The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3

(2015) D. Madera et al.   Cancer Prevention Research

Antihypertensive mechanisms of intra-renal dopamine

(2015) Ming-Zhi Zhang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

(2015) R. Planells-Cases et al.   EMBO JOURNAL

Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds

(2015) Venkata V.V.R. Marada et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Immunohistochemical localization of OCT2 in the cochlea of various species

(2015) Victoria Hellberg et al.   LARYNGOSCOPE

Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity

(2015) Claudia Lanvers-Kaminsky et al.   PHARMACOGENOMICS

Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cells

(2015) C Arimany-Nardi et al.   PHARMACOGENOMICS JOURNAL

Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs

(2015) Venkata V.V.R. Marada et al.   PHARMACOLOGICAL RESEARCH

Management of dose variability and side effects for individualized cancer pharmacotherapy with tyrosine kinase inhibitors

(2015) Tomohiro Terada et al.   PHARMACOLOGY & THERAPEUTICS

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

(2015) Navjotsingh Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What is the future of targeted therapy in rheumatology: biologics or small molecules?

(2014) Attila Mócsai et al.   BMC Medicine

Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

(2014) A. J. M. Nieuweboer et al.   CANCER RESEARCH

Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53

(2014) J. A. Sprowl et al.   CLINICAL CANCER RESEARCH

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

(2014) Ligong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

(2013) A. T. Nies et al.   CLINICAL CANCER RESEARCH

Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

(2013) E. I. Zimmerman et al.   CLINICAL CANCER RESEARCH

Characteristics of Pemetrexed Transport by Renal Basolateral Organic Anion Transporter hOAT3

(2013) Tomohiko Kurata et al.   Drug Metabolism and Pharmacokinetics

Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity

(2013) S. S. More et al.   JOURNAL OF NEUROSCIENCE

Precise comparison of protein localization among OCT, OAT, and MATE in human kidney

(2013) Hideyuki Motohashi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins

(2013) Koji Kato et al.   PHARMACEUTICAL RESEARCH

Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2

(2013) J. A. Sprowl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs)

(2013) Qing Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events

(2012) Kazufumi Iwata et al.   Clinical and Experimental Nephrology

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

(2012) G. Ciarimboli et al.   CLINICAL CANCER RESEARCH

Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel

(2012) A.-J. M. de Graan et al.   CLINICAL CANCER RESEARCH

Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients

(2012) Jing Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

(2012) Matthias B. Wittwer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system

(2012) Lorena Pochini et al.   LIFE SCIENCES

Inhibition of OCTN2-Mediated Transport of Carnitine by Etoposide

(2012) C. Hu et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic Rat Models

(2012) Mohamed M. Sayed-Ahmed et al.   Oxidative Medicine and Cellular Longevity

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3

(2012) L Chen et al.   PHARMACOGENOMICS JOURNAL

Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action

(2012) Hao-Jie Zhu et al.   PHARMACOLOGICAL RESEARCH

Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis

(2012) Christian Schmidt-Lauber et al.   PLoS One

Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport

(2011) Martin Svoboda et al.   BIOMEDICINE & PHARMACOTHERAPY

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment

(2011) A. Grabner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of organic cation transporters in drug-induced toxicity

(2011) Giuliano Ciarimboli   Expert Opinion on Drug Metabolism & Toxicology

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

(2011) Toshinori Komatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons

(2011) N. N. Jong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

(2011) T. Minematsu et al.   MOLECULAR CANCER THERAPEUTICS

Properties and regulation of organic cation transport in freshly isolated mouse proximal tubules analyzed with a fluorescence reader-based method

(2011) Svenja K. Holle et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pharmacogenetic analyses of cisplatin-induced nephrotoxicity indicate a renoprotective effect ofERCC1polymorphisms

(2011) Mladen V Tzvetkov et al.   PHARMACOGENOMICS

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

(2011) Anne T. Nies et al.   PLoS One

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines

(2010) Maricla Galetti et al.   BIOCHEMICAL PHARMACOLOGY

The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34+ cells

(2010) J. R. Engler et al.   BLOOD

Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)

(2010) H Burger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting

(2010) C. S. Lancaster et al.   CLINICAL CANCER RESEARCH

Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular Accumulation

(2010) M. A. Elmeliegy et al.   CLINICAL CANCER RESEARCH

OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects

(2010) J. M. Moreno-Navarrete et al.   DIABETES

Castration-Dependent Pharmacokinetics of Docetaxel in Patients With Prostate Cancer

(2010) Ryan M. Franke et al.   JOURNAL OF CLINICAL ONCOLOGY

Nilotinib does not significantly reduce imatinib OCT-1 activity in either cell lines or primary CML cells

(2010) L Eadie et al.   LEUKEMIA

Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue

(2010) Swati S. More et al.   MOLECULAR CANCER THERAPEUTICS

New Clues for Nephrotoxicity Induced by Ifosfamide: Preferential Renal Uptake via the Human Organic Cation Transporter 2

(2010) Giuliano Ciarimboli et al.   MOLECULAR PHARMACEUTICS

Neuronal expression of copper transporter 1 in rat dorsal root ganglia: association with platinum neurotoxicity

(2009) Johnson J. Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Expression of Human Organic Cation Transporter 3 in Kidney Carcinoma Cell Lines Increases Chemosensitivity to Melphalan, Irinotecan, and Vincristine

(2009) Volodymyr Shnitsar et al.   CANCER RESEARCH

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Vegetarian Diet Affects Genes of Oxidative Metabolism and Collagen Synthesis

(2008) Heidrun Karlic et al.   ANNALS OF NUTRITION AND METABOLISM

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia

(2008) A. Giannoudis et al.   BLOOD

Interaction of Imatinib with Human Organic Ion Carriers

(2008) S. Hu et al.   CLINICAL CANCER RESEARCH

Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition

(2008) T. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

(2008) V. Hellberg et al.   JNCI-Journal of the National Cancer Institute

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

(2008) M. Okabe et al.   MOLECULAR CANCER THERAPEUTICS

The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs

(2008) C. A. Larson et al.   MOLECULAR PHARMACOLOGY

Organic cation transporters

(2008) G. Ciarimboli   XENOBIOTICA

Functional relevance of carnitine transporter OCTN2 to brain distribution of l-carnitine and acetyl-l-carnitine across the blood-brain barrier

(2003) Yasuto Kido et al.   JOURNAL OF NEUROCHEMISTRY