APPL1 gates long-term potentiation through its plekstrin homology domain

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

(2015) Inna Kalaidzidis et al.   JOURNAL OF CELL BIOLOGY

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression

(2014) K. L. Arendt et al.   JOURNAL OF CELL SCIENCE

Activity-dependent PI(3,5)P2synthesis controls AMPA receptor trafficking during synaptic depression

(2014) Amber J. McCartney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

(2014) Il Hwan Kim et al.   eLife

Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway

(2013) Z. Gan et al.   JOURNAL OF CELL SCIENCE

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Adaptor Protein APPL1 Couples Synaptic NMDA Receptor with Neuronal Prosurvival Phosphatidylinositol 3-Kinase/Akt Pathway

(2012) Y.-b. Wang et al.   JOURNAL OF NEUROSCIENCE

Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration

(2011) Margaret Sperow et al.   JOURNAL OF PHYSIOLOGY-LONDON

An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons

(2011) Devi Majumdar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

(2011) Hideji Murakoshi et al.   NATURE

PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility

(2011) Jae-Ick Kim et al.   NATURE NEUROSCIENCE

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

(2010) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

(2010) Sandra Jurado et al.   EMBO JOURNAL

Gamma-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons

(2010) Mónica Fernández-Monreal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Appl1Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts

(2009) Yinfei Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane

(2009) Kristin L Arendt et al.   NATURE NEUROSCIENCE

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Forskolin induction of late-LTP and up-regulation of 5 TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

(2008) Delphine Gobert et al.   JOURNAL OF NEUROCHEMISTRY

Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

(2008) Diego E Berman et al.   NATURE NEUROSCIENCE

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

(2008) S. V. Voronov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

(2008) C. D. Harvey et al.   SCIENCE