FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin

Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors

(2021) Gian Marco Elisi et al.   Journal of Chemical Information and Modeling

Shedding new light on the generation of the visual chromophore

(2020) Krzysztof Palczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metadynamics simulations of ligand binding to GPCRs

(2019) Passainte Ibrahim et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Does the lipid bilayer orchestrate access and binding of ligands to transmembrane orthosteric/allosteric sites of GPCRs?

(2019) Christopher Tytus Szlenk et al.   MOLECULAR PHARMACOLOGY

Shift in Conformational Equilibrium Induces Constitutive Activity of G-Protein-Coupled Receptor, Rhodopsin

(2018) Ryo Maeda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ligand channel in pharmacologically stabilized rhodopsin

(2018) Daniel Mattle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule

(2018) Michael P. Bokoch et al.   BIOCHEMISTRY

Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State

(2018) Shinya Sato et al.   JOURNAL OF NEUROSCIENCE

Conformational equilibria of light-activated rhodopsin in nanodiscs

(2017) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

(2016) Christopher T. Schafer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

(2016) Nathaniel Stanley et al.   Scientific Reports

Comparative Mutagenesis Studies of Retinal Release in Light-Activated Zebrafish Rhodopsin Using Fluorescence Spectroscopy

(2015) J. M. Morrow et al.   BIOCHEMISTRY

The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation

(2015) Elise Blankenship et al.   STRUCTURE

Origin of the low thermal isomerization rate of rhodopsin chromophore

(2015) Masataka Yanagawa et al.   Scientific Reports

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin

(2014) Christopher T. Schafer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Constitutively Activating Mutation Alters the Dynamics and Energetics of a Key Conformational Change in a Ligand-free G Protein-coupled Receptor

(2013) Hisao Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods

(2012) Rikard Frederiksen et al.   JOURNAL OF GENERAL PHYSIOLOGY

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

Effect of channel mutations on the uptake and release of the retinal ligand in opsin

(2012) R. Piechnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Measurement of Thermal Stability of Expressed CCR5 and Stabilization by Small Molecule Ligands

(2010) Adam M. Knepp et al.   BIOCHEMISTRY

Site-specific labeling of proteins with NMR-active unnatural amino acids

(2009) David H. Jones et al.   JOURNAL OF BIOMOLECULAR NMR

FTIR analysis of GPCR activation using azido probes

(2009) Shixin Ye et al.   Nature Chemical Biology

A Ligand Channel through the G Protein Coupled Receptor Opsin

(2009) Peter W. Hildebrand et al.   PLoS One

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE