An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates
Authors
Keywords
-
Journal
BIOMATERIALS
Volume 286, Issue -, Pages 121570
Publisher
Elsevier BV
Online
2022-05-07
DOI
10.1016/j.biomaterials.2022.121570
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Self-assembled mRNA vaccines
- (2021) Jeonghwan Kim et al. ADVANCED DRUG DELIVERY REVIEWS
- Encapsulation state of messenger RNA inside lipid nanoparticles
- (2021) Mark L. Brader et al. BIOPHYSICAL JOURNAL
- mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
- (2021) Linde Schoenmaker et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
- (2021) Kimberly J. Hassett et al. JOURNAL OF CONTROLLED RELEASE
- The dawn of mRNA vaccines: The COVID-19 case
- (2021) Rein Verbeke et al. JOURNAL OF CONTROLLED RELEASE
- Lipid-nanoparticle encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
- (2021) Cory J. Knudson et al. MOLECULAR THERAPY
- Microfluidic formulation of nanoparticles for biomedical applications
- (2021) Sarah J. Shepherd et al. BIOMATERIALS
- Theoretical basis for stabilizing messenger RNA through secondary structure design
- (2021) Hannah K Wayment-Steele et al. NUCLEIC ACIDS RESEARCH
- Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
- (2021) Manuel J. Carrasco et al. Communications Biology
- Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA
- (2021) Mark Cornebise et al. ADVANCED FUNCTIONAL MATERIALS
- Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine
- (2021) Makda S. Gebre et al. NATURE
- A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
- (2021) Meredith Packer et al. Nature Communications
- The promise of mRNA vaccines: a biotech and industrial perspective
- (2020) Nicholas A. C. Jackson et al. npj Vaccines
- How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms
- (2020) Meredith Corley et al. MOLECULAR CELL
- Lipid nanoparticles for nucleic acid delivery: Current perspectives
- (2020) Eleni Samaridou et al. ADVANCED DRUG DELIVERY REVIEWS
- Recent advances in mRNA vaccine technology
- (2020) Norbert Pardi et al. CURRENT OPINION IN IMMUNOLOGY
- SARS-CoV-2 vaccines in development
- (2020) Florian Krammer NATURE
- Addressing the Cold Reality of mRNA Vaccine Stability
- (2020) Daan J.A. Crommelin et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
- (2019) Khalid A. Hajj et al. Small
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo
- (2019) Yusuke Sato et al. JOURNAL OF CONTROLLED RELEASE
- Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
- (2019) Kimberly J. Hassett et al. Molecular Therapy-Nucleic Acids
- Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery
- (2019) Melissa P. Lokugamage et al. ADVANCED MATERIALS
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
- (2017) S Guan et al. GENE THERAPY
- Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
- (2017) Frank Liang et al. MOLECULAR THERAPY
- Lipid Nanoparticle Systems for Enabling Gene Therapies
- (2017) Pieter R. Cullis et al. MOLECULAR THERAPY
- N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
- (2017) Yuri V. Svitkin et al. NUCLEIC ACIDS RESEARCH
- Advances in the delivery of RNA therapeutics: from concept to clinical reality
- (2017) James C. Kaczmarek et al. Genome Medicine
- Tools for translation: non-viral materials for therapeutic mRNA delivery
- (2017) Khalid A. Hajj et al. Nature Reviews Materials
- Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
- (2017) Johannes Lutz et al. npj Vaccines
- pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery
- (2016) Manon Ripoll et al. ACS Applied Materials & Interfaces
- Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
- (2016) Owen S. Fenton et al. ADVANCED MATERIALS
- A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
- (2016) Anita Jarzębińska et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
- (2016) Bin Li et al. Scientific Reports
- siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo
- (2015) Y. Suzuki et al. JOURNAL OF CONTROLLED RELEASE
- Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
- (2015) Alex K. K. Leung et al. JOURNAL OF PHYSICAL CHEMISTRY B
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Challenges and advances towards the rational design of mRNA vaccines
- (2013) Charlotte Pollard et al. TRENDS IN MOLECULAR MEDICINE
- Advances in Lipid Nanoparticles for siRNA Delivery
- (2013) Yuen Tam et al. Pharmaceutics
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
- (2012) Yusuke Sato et al. JOURNAL OF CONTROLLED RELEASE
- Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing
- (2012) Igor V. Zhigaltsev et al. LANGMUIR
- Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin
- (2012) Katalin Karikó et al. MOLECULAR THERAPY
- Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
- (2012) Nathan M Belliveau et al. Molecular Therapy-Nucleic Acids
- Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
- (2011) Michael S D Kormann et al. NATURE BIOTECHNOLOGY
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L
- (2011) B. R. Anderson et al. NUCLEIC ACIDS RESEARCH
- Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines
- (2011) Myrra G. Carstens et al. VACCINE
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
- (2009) Patrick Midoux et al. BRITISH JOURNAL OF PHARMACOLOGY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search