A network model of glymphatic flow under different experimentally-motivated parametric scenarios

Mapping of CSF transport using high spatiotemporal resolution dynamic contrast‐enhanced MRI in mice: Effect of anesthesia

(2021) Evan Hunter Stanton et al.   MAGNETIC RESONANCE IN MEDICINE

Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain

(2021) Daniel E. Troyetsky et al.   Scientific Reports

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

(2021) Aditya Raghunandan et al.   eLife

Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature

(2020) Christoph Kirst et al.   CELL

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Visualization and molecular characterization of whole-brain vascular networks with capillary resolution

(2020) Takeyuki Miyawaki et al.   Nature Communications

Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

(2020) Sunil Koundal et al.   Scientific Reports

Intracranial pressure elevation alters CSF clearance pathways

(2020) Vegard Vinje et al.   Fluids and Barriers of the CNS

Clearance of two organic nanoparticles from the brain via the paravascular pathway

(2020) Xiao Gu et al.   JOURNAL OF CONTROLLED RELEASE

Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular‐interstitial flux through the cortical mantle

(2020) Marie Xun Wang et al.   GLIA

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

Circadian control of brain glymphatic and lymphatic fluid flow

(2020) Lauren M. Hablitz et al.   Nature Communications

Functional hyperemia drives fluid exchange in the paravascular space

(2020) Ravi Teja Kedarasetti et al.   Fluids and Barriers of the CNS

Direct Measurement of Cerebrospinal Fluid Production in Mice

(2020) Guojun Liu et al.   Cell Reports

Sleep deprivation impairs molecular clearance from the human brain

(2020) Per Kristian Eide et al.   BRAIN

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

(2019) Lauren M. Hablitz et al.   Science Advances

Mathematical synthesis of the cortical circulation for the whole mouse brain-part I. theory and image integration

(2019) Andreas Linninger et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Hydraulic resistance of periarterial spaces in the brain

(2019) Jeffrey Tithof et al.   Fluids and Barriers of the CNS

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system

(2019) M. Keith Sharp et al.   Fluids and Barriers of the CNS

Glymphatic imaging using MRI

(2019) Toshiaki Taoka et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Computational modelling of fluid and solute transport in the brain

(2019) Adam D. Martinac et al.   Biomechanics and Modeling in Mechanobiology

Fluid dynamics of cerebrospinal fluid flow in perivascular spaces

(2019) John H. Thomas   Journal of the Royal Society Interface

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy

(2018) Molly J. Sullan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Porosity–Permeability Relations for Evolving Pore Space: A Review with a Focus on (Bio-)geochemically Altered Porous Media

(2018) Johannes Hommel et al.   TRANSPORT IN POROUS MEDIA

The pial vasculature of the mouse develops according to a sensory-independent program

(2018) Matthew D. Adams et al.   Scientific Reports

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Molecular characterization of perivascular drainage pathways in the murine brain

(2017) Melanie-Jane Hannocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache

(2017) Aaron J. Schain et al.   JOURNAL OF NEUROSCIENCE

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

(2017) Hedok Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

A novel method to study cerebrospinal fluid dynamics in rats

(2015) Jason K. Karimy et al.   JOURNAL OF NEUROSCIENCE METHODS

How astrocyte networks may contribute to cerebral metabolite clearance

(2015) Mahdi Asgari et al.   Scientific Reports

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI

(2014) Thomas Gaberel et al.   STROKE

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

(2013) Pablo Blinder et al.   NATURE NEUROSCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Topological basis for the robust distribution of blood to rodent neocortex

(2010) Pablo Blinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Physics of Hydrocephalus

(2009) Richard D. Penn et al.   PEDIATRIC NEUROSURGERY