Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling

Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration

(2021) Jiao Jiao et al.   BASIC RESEARCH IN CARDIOLOGY

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury

(2021) Shi-Hao Ni et al.   CARDIOVASCULAR RESEARCH

Resident cardiac macrophages mediate adaptive myocardial remodeling

(2021) Nicole R. Wong et al.   IMMUNITY

ANTAGONIZING THE CX3CR1 RECEPTOR MARKEDLY REDUCES DEVELOPMENT OF CARDIAC HYPERTROPHY AFTER TRANSVERSE AORTIC CONSTRICTION IN MICE

(2021) Simona Nemska et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

(2021) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice

(2021) Jin Bu et al.   Frontiers in Immunology

Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis

(2021) Xavier S. Revelo et al.   CIRCULATION RESEARCH

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

(2021) Liyang Fei et al.   Frontiers in Immunology

Fibroblast transdifferentiation promotes conversion of M1 macrophages and replenishment of cardiac resident macrophages following cardiac injury in mice

(2020) Hongxiang Lu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy

(2020) Zongna Ren et al.   CIRCULATION

Basic Mechanisms of Diabetic Heart Disease

(2020) Rebecca H. Ritchie et al.   CIRCULATION RESEARCH

Epidemiology of heart failure

(2020) Amy Groenewegen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

(2020) Milton Packer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

(2020) Laura Alonso-Herranz et al.   eLife

Efficacy and safety of sacubitril‐valsartan in heart failure: a meta‐analysis of randomized controlled trials

(2020) Hongzhou Zhang et al.   ESC Heart Failure

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

(2020) William P. Lafuse et al.   Cells

Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium

(2020) Rysa Zaman et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart

(2019) Gyu Seong Heo et al.   CIRCULATION RESEARCH

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

(2019) Geetika Bajpai et al.   CIRCULATION RESEARCH

The Functional Heterogeneity of Resident Cardiac Macrophages in Myocardial Injury

(2019) Bijun Chen et al.   CIRCULATION RESEARCH

Bone marrow-derived Ly6C− macrophages promote ischemia-induced chronic kidney disease

(2019) Qian Yang et al.   Cell Death & Disease

Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

(2019) Hajime Abe et al.   Nature Communications

Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac Reverse Remodeling: Meta‐Analysis

(2019) Yiwen Wang et al.   Journal of the American Heart Association

Effect of Empagliflozin on Left Ventricular Mass in Patients with Type 2 Diabetes and Coronary Artery Disease: The EMPA-HEART CardioLink-6 Randomized Clinical Trial

(2019) Subodh Verma et al.   CIRCULATION

Role of CCR2 in the Development of Streptozotocin-treated Diabetic Cardiomyopathy

(2019) Xin Tan et al.   DIABETES

An acute immune response underlies the benefit of cardiac stem-cell therapy

(2019) Ronald J. Vagnozzi et al.   NATURE

IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction

(2019) Lan Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocytes prime autoreactive T cells after myocardial infarction

(2019) Matthew DeBerge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway

(2019) Xiaopei Liu et al.   CELLULAR SIGNALLING

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload–Driven Heart Failure Reveals Extent of Immune Activation

(2019) Elisa Martini et al.   CIRCULATION

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Cardiac macrophages promote diastolic dysfunction

(2018) Maarten Hulsmans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals

(2018) Nathalie Conrad et al.   LANCET

The human heart contains distinct macrophage subsets with divergent origins and functions

(2018) Geetika Bajpai et al.   NATURE MEDICINE

Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

(2018) Xudong Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction

(2018) Jinli Wang et al.   International Journal of Nanomedicine

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells

(2017) Eszter Bakos et al.   JOURNAL OF IMMUNOLOGY

Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction

(2017) Kevin S. Shah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure

(2017) Bindiya Patel et al.   PLoS One

T cell costimulation blockade blunts pressure overload-induced heart failure

(2017) Marinos Kallikourdis et al.   Nature Communications

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart FailureNovelty and Significance

(2016) Hendrik B. Sager et al.   CIRCULATION RESEARCH

Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people

(2016) Stefan Koudstaal et al.   EUROPEAN JOURNAL OF HEART FAILURE

Monocyte and macrophage contributions to cardiac remodeling

(2016) Maarten Hulsmans et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epidemiology and aetiology of heart failure

(2016) Boback Ziaeian et al.   Nature Reviews Cardiology

β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury

(2016) Laurel A. Grisanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

(2016) Gustavo Monnerat et al.   Nature Communications

Understanding Heart Failure With Mid-Range Ejection Fraction ∗

(2016) Carolyn S.P. Lam et al.   JACC-Heart Failure

Kinetic mRNA Profiling in a Rat Model of Left-Ventricular Hypertrophy Reveals Early Expression of Chemokines and Their Receptors

(2016) Simona Nemska et al.   PLoS One

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction

(2015) Hendrik B. Sager et al.   CIRCULATION

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart FailureCLINICAL PERSPECTIVE

(2015) Tania Nevers et al.   Circulation-Heart Failure

De-novo collateral formation following acute myocardial infarction: Dependence on CCR2+ bone marrow cells

(2015) Hua Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Contemporary Appraisal of the Heart Failure Epidemic in Olmsted County, Minnesota, 2000 to 2010

(2015) Yariv Gerber et al.   JAMA Internal Medicine

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

(2014) Fanny Laroumanie et al.   CIRCULATION

Silencing of CCR2 in myocarditis

(2014) Florian Leuschner et al.   EUROPEAN HEART JOURNAL

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Pathological Ventricular Remodeling

(2013) Jana S. Burchfield et al.   CIRCULATION

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary

(2013) Clyde W. Yancy et al.   CIRCULATION

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury

(2013) Norikazu Kiguchi et al.   CYTOKINE

Benefits of   blockers in patients with heart failure and reduced ejection fraction: network meta-analysis

(2013) S. Chatterjee et al.   BMJ-British Medical Journal

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II

(2012) Feifei Ma et al.   PLoS One

CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis

(2011) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Polarized Alloantigen Presentation by Airway Epithelial Cells Contributes to Direct CD8+ T Cell Activation in the Airway

(2011) D. Kreisel et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Left Ventricular Remodeling in Heart Failure

(2011) Marvin A. Konstam et al.   JACC-Cardiovascular Imaging

TNF-α and IL-1β increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

(2010) David J. Duncan et al.   CELL CALCIUM

Effectiveness of cardiac resynchronization therapy in mild congestive heart failure: systematic review and meta-analysis of randomized trials

(2010) Steven A. Lubitz et al.   EUROPEAN JOURNAL OF HEART FAILURE

Critical Role for Leukocyte Hypoxia Inducible Factor-1α Expression in Post-Myocardial Infarction Left Ventricular Remodeling

(2009) Feng Dong et al.   CIRCULATION RESEARCH

Heart failure burden and therapy

(2009) F. Zannad et al.   EUROPACE

Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations

(2009) S. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Prevention of Disease Progression by Cardiac Resynchronization Therapy in Patients With Asymptomatic or Mildly Symptomatic Left Ventricular Dysfunction

(2009) Claude Daubert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species

(2008) Hajime Morimoto et al.   CARDIOVASCULAR RESEARCH