Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts

(2014) K.-W. Lee et al.   CANCER RESEARCH

Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis

(2014) J. Stanisavljevic et al.   CANCER RESEARCH

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion

(2014) Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

(2014) Maureen Cetera et al.   Nature Communications

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting (FACS)

(2013) Yoray Sharon et al.   Jove-Journal of Visualized Experiments

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells

(2012) R Batlle et al.   ONCOGENE

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation

(2011) Kun Zhang et al.   EMBO JOURNAL

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

A Multifunctional Lentiviral-Based Gene Knockdown with Concurrent Rescue that Controls for Off-Target Effects of RNAi

(2011) Yunfeng Feng et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Comparison of 2D fiber network orientation measurement methods

(2008) E. A. Sander et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Snail promotes Wnt target gene expression and interacts with β-catenin

(2008) V Stemmer et al.   ONCOGENE