Regulation of hypoxia-inducible factor in kidney disease

Aberrant Tubuloglomerular Feedback and HIF-1  Confer Resistance to Ischemia after Subtotal Nephrectomy

(2012) P. Singh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A

(2012) I. Mimura et al.   MOLECULAR AND CELLULAR BIOLOGY

The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration

(2012) Xiaofang Yu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transient Ureteral Obstruction Prevents against Kidney Ischemia/Reperfusion Injury via Hypoxia-Inducible Factor (HIF)-2α Activation

(2012) Shun Zhang et al.   PLoS One

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

(2012) Ruth E. Schietke et al.   PLoS One

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival

(2012) Elisa Conde et al.   PLoS One

Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI

(2011) Wen-Jie Yin et al.   EUROPEAN JOURNAL OF RADIOLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood oxygen level-dependent (BOLD) MRI of diabetic nephropathy: Preliminary experience

(2011) Zhen J. Wang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes

(2011) Imari Mimura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Hypoxia-Inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects against Ischemic Acute Kidney Injury

(2011) G. Schley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

(2011) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pre-treatment with isoflurane ameliorates renal ischemic–reperfusion injury in mice

(2011) Lei Zhang et al.   LIFE SCIENCES

Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase

(2011) Xiao-Li Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine

(2011) XIAOFANG YU et al.   NEPHROLOGY

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment

(2011) Z. Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells

(2010) Johannes Schödel et al.   KIDNEY INTERNATIONAL

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

(2010) Imari Mimura et al.   Nature Reviews Nephrology

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

(2010) Abigail Bigham et al.   PLoS Genetics

HIF-Prolyl Hydroxylases in the Rat Kidney

(2009) Johannes Schödel et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

(2009) Ruth Schietke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental ischemia–reperfusion: biases and myths—the proximal vs. distal hypoxic tubular injury debate revisited

(2009) Samuel N. Heyman et al.   KIDNEY INTERNATIONAL

Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy

(2009) Chung-Hsin Yeh et al.   LIFE SCIENCES

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

(2009) W. M. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbon Monoxide Ameliorates Renal Cold Ischemia-Reperfusion Injury With an Upregulation of Vascular Endothelial Growth Factor by Activation of Hypoxia-Inducible Factor

(2009) Gaetano Faleo et al.   TRANSPLANTATION

Repetitive Hypoxic Preconditioning Attenuates Renal Ischemia/Reperfusion Induced Oxidative Injury via Upregulating HIF-1α–Dependent bcl-2 Signaling

(2009) Chih-Ching Yang et al.   TRANSPLANTATION

Acute Kidney Injury in the Diabetic Rat: Studies in the Isolated Perfused and Intact Kidney

(2008) Christian Rosenberger et al.   AMERICAN JOURNAL OF NEPHROLOGY

Increased renal adrenomedullin expression in rats with ureteral obstruction

(2008) Rikke Nørregaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIF Activation Protects From Acute Kidney Injury

(2008) A. Weidemann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

(2008) C. Rosenberger et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Acute Inactivation of the VHL Gene Contributes to Protective Effects of Ischemic Preconditioning in the Mouse Kidney

(2008) Mitsuko Iguchi et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL