Article
Cell Biology
Juan Jose Perez-Moreno, Carmen Santa-Cruz Mateos, Maria Dolores Martin-Bermudo, Beatriz Estrada
Summary: Muscle development is a complex process involving cell specification, myoblast fusion, myotube migration, and attachment to tendons. The molecular mechanisms underlying myotube migration are not well understood, but studies in Drosophila have identified some molecular signals involved in this process. Laminins and Kon-tiki/Perdido have been found to play important roles in controlling both myotube migration and attachment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenjing Li, Tianlong Zhang, Mingliang Sun, Yu Shi, Xiao-Jie Zhang, Guo-Liang Xu, Jianping Ding
Summary: This study elucidates the molecular mechanism of CMD1-catalyzed C-5-glyceryl-methylcytosine (5gmC) DNA modification. CMD1 exhibits high binding affinities for DNA and moderate substrate preference for DNA containing 5mCpG.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Shu-Quan Zhang, Yu Cui, Xue-Wei Li, Yong Sun, Zi-Wu Wang
Summary: Research has shown that multiphonon processes play a role in electron transfer as quickly as single phonon processes, suggesting that different phonon modes of odorant molecules should be considered in electron transfer in olfaction. The temperature dependence of electron transfer can be effectively analyzed by expanding the reorganization energy into the linewidth of multiphonon processes. The theoretical results not only enrich the understanding of olfactory recognition mechanisms, but also provide insights into quantum processes in biological systems.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Review
Plant Sciences
Na Wang, Xianlei Wang, Mengjiao He, Wenxiu Zheng, Dongmei Qi, Yongqing Zhang, Chun-chao Han
Summary: The treatment of nervous system diseases has long been a challenging issue for researchers due to their complexity, but with the aging society, there is a growing interest in finding effective treatments. Ginseng polysaccharides have shown potential in immune regulation, antioxidant properties, and anti-inflammatory effects. Studies have revealed that ginseng polysaccharides may play a role in ameliorating nervous system diseases through immune system regulation, inflammatory response, and oxidative damage.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biology
Neale J. Harrison, Elizabeth Connolly, Alicia Gascon Gubieda, Zidan Yang, Benjamin Altenhein, Maria Losada Perez, Marta Moreira, Jun Sun, Alicia Hidalgo
Summary: Understanding the relationship between Drosophila neurogenesis-related genes and glial cells reveals that la-2 and Dilp-6 drive the reprogramming of glial cells into neural stem cells for regeneration.
Review
Medicine, Research & Experimental
Yishu Fan, Zhuohui Chen, Mengqi Zhang
Summary: Exosomes, cell-derived extracellular vesicles, have been found to play a significant role in the pathogenesis and potential treatment of CNS diseases, by transferring biologically active molecules between different cells and delivering drugs across the blood brain barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Kaiyan Tao, Xuefeng Wang, Xin Tian
Summary: Primary Central Nervous System Lymphoma (PCNSL) relapses are often derived from occult lymphoma cells, with treatment options including chemotherapy, radiation therapy, stem cell transplantation, targeted therapy, and immunotherapy. The overall prognosis is very poor, with early and varied clinical symptoms.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Lorena R. Lizarraga-Valderrama
Summary: Essential oils have a wide range of biological activities and can produce anxiolytic, antidepressant, sedative, and anticonvulsant effects on the nervous system. Animal models have shown involvement of multiple neurotransmitter systems leading to measurable physiological effects in the brain, and clinical trials have demonstrated their influence on physiological parameters and psychological effects. More research is needed to validate their influence on the human central nervous system and their potential as drugs for mental illnesses.
PHYTOTHERAPY RESEARCH
(2021)
Review
Engineering, Biomedical
Jingtao Wang, Lingyan Yang
Summary: Exosomes are membrane-bound vesicles that contain bioactive molecules and can mediate various biological processes. They can cross the blood-brain barrier and have the potential for CNS disease therapy by promoting tissue regeneration and repair. Loading exosomes with therapeutic agents and engineering specific functional and administration routes are discussed as strategies to treat neurodegenerative disease or spinal cord injury using different exosomes derived from various cell types.
BIOMEDICAL MATERIALS
(2023)
Review
Physiology
Guo-liang Zhang, Ming-li Sun, Xin-an Zhang
Summary: The loss of cardiomyocytes is a key factor in cardiovascular diseases leading to heart failure, and exercise can enhance the proliferative potential of adult cardiomyocytes to promote myocardial regeneration. By regulating cytokines and miRNAs, exercise can induce dedifferentiation and proliferation of existing cardiomyocytes to form new ones.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Genetics & Heredity
Juan Carlos Duhart, Timothy J. Mosca
Summary: The goal of modern neuroscience is to understand how connections form and function in the brain. Studying the nervous system in fruit flies has led to the discovery of molecular and genetic mechanisms underlying synapse development. In the past, research focused on the neuromuscular junction, but recent tools and techniques have allowed for a clearer understanding of synapse formation in the central nervous system. The use of fruit flies as a genetic model has provided novel insights into neural development.
