Article
Cell & Tissue Engineering
Shijia Liuyang, Guan Wang, Yanglu Wang, Huanjing He, Yulin Lyu, Lin Cheng, Zhihan Yang, Jingyang Guan, Yao Fu, Jialiang Zhu, Xinxing Zhong, Shicheng Sun, Cheng Li, Jinlin Wang, Hongkui Deng
Summary: We have developed a robust and chemically defined reprogramming protocol that significantly shortens the induction time for generating human pluripotent stem cells from somatic cells. This protocol promotes cell proliferation and metabolic activities, leading to a more direct reprogramming process.
Article
Pharmacology & Pharmacy
Ruohan Zhang, Serra Ozgen, Hongke Luo, Judith Krigman, Yutong Zhao, Gang Xin, Nuo Sun
Summary: In this study, the researchers investigate the role of Parkin and USP30 in regulating the AKT/mTOR signaling during mitophagy. They found that Parkin inhibits AKT/mTOR signaling, while USP30 antagonizes the activity of Parkin to sustain AKT/mTOR activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ya Hou, Yating Zhang, Shengnan Jiang, Na Xie, Yi Zhang, Xianli Meng, Xiaobo Wang
Summary: This study aimed to investigate the mechanisms by which Salidroside enhances mitochondrial function in CoCl2-induced HT22 hypoxic injury. The results showed that Salidroside can reduce oxidative damage, decrease ROS and Ca2+ levels, and enhance mitochondrial membrane potential and cell viability.
Article
Multidisciplinary Sciences
Sam Buckberry, Xiaodong Liu, Daniel Poppe, Jia Ping Tan, Guizhi Sun, Joseph Chen, Trung Viet Nguyen, Alex de Mendoza, Jahnvi Pflueger, Thomas Frazer, Dulce B. Vargas-Landin, Jacob M. Paynter, Nathan Smits, Ning Liu, John F. Ouyang, Fernando J. Rossello, Hun S. Chy, Owen J. L. Rackham, Andrew L. Laslett, James Breen, Geoffrey J. Faulkner, Christian M. Nefzger, Jose M. Polo, Ryan Lister
Summary: Cells undergo a significant epigenome reconfiguration during reprogramming to hiPS cells. The differences in epigenomes between hiPS cells and hES cells affect the function of hiPS cells. Researchers characterized the emergence and persistence of these epigenetic differences and developed a TNT reprogramming strategy that corrects epigenetic memory and aberrations, making hiPS cells more similar to hES cells at a molecular and functional level.
Article
Medicine, Research & Experimental
Chunhua Bai, Jiaqi Zhao, Jielin Su, Jiaxin Chen, Xinmu Cui, Manqing Sun, Xuewu Zhang
Summary: The study demonstrated that curcumin triggers mitochondrial apoptosis in HCC by inhibiting the PI3K/AKT/GSK-3 beta signaling pathway and downregulating BCLAF1 expression, thereby inhibiting tumor growth. This highlights a potential therapeutic strategy leveraging the antitumor effects of curcumin against HCC.
Article
Agriculture, Dairy & Animal Science
Wennan Li, Wei Yan, Fei Hao, Lingyun Hao, Dongjun Liu
Summary: This study found that increasing the level of crotonylation can promote the reprogramming of somatic cells and the development of cloned embryos in Cashmere goats. This finding provides an important reference for improving the efficiency of in vitro Cashmere goat somatic cell nuclear transfer embryo production.
Article
Multidisciplinary Sciences
Xingyuan Zhai, Kai Liu, Hongkun Fang, Quan Zhang, Xianjun Gao, Fang Liu, Shangshang Zhou, Xinming Wang, Yujia Niu, Yazhen Hong, Shu-Hai Lin, Wen-Hsien Liu, Changchun Xiao, Qiyuan Li, Nengming Xiao
Summary: C1qbp plays a crucial role in the differentiation of effector CD8(+) T cells by regulating mitochondrial oxidative phosphorylation, affecting levels of acetyl-coenzyme A and fumarate, influencing the methylation status of H3K27, and impacting the transcriptional levels of effector genes.
