Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI

(2019) Sunil Koundal et al.   NEUROSCIENCE

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

(2019) Kristian Nygaard Mortensen et al.   JOURNAL OF NEUROSCIENCE

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system

(2019) M. Keith Sharp et al.   Fluids and Barriers of the CNS

CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent

(2019) Alex J. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rebuttal from Matthew Simon and Jeffrey Iliff

(2019) Matthew Simon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rebuttal from Alex J. Smith and Alan S. Verkman

(2019) Alex J. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Understanding the role of the perivascular space in cerebral small vessel disease

(2018) Rosalind Brown et al.   CARDIOVASCULAR RESEARCH

Interpolation of matrices and matrix-valued densities: The unbalanced case

(2018) YONGXIN CHEN et al.   EUROPEAN JOURNAL OF APPLIED MATHEMATICS

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study

(2018) Per K Eide et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An Efficient Algorithm for Matrix-Valued and Vector-Valued Optimal Mass Transport

(2018) Yongxin Chen et al.   JOURNAL OF SCIENTIFIC COMPUTING

Quantitative MRI of Perivascular Spaces at 3T for Early Diagnosis of Mild Cognitive Impairment

(2018) M. Niazi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Modeling glymphatic system of the brain using MRI

(2018) Esmaeil Davoodi-Bojd et al.   NEUROIMAGE

Optimal Mass Transport: Signal processing and machine-learning applications

(2017) Soheil Kolouri et al.   IEEE SIGNAL PROCESSING MAGAZINE

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

(2017) Hedok Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport

(2017) Vadim Ratner et al.   NEUROIMAGE

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Joint hydrogeophysical inversion: state estimation for seawater intrusion models in 3D

(2016) Klara Steklova et al.   COMPUTATIONAL GEOSCIENCES

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

(2016) Weiguo Peng et al.   NEUROBIOLOGY OF DISEASE

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

The Effect of Body Posture on Brain Glymphatic Transport

(2015) H. Lee et al.   JOURNAL OF NEUROSCIENCE

On the Relation Between Optimal Transport and Schrödinger Bridges: A Stochastic Control Viewpoint

(2015) Yongxin Chen et al.   JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS

Waxholm Space atlas of the rat brain hippocampal region: Three-dimensional delineations based on magnetic resonance and diffusion tensor imaging

(2015) Lisa J. Kjonigsen et al.   NEUROIMAGE

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke

(2014) Hugo Pedder et al.   STROKE

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space

(2008) Sumeet Gupta et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME