GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Amino acid sensing and activation of mechanistic target of rapamycin complex 1

(2016) Daniel J. Ham et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

eIF4A inactivates TORC1 in response to amino acid starvation

(2016) Foivos‐Filippos Tsokanos et al.   EMBO JOURNAL

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

(2014) Janice D. Thomas et al.   CANCER CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

(2014) Julien Averous et al.   CELLULAR SIGNALLING

Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAiTernary Complex and eIF3 Stabilize the 43 S Preinitiation Complex

(2014) Masaaki Sokabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

(2013) Michael D. Dennis et al.   CELLULAR SIGNALLING

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals

(2009) C. Chaveroux et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE