Annual Research Review: Discovery science strategies in studies of the pathophysiology of child and adolescent psychiatric disorders - promises and limitations

Role of epigenetic factors in the development of mental illness throughout life

(2016) Jerry Guintivano et al.   NEUROSCIENCE RESEARCH

An association between a dopamine transporter gene (SLC6A3) haplotype and ADHD symptom measures in nonclinical adults

(2015) Janette H.S. Tong et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies

(2015) Javier Arnedo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genetic markers of white matter integrity in schizophrenia revealed by parallel ICA

(2015) Cota Navin Gupta et al.   Frontiers in Human Neuroscience

Commentary: We've only just begun: unravelling the underlying genetics of neurodevelopmental disorders - a commentary on Kiser et al. (2015)

(2015) David Coghill   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Annual Research Review: The (epi)genetics of neurodevelopmental disorders in the era of whole-genome sequencing - unveiling the dark matter

(2015) Dominik P. Kiser et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

The molecular genetic architecture of attention deficit hyperactivity disorder

(2015) Z Hawi et al.   MOLECULAR PSYCHIATRY

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

Loss of δ-catenin function in severe autism

(2015) Tychele N. Turner et al.   NATURE

Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder

(2015) W. Brad Ruzicka et al.   JAMA Psychiatry

Connectomics and new approaches for analyzing human brain functional connectivity

(2015) R Cameron Craddock et al.   GigaScience

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics

(2014) David C. Glahn et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Endogeneity in high dimensions

(2014) Jianqing Fan et al.   ANNALS OF STATISTICS

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Practitioner Review: A critical perspective on gene-environment interaction models - what impact should they have on clinical perceptions and practice?

(2014) Marcus R. Munafò et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Editorial: Acknowledging complexity and heterogeneity in causality - implications of recent insights into neuropsychology of childhood disorders for clinical practice

(2014) David Coghill   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Schizophrenia genetics: emerging themes for a complex disorder

(2014) D H Kavanagh et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Genesis of a complex disease

(2014) Jonathan Flint et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Making big data open: data sharing in neuroimaging

(2014) Russell A Poldrack et al.   NATURE NEUROSCIENCE

Decoding neuroproteomics: integrating the genome, translatome and functional anatomy

(2014) Robert R Kitchen et al.   NATURE NEUROSCIENCE

Putting big data to good use in neuroscience

(2014) Terrence J Sejnowski et al.   NATURE NEUROSCIENCE

Dimensionality reduction for large-scale neural recordings

(2014) John P Cunningham et al.   NATURE NEUROSCIENCE

Genotype to phenotype relationships in autism spectrum disorders

(2014) Jonathan Chang et al.   NATURE NEUROSCIENCE

Big data from small data: data-sharing in the 'long tail' of neuroscience

(2014) Adam R Ferguson et al.   NATURE NEUROSCIENCE

Whole-genome analyses of whole-brain data: working within an expanded search space

(2014) Sarah E Medland et al.   NATURE NEUROSCIENCE

The big data challenges of connectomics

(2014) Jeff W Lichtman et al.   NATURE NEUROSCIENCE

Disentangling the heterogeneity of autism spectrum disorder through genetic findings

(2014) Shafali S. Jeste et al.   Nature Reviews Neurology

The Big Data Problem: Turning Maps into Knowledge

(2014) Florian Engert   NEURON

Great Expectations: Using Whole-Brain Computational Connectomics for Understanding Neuropsychiatric Disorders

(2014) Gustavo Deco et al.   NEURON

The DNA Methylome and Transcriptome of Different Brain Regions in Schizophrenia and Bipolar Disorder

(2014) Yun Xiao et al.   PLoS One

Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia

(2014) S. A. Meda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic architecture of psychophysiological phenotypes

(2014) Marcus R. Munafò et al.   PSYCHOPHYSIOLOGY

Clustering by fast search and find of density peaks

(2014) A. Rodriguez et al.   SCIENCE

Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease

(2014) Jonathan Flint et al.   TRENDS IN NEUROSCIENCES

Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology

(2014) Russell G. Port et al.   Frontiers in Cellular Neuroscience

Genetics of Schizophrenia

(2014) Irene Escudero et al.   Current Psychiatry Reports

Methylome-Wide Association Study of Schizophrenia

(2014) Karolina A. Aberg et al.   JAMA Psychiatry

Challenges of Big Data analysis

(2014) Jianqing Fan et al.   National Science Review

DNA methylation changes in the postmortem dorsolateral prefrontal cortex of patients with schizophrenia

(2014) Shusuke Numata et al.   Frontiers in Genetics

Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms

(2014) Sylvie Tordjman et al.   Frontiers in Psychiatry

Network Analysis: An Integrative Approach to the Structure of Psychopathology

(2013) Denny Borsboom et al.   Annual Review of Clinical Psychology

Integrative Data Analysis in Clinical Psychology Research

(2013) Andrea M. Hussong et al.   Annual Review of Clinical Psychology

Endophenotypes in Psychopathology Research: Where Do We Stand?

(2013) Gregory A. Miller et al.   Annual Review of Clinical Psychology

Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study

(2013) Sabin Khadka et al.   BIOLOGICAL PSYCHIATRY

Advancing biomarker research: utilizing ‘Big Data’ approaches for the characterization and prevention of bipolar disorder

(2013) Roger S McIntyre et al.   BIPOLAR DISORDERS

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

(2013) Bruce N Cuthbert et al.   BMC Medicine

Cluster analysis of cognitive deficits may mark heterogeneity in schizophrenia in terms of outcome and response to treatment

(2013) Elsa Gilbert et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

Genetically meaningful phenotypic subgroups in autism spectrum disorders

(2013) O. J. Veatch et al.   GENES BRAIN AND BEHAVIOR

Different neurodevelopmental symptoms have a common genetic etiology

(2013) Erik Pettersson et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Shared genetics among major psychiatric disorders

(2013) Alessandro Serretti et al.   LANCET

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence

(2013) Andres Moreno-De-Luca et al.   LANCET NEUROLOGY

The NIMH Research Domain Criteria (RDoC) Project: implications for genetics research

(2013) Janine M. Simmons et al.   MAMMALIAN GENOME

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

(2013) P A Thomson et al.   MOLECULAR PSYCHIATRY

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

(2013) Karen A. Hunt et al.   NATURE

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

DSM-5 and RDoC: progress in psychiatry research?

(2013) B. J. Casey et al.   NATURE REVIEWS NEUROSCIENCE

Non-negative matrix factorization of multimodal MRI, fMRI and phenotypic data reveals differential changes in default mode subnetworks in ADHD

(2013) Ariana Anderson et al.   NEUROIMAGE

Epigenetic dynamics in psychiatric disorders: Environmental programming of neurodevelopmental processes

(2013) Daniel Kofink et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Measuring cell-type specific differential methylation in human brain tissue

(2013) Carolina M Montaño et al.   GENOME BIOLOGY

Common variants at 12q15 and 12q24 are associated with infant head circumference

(2012) H Rob Taal et al.   NATURE GENETICS

Common variants at 6q22 and 17q21 are associated with intracranial volume

(2012) et al.   NATURE GENETICS

Common variants at 12q14 and 12q24 are associated with hippocampal volume

(2012) et al.   NATURE GENETICS

Identification of common variants associated with human hippocampal and intracranial volumes

(2012) Jason L Stein et al.   NATURE GENETICS

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

(2012) Sarah R Gilman et al.   NATURE NEUROSCIENCE

Open Neuroscience Solutions for the Connectome-wide Association Era

(2012) Michael Peter Milham   NEURON

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

Data sharing in neuroimaging research

(2012) Jean-Baptiste Poline et al.   Frontiers in Neuroinformatics

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

After GWAS: Searching for Genetic Risk for Schizophrenia and Bipolar Disorder

(2011) Elliot S. Gershon et al.   AMERICAN JOURNAL OF PSYCHIATRY

High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes

(2011) David C. Glahn et al.   BIOLOGICAL PSYCHIATRY

The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder

(2011) J Jogia et al.   MOLECULAR PSYCHIATRY

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

(2011) A. C. Lionel et al.   Science Translational Medicine

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Copy Number Variations in Schizophrenia: Critical Review and New Perspectives on Concepts of Genetics and Disease

(2010) Anne S. Bassett et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

(2010) Nanda N. J. Rommelse et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study

(2010) M. Ribasés et al.   GENES BRAIN AND BEHAVIOR

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

(2010) M Arcos-Burgos et al.   MOLECULAR PSYCHIATRY

The CACNA1C risk variant for bipolar disorder influences limbic activity

(2010) M Wessa et al.   MOLECULAR PSYCHIATRY

Default mode network abnormalities in bipolar disorder and schizophrenia

(2010) Dost Öngür et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Effects of a CACNA1C genotype on attention networks in healthy individuals

(2010) M. Thimm et al.   PSYCHOLOGICAL MEDICINE

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging

(2010) M. Johnstone et al.   SCHIZOPHRENIA BULLETIN

Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis

(2009) Ronglai Shen et al.   BIOINFORMATICS

An evaluation of statistical approaches to rare variant analysis in genetic association studies

(2009) Andrew P. Morris et al.   GENETIC EPIDEMIOLOGY

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Neuroscience in the era of functional genomics and systems biology

(2009) Daniel H. Geschwind et al.   NATURE

Autism genetics: strategies, challenges, and opportunities

(2008) Brian J. O'Roak et al.   Autism Research

Calcium Channel Regulation and Presynaptic Plasticity

(2008) William A. Catterall et al.   NEURON

Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?

(2008) Raymond C.K. Chan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS