Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

Development of Droplet Digital PCR-Based Assays to Quantify HIV Proviral and Integrated DNA in Brain Tissues from Viremic Individuals with Encephalitis and Virally Suppressed Aviremic Individuals

(2022) Hye Kyung Chung et al.   Microbiology Spectrum

HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)

(2021) Natalie N. Kinloch et al.   Nature Communications

HIV persists throughout deep tissues with repopulation from multiple anatomical sources

(2020) Antoine Chaillon et al.   JOURNAL OF CLINICAL INVESTIGATION

Defective HIV-1 proviruses produce viral proteins

(2020) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS

(2020) Cheri A. Lee et al.   mBio

Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy

(2020) Emmanouil Papasavvas et al.   CLINICAL INFECTIOUS DISEASES

HIV infects astrocytes in vivo and egresses from the brain to the periphery

(2020) Victoria Lutgen et al.   PLoS Pathogens

Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

(2020) Rajesh T Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Similar frequency and inducibility of intact HIV-1 proviruses in blood and lymph nodes

(2020) Alyssa R Martin et al.   JOURNAL OF INFECTIOUS DISEASES

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance

(2019) Serena Spudich et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1–Infected Adults in the United States

(2018) Shibani S Mukerji et al.   CLINICAL INFECTIOUS DISEASES

Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?

(2018) Peter D Burbelo et al.   JOURNAL OF INFECTIOUS DISEASES

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques

(2018) Denise C. Hsu et al.   JOURNAL OF VIROLOGY

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

Blood–brain barrier pericytes as a target for HIV-1 infection

(2018) Luc Bertrand et al.   BRAIN

HIV-1 RNA Detected in the CNS after Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells

(2018) Sarah B Joseph et al.   CLINICAL INFECTIOUS DISEASES

Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy

(2017) Stefanie Perez et al.   JOURNAL OF NEUROVIROLOGY

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

HIV-Tat regulates macrophage gene expression in the context of neuroAIDS

(2017) Loreto Carvallo et al.   PLoS One

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

Asymptomatic Cerebrospinal Fluid HIV-1 Viral Blips and Viral Escape During Antiretroviral Therapy: A Longitudinal Study

(2016) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence and Correlates of Persistent HIV-1 RNA in Cerebrospinal Fluid During Antiretroviral Therapy

(2016) Albert M. Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation

(2014) Viktor Dahl et al.   AIDS

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy

(2011) Tae-Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression

(2011) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells

(2009) Nicoletta Casartelli et al.   JOURNAL OF EXPERIMENTAL MEDICINE