Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma

(2018) Francesca Ferrucci et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

(2018) Rhamy Zeid et al.   NATURE GENETICS

Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

(2018) Presha Rajbhandari et al.   Cancer Discovery

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells

(2017) Tomoya Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway

(2017) Bin Zhu et al.   ONCOLOGY REPORTS

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

(2017) Mark W. Zimmerman et al.   Cancer Discovery

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

Antitumor activity of an anti-CD98 antibody

(2015) Gregory M. Hayes et al.   INTERNATIONAL JOURNAL OF CANCER

Advances in Risk Classification and Treatment Strategies for Neuroblastoma

(2015) Navin R. Pinto et al.   JOURNAL OF CLINICAL ONCOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

(2015) Daniel R. Carter et al.   Science Translational Medicine

CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction

(2014) S. Estrach et al.   CANCER RESEARCH

CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma

(2014) Miroru Toyoda et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The function of spermine

(2014) Anthony E. Pegg   IUBMB LIFE

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential

(2014) Himisha Beltran   MOLECULAR CANCER RESEARCH

Identification of a mammalian vesicular polyamine transporter

(2014) Miki Hiasa et al.   Scientific Reports

Polyamines and membrane transporters

(2013) Ahmed A. Abdulhussein et al.   AMINO ACIDS

RCircos: an R package for Circos 2D track plots

(2013) Hongen Zhang et al.   BMC BIOINFORMATICS

AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

(2013) Katherine Samal et al.   INTERNATIONAL JOURNAL OF CANCER

Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3

(2013) Monica Sala-Rabanal et al.   MOLECULAR PHARMACEUTICS

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

(2013) H Kocak et al.   Cell Death & Disease

Neuroblastoma and MYCN

(2013) M. Huang et al.   Cold Spring Harbor Perspectives in Medicine

A Phase III Skin Cancer Chemoprevention Study of DFMO: Long-term Follow-up of Skin Cancer Events and Toxicity

(2012) S. M. Kreul et al.   Cancer Prevention Research

CD98 at the crossroads of adaptive immunity and cancer

(2012) J. M. Cantor et al.   JOURNAL OF CELL SCIENCE

Discovery of SLC3A2 Cell Membrane Protein as a Potential Gastric Cancer Biomarker: Implications in Molecular Imaging

(2012) Yixuan Yang et al.   JOURNAL OF PROTEOME RESEARCH

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

(2012) L. J. Valentijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

(2011) Michelle J. Henderson et al.   JNCI-Journal of the National Cancer Institute

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract

(2010) Takeshi Uemura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at theTRKAandp75NTRPromoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

(2010) Nunzio Iraci et al.   CANCER RESEARCH

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

(2010) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

OCT2 and MATE1 Provide Bidirectional Agmatine Transport

(2010) Tate N. Winter et al.   MOLECULAR PHARMACEUTICS

The Importance of Identifying and Validating Prognostic Factors in Oncology

(2010) Susan Halabi et al.   SEMINARS IN ONCOLOGY

The polyamine metabolism genesornithine decarboxylaseandantizyme 2predict aggressive behavior in neuroblastomas with and withoutMYCNamplification

(2009) Dirk Geerts et al.   INTERNATIONAL JOURNAL OF CANCER

The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5

(2009) Mustapha Aouida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular characterization of a human cation-Cl−cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport

(2009) Nikolas D. Daigle et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipophilic Lysine−Spermine Conjugates Are Potent Polyamine Transport Inhibitors for Use in Combination with a Polyamine Biosynthesis Inhibitor

(2009) Mark R. Burns et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

(2008) A. R. Simoneau et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

(2008) M. D. Hogarty et al.   CANCER RESEARCH

Identification and Characterization of a Diamine Exporter in Colon Epithelial Cells

(2008) Takeshi Uemura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY