Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases

Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis

(2020) Grace L. Wong et al.   Cancers

Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

(2020) Yabin Yu et al.   Cancer Cell International

MiR-1246 Promotes Metastasis and Invasion of A549 cells by Targeting GSK-3β‒Mediated Wnt/β-Catenin Pathway

(2019) Fan Yang et al.   Cancer Research and Treatment

Regulation of miRNAs by Snail during epithelial-to-mesenchymal transition in HT29 colon cancer cells

(2019) Patrycja Przygodzka et al.   Scientific Reports

Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer

(2019) M.C. Casey et al.   BMC CANCER

Exosomal miR‐1246 derived from human umbilical cord blood mesenchymal stem cells attenuates hepatic ischemia reperfusion injury by modulating T helper 17/regulatory T balance

(2019) Kun Xie et al.   IUBMB LIFE

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

(2019) Sherona R. Sirkisoon et al.   ONCOGENE

Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4

(2018) Li-Jun Mo et al.   BRITISH JOURNAL OF CANCER

Overexpression of miR-1290 contributes to cell proliferation and invasion of non small cell lung cancer by targeting interferon regulatory factor 2

(2018) Jian-jun Jin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer

(2018) Sherona R. Sirkisoon et al.   ONCOGENE

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons

(2018) Kangmu Ma et al.   Translational Neurodegeneration

MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2

(2017) Cong Li et al.   ONCOLOGY REPORTS

MiR-1290 Contributes to Colorectal Cancer Cell Proliferation by Targeting INPP4B

(2017) Qingzhu Ma et al.   ONCOLOGY RESEARCH

miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A

(2017) Alexander Bott et al.   Oncotarget

Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal cells

(2017) Ágota Tűzesi et al.   Oncotarget

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer

(2016) Christina Vorvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

(2016) F. Xing et al.   CANCER RESEARCH

Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells

(2016) Stella Chai et al.   HEPATOLOGY

Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression

(2016) Wen Cai Zhang et al.   Nature Communications

Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma

(2016) Sujata Sakha et al.   Scientific Reports

FOXA2 mRNA expression is associated with relapse in patients with Triple-Negative/Basal-like breast carcinoma

(2015) Ariadna Perez-Balaguer et al.   BREAST CANCER RESEARCH AND TREATMENT

Ciliary neurotrophic factor protects SH-SY5Y neuroblastoma cells against Aβ 1-42 -induced neurotoxicity via activating the JAK2/STAT3 axis

(2015) Ke Wang et al.   FOLIA NEUROPATHOLOGICA

MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction

(2015) SAI WANG et al.   Molecular Medicine Reports

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis

(2015) Ming Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer

(2015) Yumi Endo et al.   BMC CANCER

FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition

(2014) Jian Wang et al.   CARCINOGENESIS

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth

(2013) Hu Zhu et al.   CANCER LETTERS

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc modulates microRNA processing via the transcriptional regulation of Drosha

(2013) Xingwu Wang et al.   Scientific Reports

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

(2012) E. Metzakopian et al.   DEVELOPMENT

miR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer

(2012) Yumi Endo et al.   ENDOCRINE-RELATED CANCER

p53 downregulates Down syndrome-associated DYRK1A through miR-1246

(2011) Yu Zhang et al.   EMBO REPORTS

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells

(2011) X Cao et al.   ONCOGENE

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

(2010) Yunneng Tang et al.   CELL RESEARCH

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

(2010) Lucy Pigati et al.   PLoS One

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells

(2008) Brian D. Adams et al.   ENDOCRINOLOGY

Chromatin structure analyses identify miRNA promoters

(2008) F. Ozsolak et al.   GENES & DEVELOPMENT