Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT–PIX complexes

Converging evidence does not supportGIT1as an ADHD risk gene

(2015) Marieke Klein et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Methionine Adenosyltransferase 2B–GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells

(2015) Hui Peng et al.   AMERICAN JOURNAL OF PATHOLOGY

The GTPase Regulatory Proteins Pix and Git Control Tissue Growth via the Hippo Pathway

(2015) Lucas G. Dent et al.   CURRENT BIOLOGY

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Gene expression profile in breast cancer comprising predictive markers for metastatic risk

(2015) S. Sirirattanakul et al.   GENETICS AND MOLECULAR RESEARCH

Guanine Nucleotide Exchange Factor αPIX Leads to Activation of the Rac 1 GTPase/Glycogen Phosphorylase Pathway in Interleukin (IL)-2-stimulated T Cells

(2015) Francisco Llavero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets

(2015) Zoltan Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C

(2015) Jiefang Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair

(2015) Daoyuan Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse

(2015) Mónica S. Montesinos et al.   NEURON

miR-135aInhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly RepressingArhgef6Expression

(2015) Katayoun Hemmesi et al.   STEM CELLS

GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

(2015) Jeng-Shou Chang et al.   Oncotarget

GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice

(2015) Yu-E Hao et al.   FEBS Open Bio

A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development

(2015) Sung-Tae Hong et al.   Experimental Neurobiology

αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor

(2015) Fanny Kortüm et al.   PLoS One

c-Cbl regulates αPix-mediated cell migration and invasion

(2014) Min Woo Seong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arhgef7 promotes activation of the Hippo pathway core kinase Lats

(2014) Emad Heidary Arash et al.   EMBO JOURNAL

β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo

(2014) Tatiana Omelchenko et al.   GENES & DEVELOPMENT

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly

(2014) E. Wilson et al.   JOURNAL OF CELL SCIENCE

 -PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2

(2014) J. Eitel et al.   JOURNAL OF IMMUNOLOGY

The Role of Pak-Interacting Exchange Factor-  Phosphorylation at Serines 340 and 583 by PKC  in Dopamine Release

(2014) T. Shirafuji et al.   JOURNAL OF NEUROSCIENCE

Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

(2014) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

(2014) S-H Chan et al.   ONCOGENE

Identification of Two Tyrosine Residues Required for the Intramolecular Mechanism Implicated in GIT1 Activation

(2014) Antonio Totaro et al.   PLoS One

Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases

(2014) Diana Chang et al.   PLoS One

The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling

(2014) J. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cool-1-Mediated Inhibition of c-Cbl Modulates Multiple Critical Properties of Glioblastomas, Including the Ability to Generate Tumors In Vivo

(2014) Brett M. Stevens et al.   STEM CELLS

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

(2014) Ruth Chia et al.   Nature Communications

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling

(2014) Jasmin Podufall et al.   Cell Reports

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4

(2013) Karina Häbig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

(2013) W.-C. Huang et al.   CANCER RESEARCH

TNF-alpha and melphalan modulate a specific group of early expressed genes in a murine melanoma model

(2013) Vladmir Cláudio Cordeiro de Lima et al.   CYTOKINE

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer

(2013) Hui Peng et al.   HEPATOLOGY

Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1

(2013) W. Zhou et al.   JOURNAL OF CELL SCIENCE

PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth

(2013) M. Santiago-Medina et al.   JOURNAL OF CELL SCIENCE

GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling

(2013) M. Fiuza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons

(2012) Antonio Totaro et al.   BIOLOGY OF THE CELL

Association study ofGIT1gene with attention-deficit hyperactivity disorder in Brazilian children and adolescents

(2012) A. Salatino-Oliveira et al.   GENES BRAIN AND BEHAVIOR

Induction, modulation and potential targets of miR-210 in pancreatic cancer cells

(2012) Wei-Yun Chen et al.   Hepatobiliary & Pancreatic Diseases International

GIT1 Phosphorylation on Serine 46 by PKD3 Regulates Paxillin Trafficking and Cellular Protrusive Activity

(2012) Bettina Huck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adaptor Protein and Arf GTPase-activating Protein Cat-1/Git-1 Is Required for Cellular Transformation

(2012) Sungsoo M. Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2

(2012) Y. Xiong et al.   JOURNAL OF NEUROSCIENCE

GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production

(2012) Yuichi Mazaki et al.   MOLECULAR BIOLOGY OF THE CELL

GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

(2012) Klodjan Stafa et al.   PLoS Genetics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular organization and plasticity of the cytomatrix at the active zone

(2011) Eckart D Gundelfinger et al.   CURRENT OPINION IN NEUROBIOLOGY

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

(2011) Ger J.A. Ramakers et al.   HUMAN MOLECULAR GENETICS

 -Pix Modulates Actin-Mediated Recruitment of Synaptic Vesicles to Synapses

(2011) Y. Sun et al.   JOURNAL OF NEUROSCIENCE

Toward an understanding of the protein interaction network of the human liver

(2011) J. Wang et al.   Molecular Systems Biology

Modeling hyperactivity: of mice and men

(2011) Yong-Seok Lee et al.   NATURE MEDICINE

GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

(2011) Hyejung Won et al.   NATURE MEDICINE

xGit2 and xRhoGAP 11A regulate convergent extension and tissue separation in Xenopus gastrulation

(2010) Isabelle Köster et al.   DEVELOPMENTAL BIOLOGY

The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development

(2010) Jianxin A. Yu et al.   DEVELOPMENTAL BIOLOGY

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass

(2010) Prashanthi Menon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural Basis for Asymmetric Association of the βPIX Coiled Coil and Shank PDZ

(2010) Young Jun Im et al.   JOURNAL OF MOLECULAR BIOLOGY

NOS1AP Associates with Scribble and Regulates Dendritic Spine Development

(2010) L. Richier et al.   JOURNAL OF NEUROSCIENCE

A Robust Protocol to Map Binding Sites of the 14-3-3 Interactome: Cdc25C Requires Phosphorylation of Both S216 and S263 to bind 14-3-3

(2010) Perry M. Chan et al.   MOLECULAR & CELLULAR PROTEOMICS

p21-Activated Kinases 1 and 3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties

(2010) W. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of Nonapoptotic Cell Death by Activated Ras Requires Inverse Regulation of Rac1 and Arf6

(2010) Haymanti Bhanot et al.   MOLECULAR CANCER RESEARCH

Regulation of thymocyte positive selection and motility by GIT2

(2010) Hyewon Phee et al.   NATURE IMMUNOLOGY

A Vertebrate-Specific Chp-PAK-PIX Pathway Maintains E-Cadherin at Adherens Junctions during Zebrafish Epiboly

(2010) Hwee Goon Tay et al.   PLoS One

ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2

(2010) Karina Haebig et al.   PLoS One

The role of β1Pix/caveolin-1 interaction in endothelin signaling through Gα subunits

(2009) Ahmed Chahdi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells

(2009) Manuela Gavina et al.   BIOLOGY OF THE CELL

GIT1 is a Novel MEK1-ERK1/2 Scaffold that Localizes to Focal Adhesions

(2009) Ning Zhang et al.   CELL BIOLOGY INTERNATIONAL

Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of β1Pix/Gαi3 interaction

(2009) Ahmed Chahdi et al.   CELLULAR SIGNALLING

G-Protein–Coupled Receptor Kinase Interacting Protein-1 Is Required for Pulmonary Vascular Development

(2009) Jinjiang Pang et al.   CIRCULATION

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling

(2009) A. Hajdo-Milasinovic et al.   JOURNAL OF CELL SCIENCE

 PIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells

(2009) F. Momboisse et al.   JOURNAL OF CELL SCIENCE

α Pix enhances mutant huntingtin aggregation

(2009) Makoto Eriguchi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell–Cell Contacts

(2009) Koichi Miura et al.   MOLECULAR BIOLOGY OF THE CELL

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Impaired fear response in mice lacking GIT1

(2009) Robert Schmalzigaug et al.   NEUROSCIENCE LETTERS

Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts

(2009) T. Heckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis

(2008) Sami M. Bahri et al.   DEVELOPMENTAL BIOLOGY

An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor

(2008) Megan E. Cavet et al.   FASEB JOURNAL

GIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 Motifs

(2008) Ziwei M. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consensus nomenclature for the human ArfGAP domain-containing proteins

(2008) Richard A. Kahn et al.   JOURNAL OF CELL BIOLOGY

Structures of Dimeric GIT1 and Trimeric β-PIX and Implications for GIT–PIX Complex Assembly

(2008) Oliver Schlenker et al.   JOURNAL OF MOLECULAR BIOLOGY

 PIX Rho GTPase Guanine Nucleotide Exchange Factor Regulates Lymphocyte Functions and Antigen Receptor Signaling

(2008) K. Missy et al.   MOLECULAR AND CELLULAR BIOLOGY

Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex

(2008) Takeo Saneyoshi et al.   NEURON

Anxiety-like behaviors in mice lacking GIT2

(2008) Robert Schmalzigaug et al.   NEUROSCIENCE LETTERS

The PIX–GIT complex: A G protein signaling cassette in control of cell shape

(2008) Scott R. Frank et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A RAC/CDC-42–Independent GIT/PIX/PAK Signaling Pathway Mediates Cell Migration in C. elegans

(2008) Mark Lucanic et al.   PLoS Genetics