Article
Biotechnology & Applied Microbiology
Wenbiao Zhang, Yongjiang Li, Guanjun Chen, Xiaochun Yang, Junfeng Hu, Xiaofei Zhang, Guokai Feng, Hua Wang
Summary: In this study, three integrin alpha 6-targeted molecular imaging agents were used to accurately detect central nervous system leukemia (CNS-L) in mice, showing promising results with strong imaging signals compared to clinically available imaging models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Ibrar Muhammad Khan, Safir Ullah Khan, Hari Siva Sai Sala, Munir Ullah Khan, Muhammad Azhar Ud Din, Samiullah Khan, Syed Shams ul Hassan, Nazir Muhammad Khan, Yong Liu
Summary: The tumor microenvironment plays a crucial role in the development, metastasis, and response to therapy of tumors. By studying the pathogenesis, changes in the microenvironment, and new treatment methods of brain metastases, the paper reveals the development rules and key driving factors of the disease, and promotes the clinical precision medicine of brain metastases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Xiaowen Huang, Basharat Hussain, Junlei Chang
Summary: The blood-brain barrier is a crucial physiological barrier that separates the central nervous system from the peripheral circulation. Disruption of the BBB by peripheral inflammation can lead to various CNS diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Clinical Neurology
Isaias Hernandez-Verdin, Andrea Morales-Martinez, Khe Hoang-Xuan, Agusti Alentorn
Summary: Recent studies have revealed four distinct molecular subtypes of PCNSL with prognostic relevance, highlighting the importance of the tumor microenvironment (TME) as a driving prognostic factor. Therapeutic efforts are focused on targeting the NF-kappa beta pathway or modulating the TME through immunomodulatory drugs or immunotherapy. Further research is needed to develop diagnostic biomarkers for detecting PCNSL and its molecular subtypes in routine clinical use.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Cell Biology
Istvan Foldi, Niki Anthoney, Neale Harrison, Monique Gangloff, Brett Verstak, Mohanakarthik Ponnadai Nallasivan, Samaher AlAhmed, Bangfu Zhu, Mark Phizacklea, Maria Losada-Perez, Marta Moreira, Nicholas J. Gay, Alicia Hidalgo
JOURNAL OF CELL BIOLOGY
(2017)
Review
Cell Biology
Maria Losada-Perez, Neale Harrison, Alicia Hidalgo
NEURAL REGENERATION RESEARCH
(2017)
Article
Genetics & Heredity
Suzana Ulian-Benitez, Simon Bishop, Istvan Foldi, Jill Wentzell, Chinenye Okenwa, Manuel G. Forero, Bangfu Zhu, Marta Moreira, Mark Phizacklea, Graham McIlroy, Guiyi Li, Nicholas J. Gay, Alicia Hidalgo
Article
Developmental Biology
Niki Anthoney, Istvan Foldi, Alicia Hidalgo
Review
Genetics & Heredity
Maria Losada-Perez
JOURNAL OF NEUROGENETICS
(2018)
Article
Multidisciplinary Sciences
Hugo Gabilondo, Irene Rubio-Ferrera, Maria Losada-Perez, Delia del Saz, Yolanda Leon, Isabel Molina, Laura Torroja, Douglas W. Allan, Jonathan Benito-Sipos
Article
Biochemistry & Molecular Biology
Marta Portela, Varun Venkataramani, Natasha Fahey-Lozano, Esther Seco, Maria Losada-Perez, Frank Winkler, Sergio Casas-Tinto
Article
Cell Biology
Maria Losada-Perez, Nuria Garcia-Guillen, Sergio Casas-Tinto
Summary: The article introduces a new experimental design to damage the mammalian central nervous system through a contusion injury paradigm. It demonstrates that adult Drosophila melanogaster glial cells undergo spontaneous functional recovery after injury and analyzes the role of immune cells in functional regeneration.
DISEASE MODELS & MECHANISMS
(2021)
Review
Biochemistry & Molecular Biology
Teresa de los Reyes Corrales, Maria Losada-Perez, Sergio Casas-Tinto
Summary: The JNK signaling pathway is crucial in the central nervous system, playing a central role in combating pathophysiological insults during development and adulthood. It is involved in various diseases such as glioblastoma, regeneration/repair after injury, neurodegeneration, and neuronal cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Maria Losada-Perez, Mamen Hernandez Garcia-Moreno, Irene Garcia-Ricote, Sergio Casas-Tinto
Summary: Glioblastoma is an aggressive and lethal brain tumor that interacts with healthy surrounding tissues through cell communication and synapses, promoting tumor expansion and neurodegeneration.
Article
Psychology, Experimental
Patrick K. Durkee, Pablo Polo, Jose Antonio Munoz-Reyes, Claudia Rodriguez-Ruiz, Maria Losada-Perez, Ana B. Fernandez-Martinez, Enrique Turiegano, David M. Buss, Miguel Pita
EVOLUTIONARY PSYCHOLOGY
(2019)
Review
Anatomy & Morphology
Kentaro Kato, Maria Losada-Perez, Alicia Hidalgo
DEVELOPMENTAL DYNAMICS
(2018)