In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

(2022) Nehad M. El-Dydamony et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

(2021) Le Yu et al.   SEMINARS IN CANCER BIOLOGY

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

(2021) Prisca Lagardère et al.   Pharmaceuticals

Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells

(2020) Meng Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

(2020) Ningni Jiang et al.   MOLECULAR BIOLOGY REPORTS

Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking

(2020) Amira A. Helwa et al.   BIOORGANIC CHEMISTRY

Design, synthesis and evaluation of novel thienopyrimidine-based agents bearing diaryl urea functionality as potential inhibitors of angiogenesis

(2020) Aram Faraji et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

(2019) Eslam M.H. Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies

(2019) Mai S. El-Shoukrofy et al.   BIOORGANIC CHEMISTRY

Synthesis and Screening of Phosphodiesterase 5 Inhibitory Activity of Fused and Isolated Triazoles Based on Thieno[2,3‐ d ]pyrimidines

(2019) Mohamed A. Ameen et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Akt in cancer: Mediator and more

(2019) Sundaramoorthy Revathidevi et al.   SEMINARS IN CANCER BIOLOGY

Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells

(2019) Yu-Han Chen et al.   Scientific Reports

Design, Synthesis, and Biological Evaluation of Novel Thienopyrimidine Derivatives as PI3Kα Inhibitors

(2019) Lide Yu et al.   MOLECULES

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors

(2019) Wenhu Zhan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

(2019) Ruifeng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

(2018) Mehlika Altıntop et al.   MOLECULES

Inhibition of the PI3K/Akt signaling pathway reverses sorafenib‑derived chemo‑resistance in hepatocellular carcinoma

(2018) Hao Zhang et al.   Oncology Letters

Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents

(2018) Amna Ghith et al.   BIOORGANIC CHEMISTRY

Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe

(2017) Haneen Amawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Newest Developments in the Preparation of Thieno[2,3-d]pyrimidines

(2017) B. Wilding et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Maximising the potential of AKT inhibitors as anti-cancer treatments

(2017) Jessica S. Brown et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3- d ]pyrimidin-4(3 H )-one schiff bases

(2016) Malothu Narender et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Synthesis, Anticancer Activity, Effect on Cell Cycle Profile, and Apoptosis-Inducing Ability of Novel Hexahydrocyclooctathieno[2,3-d]pyrimidine Derivatives

(2016) Asmaa Elsayed Kassab et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties

(2015) Khurshed Bozorov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantitation of VEGFR2 (vascular endothelial growth factor receptor) inhibitors - review of assay methodologies and perspectives

(2014) Kuldeep Sharma et al.   BIOMEDICAL CHROMATOGRAPHY

Molecular design and synthesis of 1,4-disubstituted piperazines as α1-adrenergic receptor blockers

(2014) Dalal A. Abou El-Ella et al.   BIOORGANIC CHEMISTRY

Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents

(2014) Ahmed Temirak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206

(2014) Mohd Rehan et al.   PLoS One

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

(2013) Xiaoke Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Study of the Antidepressant Activity of 4-Phenyl-2-thioxo-benzo[4,5]thieno[2,3-d]pyrimidine Derivatives

(2012) Victoriano Darias et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Synthesis and anti-tumor activities of N′-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives

(2011) Jiangping Lou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signaling Pathways Governing Tumor Angiogenesis

(2011) Toshiharu Sakurai et al.   ONCOLOGY

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

(2010) Daniel P. Sutherlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

(2009) Kristy J. Gotink et al.   ANGIOGENESIS

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

(2009) Steven W. Kortum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo

(2009) Richard W.A. Luke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop

(2009) Oscar Gonzalez-Moreno et al.   EXPERIMENTAL CELL RESEARCH

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

(2008) T. Yi et al.   MOLECULAR CANCER THERAPEUTICS