Nephroprotective Effects of Metformin in Diabetic Nephropathy

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

(2016) Jianzhong Li et al.   Scientific Reports

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-� via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells

(2015) Meichu Cheng et al.   AMERICAN JOURNAL OF NEPHROLOGY

Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats

(2015) Jing-Yu Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

(2015) Jiamei Lu et al.   LIFE SCIENCES

Epigenetic regulation in the acute kidney injury to chronic kidney disease transition

(2015) Roxana Rodríguez-Romo et al.   NEPHROLOGY

Metformin Use Reduction in Mild to Moderate Renal Impairment

(2015) James H. Flory et al.   JAMA Internal Medicine

Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers

(2015) Anne-Emilie Declèves et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Autophagy activation reduces renal tubular injury induced by urinary proteins

(2014) Wei Jing Liu et al.   Autophagy

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

Autophagy in diabetic nephropathy

(2014) Yan Ding et al.   JOURNAL OF ENDOCRINOLOGY

Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy

(2014) Ying Xu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

(2014) Shinji Kume et al.   Biomed Research International

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial–mesenchymal transition in renal tubular cells

(2013) Wei-Qing Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Detecting and controlling diabetic nephropathy: What do we know?

(2013) G. Appel   CLEVELAND CLINIC JOURNAL OF MEDICINE

Role of Endoplasmic Reticulum Stress in Diabetic Neuropathy

(2013) N. E. Cameron   DIABETES

Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation

(2013) Bidya Dhar Sahu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

mTOR Signaling in Autophagy Regulation in the Kidney

(2013) Ken Inoki   SEMINARS IN NEPHROLOGY

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Regulation of hypoxia-inducible factor in kidney disease

(2012) Masaomi Nangaku et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Impact of the Hypoxia-Inducible Factor-1   (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy

(2012) H. F. Gu et al.   DIABETES CARE

Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2012) Junghyun Kim et al.   Experimental Diabetes Research

Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Renal Tubular Cell Injury by Suppressing Reactive Oxygen Species Generation via Reducing Receptor for AGEs (RAGE) Expression

(2012) Y. Ishibashi et al.   HORMONE AND METABOLIC RESEARCH

The role of ATM in response to metformin treatment and activation of AMPK

(2012) Sook Wah Yee et al.   NATURE GENETICS

Activation of AMP-Activated Protein Kinase Inhibits Albumin-Induced Endoplasmic Reticulum Stress and Apoptosis through Inhibition of Reactive Oxygen Species

(2012) Eun Kyoung Lee et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells

(2011) Jimmy R. Thériault et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression

(2011) Abdulqader A. Alhaider et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2011) Yumi Takiyama et al.   DIABETES

Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency

(2011) K. J. Lipska et al.   DIABETES CARE

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Epithelial-mesenchymal transition in renal fibrosis - evidence for and against

(2011) Maria Fragiadaki et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Tuberin/mTOR Pathway Promotes Apoptosis of Tubular Epithelial Cells in Diabetes

(2011) C. Velagapudi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

(2011) V. Takiar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft

(2011) Jun Liu et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Induction of Diabetes in Aged C57B6 Mice Results in Severe Nephropathy

(2010) Jin Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin induces suppression of NAD(P)H oxidase activity in podocytes

(2010) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis

(2010) Sílvia Cufí et al.   CELL CYCLE

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients

(2010) Arpita Chakraborty et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

(2010) Ana I. Morales et al.   KIDNEY INTERNATIONAL

Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells

(2010) Zhengchao Wang et al.   KIDNEY INTERNATIONAL

Advanced Glycation end Products, Oxidative Stress and Diabetic Nephropathy

(2010) Sho-ichi Yamagishi et al.   Oxidative Medicine and Cellular Longevity

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Influence of metformin on GLUT1 gene and protein expression in rat streptozotocindiabetes mellitusmodel

(2010) Jelizaveta Sokolovska et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Diabetes mellitus: new challenges and innovative therapies

(2010) Cristina M. Sena et al.   EPMA Journal

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

(2009) W. Lieberthal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Meta-analysis: Metformin Treatment in Persons at Risk for Diabetes Mellitus

(2008) Shelley R. Salpeter et al.   AMERICAN JOURNAL OF MEDICINE

Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease

(2008) Guanghui Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin: Effects on Micro and Macrovascular Complications in Type 2 Diabetes

(2008) Clifford J. Bailey   CARDIOVASCULAR DRUGS AND THERAPY

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia: A nested case-control analysis

(2008) M. Bodmer et al.   DIABETES CARE

In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study

(2008) Hao Jun et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress

(2008) M. T. Lindenmeyer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA