.   EPILEPSY & BEHAVIOR

Real-world data on rufinamide treatment in patients with Lennox–Gastaut syndrome: Results from a European noninterventional registry study

(2017) Marina Nikanorova et al.   EPILEPSY & BEHAVIOR

Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues

(2017) R. Nabbout et al.   EPILEPSY & BEHAVIOR

Assessment of treatment patterns and healthcare costs associated with probable Lennox–Gastaut syndrome

(2017) J. Eric Piña-Garza et al.   EPILEPSY & BEHAVIOR

Use of perampanel in children and adolescents with Lennox–Gastaut Syndrome

(2017) Stéphane Auvin et al.   EPILEPSY & BEHAVIOR

Treatment of Epileptic Encephalopathies: Current State of the Art

(2017) Hiroki Nariai et al.   JOURNAL OF CHILD NEUROLOGY

Early Diagnosis and Treatment of Lennox-Gastaut Syndrome

(2017) Trevor Resnick et al.   JOURNAL OF CHILD NEUROLOGY

Ketone Bodies as Anti-Seizure Agents

(2017) Timothy A. Simeone et al.   NEUROCHEMICAL RESEARCH

Lennox-Gastaut syndrome: a comprehensive review

(2017) Ali A. Asadi-Pooya   NEUROLOGICAL SCIENCES

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish

(2017) Jo Sourbron et al.   Frontiers in Pharmacology

Expert Opinion on the Management of Lennox–Gastaut Syndrome: Treatment Algorithms and Practical Considerations

(2017) J. Helen Cross et al.   Frontiers in Neurology

Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience

(2016) Yash D. Shah et al.   EPILEPSY & BEHAVIOR

Long-term safety and seizure outcome in Japanese patients with Lennox–Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial

(2016) Yoko Ohtsuka et al.   EPILEPSY RESEARCH

Therapeutic effects of the ketogenic diet in children with Lennox-Gastaut syndrome

(2016) Yunjian Zhang et al.   EPILEPSY RESEARCH

Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study

(2016) Alexis Arzimanoglou et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Corpus callosotomy versus vagus nerve stimulation for atonic seizures and drop attacks: A systematic review

(2015) John D. Rolston et al.   EPILEPSY & BEHAVIOR

Effectiveness of a hybrid corticosteroid treatment regimen on refractory childhood seizures and a review of other corticosteroid treatments

(2015) Dewi P. Bakker et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

The rise and fall of felbamate as a treatment for partial epilepsy – aplastic anemia and hepatic failure to blame?

(2015) Karan Thakkar et al.   Expert Review of Neurotherapeutics

The ketogenic diet in pharmacoresistant childhood epilepsy

(2015) Steven Parrish Winesett et al.   Expert Review of Neurotherapeutics

Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis

(2015) Fang Ye et al.   Journal of Clinical Neurology

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effectiveness and Tolerability of Perampanel in Children and Adolescents with Refractory Epilepsies: First Experiences

(2015) Ulrich Stephani et al.   NEUROPEDIATRICS

The rise and fall of felbamate as a treatment for partial epilepsy – aplastic anemia and hepatic failure to blame?

(2015) Karan Thakkar et al.   Expert Review of Neurotherapeutics

The ketogenic diet in pharmacoresistant childhood epilepsy

(2015) Steven Parrish Winesett et al.   Expert Review of Neurotherapeutics

Perampanel in the treatment of focal and idiopathic generalized epilepsies and of status epilepticus

(2015) Adam Strzelczyk et al.   Expert Review of Clinical Pharmacology

Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years

(2014) Joan A. Conry et al.   EPILEPSIA

First clinical experiences with perampanel-The Kork experience in 74 patients

(2014) Bernhard J. Steinhoff et al.   EPILEPSIA

Rufinamide as an adjunctive therapy for Lennox–Gastaut syndrome: A randomized double-blind placebo-controlled trial in Japan

(2014) Yoko Ohtsuka et al.   EPILEPSY RESEARCH

Efficacy and safety of felbamate in children with refractory epilepsy

(2014) Eli Heyman et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Use of the Modified Atkins Diet in Lennox Gastaut Syndrome

(2014) Suvasini Sharma et al.   JOURNAL OF CHILD NEUROLOGY

The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model

(2014) Mussie Ghezu Hadera et al.   JOURNAL OF NEUROCHEMISTRY

Efficacy and Tolerability of Methylprednisolone Pulse Therapy in Childhood Epilepsies Other Than Infantile Spasms

(2014) Friedrich Ebinger et al.   NEUROPEDIATRICS

Adjunctive Levetiracetam Treatment in Pediatric Lennox-Gastaut Syndrome

(2014) Hyo Jeong Kim et al.   PEDIATRIC NEUROLOGY

Ketogenic diet in patients with Lennox–Gastaut syndrome

(2014) Roberto Horacio Caraballo et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Experience in the use of clobazam in the treatment of Lennox–Gastaut syndrome

(2014) Gabriela Purcarin et al.   Therapeutic Advances in Neurological Disorders

Long-term outcome after callosotomy or vagus nerve stimulation in consecutive prospective cohorts of children with Lennox–Gastaut or Lennox-like syndrome and non-specific MRI findings

(2013) Arthur Cukiert et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Effectiveness and tolerability of rufinamide in children and young adults with Lennox–Gastaut syndrome: A single center study in Korea

(2012) Eun Hye Lee et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Efficacy of the ketogenic diet in Lennox-Gastaut syndrome: a retrospective review of one institution’s experience and summary of the literature

(2012) MONICA E LEMMON et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome

(2012) Shin Hye Kim et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox–Gastaut syndrome: A meta-analysis

(2012) Guido Lancman et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Definition and natural history of Lennox-Gastaut syndrome

(2011) Peter R. Camfield   EPILEPSIA

Strategies for transitioning to adult care for youth with Lennox-Gastaut syndrome and related disorders

(2011) Peter R. Camfield et al.   EPILEPSIA

The NMDA receptor complex as a therapeutic target in epilepsy: a review

(2011) Mehdi Ghasemi et al.   EPILEPSY & BEHAVIOR

Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome

(2011) Y. T. Ng et al.   NEUROLOGY

Combining antiepileptic drugs—Rational polytherapy?

(2011) Martin J. Brodie et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Treatment of Lennox-Gastaut syndrome: overview and recent findings

(2011) Kenou Rijckevorsel   Neuropsychiatric Disease and Treatment

Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study

(2010) G. Kluger et al.   ACTA NEUROLOGICA SCANDINAVICA

Quality of life in rare genetic conditions: A systematic review of the literature

(2010) Julie S. Cohen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Medical Management of Lennox-Gastaut Syndrome

(2010) Aspasia Michoulas et al.   CNS DRUGS

First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy

(2010) Gerhard Kluger et al.   EPILEPSY & BEHAVIOR

Efficacy of Felbamate in the Treatment of Intractable Pediatric Epilepsy

(2010) Mary L. Zupanc et al.   PEDIATRIC NEUROLOGY

Rufinamide in children and adults with Lennox–Gastaut syndrome: First Italian multicenter experience

(2010) Giangennaro Coppola et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Rufinamide: A Novel Broad-Spectrum Antiepileptic Drug

(2010) James W. Wheless et al.   Epilepsy Currents

Treatment of Lennox-Gastaut Syndrome (LGS)

(2009) Colin D. Ferrie et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Increased Risk of Death Among Children With Lennox-Gastaut Syndrome and Infantile Spasms

(2009) Andrew R. Autry et al.   JOURNAL OF CHILD NEUROLOGY

Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: Literature review

(2009) Katy Gallop et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Lennox-Gastaut Syndrome (LGS): Development of conceptual models of health-related quality of life (HRQL) for caregivers and children

(2009) Katy Gallop et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Clobazam in the treatment of Lennox-Gastaut syndrome

(2008) Joan A. Conry et al.   EPILEPSIA

Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology

(2008) Alexis Arzimanoglou et al.   LANCET NEUROLOGY

Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome

(2008) T. Glauser et al.   NEUROLOGY

Cost of Epilepsy

(2008) Adam Strzelczyk et al.   PHARMACOECONOMICS

The impact of side effects on long-term retention in three new antiepileptic drugs

(2008) Hans P. Bootsma et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Clinical efficacy of zonisamide in Lennox–Gastaut syndrome: Korean multicentric experience

(2007) Su Jeong You et al.   BRAIN & DEVELOPMENT