Article
Biotechnology & Applied Microbiology
Soo Jin Park, Joo-Hyun Kim, Sangtaek Oh, Do Yup Lee
Summary: A family of signaling pathways called Wnt signaling pathways play a crucial role in developmental processes such as cell division and proliferation. Mutations in these pathways can lead to various diseases, including cancer, metabolic disorders, and neurodegenerative diseases. However, the complexity of these pathways makes it challenging to identify specific metabolic targets. In this study, the researchers used high-throughput and un-targeted metabolite profiling to investigate the metabolic regulation caused by the overexpression of the Wnt signaling pathway. They identified significant changes in central carbon/nitrogen metabolism pathways and fatty acid pathways. The findings provide a detailed understanding of the biochemical dynamics in response to Wnt-driven metabolic changes, which could help in the development of precise therapeutic targets for Wnt-related diseases.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Tong Feng, Ran Duan, Pengcheng Zheng, Jing Qiu, Qingyuan Li, Wancheng Li
Summary: This study found that oxymatrine (OMT) can reduce transforming growth factor-beta 1 (TGF-beta 1)-induced pulmonary fibrosis (PF) by inhibiting apoptosis and targeting the PI3K/AKT pathway. OMT protects cells against TGF-beta 1-induced injury by improving mitochondrial function, regulating the expression of Bax and Bcl-2.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell Biology
Jing Zhao, Hua-qing Yu, Feng-qin Ge, Man-ru Zhang, Yu-chen Song, Dan-dan Guo, Qi-hang Li, Hua Zhu, Peng-zhou Hang
Summary: It has been found that 7,8,3'-Trihydroxyflavone (THF) can alleviate doxorubicin (DOX)-induced cardiotoxicity and improve mitochondrial function by activating Akt-mediated Mfn2 and HO-1 pathways.
CELLULAR SIGNALLING
(2023)
Article
Immunology
Bo-Ram Bang, Haruka Miki, Young Jun Kang
Summary: PGAM5-Drp1 signaling regulates mitochondrial dynamics and downstream signaling pathways to induce inflammation in macrophages, while also promoting metabolic reprogramming.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Li Zhang, Chi-Lam Au-Yeung, Chunxian Huang, Tsz-Lun Yeung, Sammy Ferri-Borgogno, Barrett C. Lawson, Suet-Ying Kwan, Zheng Yin, Stephen T. Wong, Vienna Thomas, Karen H. Lu, Kay-Pong Yip, James S. K. Sham, Samuel C. Mok
Summary: This study identified the role of ryanodine receptor 1 (RYR1) in uterine serous cancer (USC) progression and demonstrated the efficacy of the repositioned compound dantrolene in treating USC. Inhibition of RYR1 suppressed USC cell proliferation and migration and enhanced apoptosis. The findings provide insight into the mechanism by which RYR1 modulates USC progression and suggest dantrolene as a potential therapeutic agent for improving patient survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Anatomy & Morphology
Xiaocong Liu, Yuanyuan Zhang, Xiaoyan Yang, Yan Zhang, Yulan Liu, Li Wang, Ting Yi, Jing Yuan, Wu Wen, Yi Jian
Summary: The study reveals the anti-tumor potential of mitochondrial transplantation by regulating cellular oxidative stress in cholangiocarcinoma through the PTEN/PI3K/AKT signaling pathway.
Article
Multidisciplinary Sciences
Uxue Ulanga, Matthew Russell, Stefano Patassini, Julie Brazzatti, Ciaren Graham, Anthony D. Whetton, Robert L. J. Graham
Summary: Murine models are widely used in biology and pathology research, and targeted quantitative proteomic analysis is a new tool. SWATH-MS technique requires prior acquisition of mass spectra to generate an assay reference library. Inducing pluripotency from fibroblast population leads to major changes in expressed proteins, and a reference library has been created to support such studies.
Article
Multidisciplinary Sciences
Wei Wei, Daniel J. Gaffney, Patrick F. Chinnery
Summary: Analysis of mtDNA in a large number of iPSC lines reveals that iPSC-specific mutations affect a higher proportion of mtDNA molecules, favoring non-synonymous protein-coding and tRNA variants. Additionally, stable heteroplasmy in mtDNA variants during cell differentiation influences mitochondrial metabolism and cell differentiation.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Brian A. Pedersen, Weiwen Wang, Jared F. Taylor, Omar S. Khattab, Yu-Han Chen, Robert A. Edwards, Puya G. Yazdi, Ping H. Wang
METABOLISM-CLINICAL AND EXPERIMENTAL
(2015)
Article
Medicine, Research & Experimental
Yang Cao, Lingyi Tang, Kang Du, Kitt Paraiso, Qiushi Sun, Zhengxia Liu, Xiaolong Ye, Yuan Fang, Fang Yuan, Hank Chen, Yumay Chen, Xiaorong Wang, Clinton Yu, Ira L. Blitz, Ping H. Wang, Lan Huang, Haibo Cheng, Xiang Lu, Ken W. Y. Cho, Marcus Seldin, Zhuyuan Fang, Qin Yang
Summary: LSD1 regulates mitochondrial function and hepatokine production by modulating histone methylation and NAD+ synthesis. Deletion of LSD1 in mice reduces mitochondrial function in the liver but protects against diet-induced hepatic steatosis and glucose intolerance, partially due to the induction of the hepatokine FGF21.