MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury

Membrane-delimited signaling and cytosolic action of MG53 preserve hepatocyte integrity during drug-induced liver injury

(2021) Yu Han et al.   JOURNAL OF HEPATOLOGY

MG53 does not manifest the development of diabetes in db/db mice

(2020) Qiang Wang et al.   DIABETES

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells

(2020) Bing-chuan Geng et al.   ACTA PHARMACOLOGICA SINICA

Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H 2 O 2 -Activated PKC-δ Signaling

(2020) Dan Shan et al.   CIRCULATION

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

(2020) Xingyan Li et al.   Nature Communications

MG53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling

(2019) T. M. Ayodele Adesanya et al.   Journal of the American Heart Association

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

(2019) Zehua Bian et al.   Nature Communications

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

(2019) Xixi Zhang et al.   Nature Communications

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

(2018) Alessandro Annibaldi et al.   MOLECULAR CELL

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2017) Ran Wei et al.   GENES & DEVELOPMENT

Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B

(2017) Liubov V. Gushchina et al.   MOLECULAR THERAPY

Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor

(2016) Frances A. Lemckert et al.   CARDIOVASCULAR RESEARCH

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

(2016) M Cristina de Almagro et al.   CELL DEATH AND DIFFERENTIATION

Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche

(2016) Koyal Garg et al.   JOURNAL OF APPLIED PHYSIOLOGY

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

(2016) Subrata Kumar Biswas   Oxidative Medicine and Cellular Longevity

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

(2016) Sha Li et al.   Oxidative Medicine and Cellular Longevity

MG53 permeates through blood-brain barrier to protect ischemic brain injury

(2016) Yonggang Yao et al.   Oncotarget

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants and coronary artery disease

(2015) Jane A. Leopold   CORONARY ARTERY DISEASE

Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes

(2015) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury

(2015) Jianxun Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein

(2015) Hua Zhu et al.   MUSCLE & NERVE

Effect of Metabolic Syndrome on Mitsugumin 53 Expression and Function

(2015) Hanley Ma et al.   PLoS One

MG53-mediated cell membrane repair protects against acute kidney injury

(2015) Pu Duann et al.   Science Translational Medicine

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

(2014) Yanlin Jia et al.   Nature Communications

Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis

(2013) Nga Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair

(2012) Peihui Lin et al.   FASEB JOURNAL

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters

(2012) Bo He et al.   MOLECULAR THERAPY

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

(2012) N. Weisleder et al.   Science Translational Medicine

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair

(2011) Moonsun Hwang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MG53 participates in ischaemic postconditioning through the RISK signalling pathway

(2011) Yan Zhang et al.   CARDIOVASCULAR RESEARCH

Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair

(2011) Hua Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning

(2010) Chun-Mei Cao et al.   CIRCULATION

Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair

(2010) Xianhua Wang et al.   CIRCULATION RESEARCH

Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis

(2010) Richard F. Loeser   CLINICS IN GERIATRIC MEDICINE

Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin

(2009) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells

(2008) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY