The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders
Authors
Keywords
-
Journal
Frontiers in Veterinary Science
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-02-15
DOI
10.3389/fvets.2022.831838
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment
- (2021) Isabel M. Guijarro et al. Biomolecules
- Abnormally abrupt transitions from sleep-to-wake in Huntington’s disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics
- (2021) William T. Schneider et al. PLoS One
- Reflections on Cerebellar Neuropathology in Classical Scrapie
- (2021) Adolfo Toledano-Díaz et al. Biomolecules
- Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease
- (2021) Samantha J. Murray et al. EXPERIMENTAL EYE RESEARCH
- Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model
- (2021) Giorgio FM Cattaneo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Natural history of Tay-Sachs disease in sheep
- (2021) Brett Story et al. MOLECULAR GENETICS AND METABOLISM
- Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease
- (2021) Szilvia Vas et al. NEUROBIOLOGY OF DISEASE
- A Multi-omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis
- (2021) Emily R. Mears et al. Journal of Huntingtons Disease
- Assessment of Glial Activation Response in the Progress of Natural Scrapie after Chronic Dexamethasone Treatment
- (2020) Isabel M. Guijarro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neuroimmune Response in Natural Preclinical Scrapie after Dexamethasone Treatment
- (2020) Isabel M. Guijarro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Comparative anatomy of the mammalian neuromuscular junction
- (2020) Ines Boehm et al. JOURNAL OF ANATOMY
- CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)
- (2019) S. L. Eaton et al. Scientific Reports
- Development of a Routinely Applicable Imaging Protocol for Fast and Precise Middle Cerebral Artery Occlusion Assessment and Perfusion Deficit Measure in an Ovine Stroke Model: A Case Study
- (2019) Andrea Maria Herrmann et al. Frontiers in Neurology
- In vivo Diffusion Tensor Magnetic Resonance Tractography of the Sheep Brain: An Atlas of the Ovine White Matter Fiber Bundles
- (2019) Valentina Pieri et al. Frontiers in Veterinary Science
- Large animal models of stroke and traumatic brain injury as translational tools
- (2018) Annabel Jain Sorby-Adams et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease
- (2018) Edith L. Pfister et al. HUMAN GENE THERAPY
- Adeno-Associated Virus Gene Therapy in a Sheep Model of Tay–Sachs Disease
- (2018) Heather L. Gray-Edwards et al. HUMAN GENE THERAPY
- Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease
- (2018) Nadia L. Mitchell et al. MOLECULAR THERAPY
- Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds
- (2018) Marina Naval-Sanchez et al. Nature Communications
- Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions
- (2018) Matthew Pelekanos et al. Theranostics
- Indices of comparative cognition: assessing animal models of human brain function
- (2018) Sebastian D. McBride et al. EXPERIMENTAL BRAIN RESEARCH
- Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)
- (2018) Laura Vilella et al. NEUROLOGY
- New Approaches to Tay-Sachs Disease Therapy
- (2018) Valeriya V. Solovyeva et al. Frontiers in Physiology
- A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments
- (2017) Jérôme Stirnemann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Imposed running exercise does not alter cell proliferation in the neurogenic niches of young lambs
- (2017) M. E. V. Swanson et al. JOURNAL OF ANIMAL SCIENCE
- Lipid composition of microdomains is altered in neuronopathic Gaucher disease sheep brain and spleen
- (2017) Leanne K. Hein et al. MOLECULAR GENETICS AND METABOLISM
- Alzheimer's disease markers in the aged sheep ( Ovis aries )
- (2017) Suzanne J. Reid et al. NEUROBIOLOGY OF AGING
- Relationships among neuroscore, magnetic resonance imaging features, and intracranial pressure in sheep affected by slow-growing brain lesions
- (2017) Maria A. Evangelisti et al. VETERINARY RADIOLOGY & ULTRASOUND
- Glucocerebrosidase Mutations in Parkinson Disease
- (2017) Grace O’Regan et al. Journal of Parkinsons Disease
- A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
- (2017) Emily L. Clark et al. PLoS Genetics
- Sheep recognize familiar and unfamiliar human faces from two-dimensional images
- (2017) Franziska Knolle et al. Royal Society Open Science
- Metabolic profiling of presymptomatic Huntington’s disease sheep reveals novel biomarkers
- (2017) Debra J. Skene et al. Scientific Reports
- Computation of a high-resolution MRI 3D stereotaxic atlas of the sheep brain
- (2016) Arsène Ella et al. JOURNAL OF COMPARATIVE NEUROLOGY
- An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep
- (2016) N. Perentos et al. JOURNAL OF NEUROSCIENCE
- An ovine model of spinal cord injury
- (2016) Saul Wilson et al. JOURNAL OF SPINAL CORD MEDICINE
- Glycosphingolipid analysis in a naturally occurring ovine model of acute neuronopathic Gaucher disease
- (2016) Litsa Karageorgos et al. NEUROBIOLOGY OF DISEASE
- The Prevalence of Huntington's Disease
- (2016) Michael D. Rawlins et al. NEUROEPIDEMIOLOGY
- Not Your Father's, or Mother's, Rodent: Moving Beyond B6
- (2016) Richard A. Miller NEURON
- Genetic Background Limits Generalizability of Genotype-Phenotype Relationships
- (2016) Laura J. Sittig et al. NEURON
- Automated detection and characterisation of rumination in sheep using in vivo electrophysiology
- (2016) Alister U. Nicol et al. PHYSIOLOGY & BEHAVIOR
- Metabolic disruption identified in the Huntington’s disease transgenic sheep model
- (2016) Renee. R. Handley et al. Scientific Reports
- Epidemiological characteristics of human prion diseases
- (2016) Cao Chen et al. Infectious Diseases of Poverty
- Kinematic analysis of the gait of adult sheep during treadmill locomotion: Parameter values, allowable total error, and potential for use in evaluating spinal cord injury
- (2015) Sina Safayi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Construction of an MRI 3D high resolution sheep brain template
- (2015) Arsène Ella et al. MAGNETIC RESONANCE IMAGING
- Gene Augmentation Therapy Restores Retinal Function and Visual Behavior in a Sheep Model of CNGA3 Achromatopsia
- (2015) Eyal Banin et al. MOLECULAR THERAPY
- Do I turn left or right? Effects of sex, age, experience and exit route on maze test performance in sheep
- (2015) Damien S. Hunter et al. PHYSIOLOGY & BEHAVIOR
- Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging
- (2015) Stephen J. Sawiak et al. PLoS One
- A stereotaxic, population-averaged T1w ovine brain atlas including cerebral morphology and tissue volumes
- (2015) Björn Nitzsche et al. Frontiers in Neuroanatomy
- Elevated Intracranial Pressure and Cerebral Edema following Permanent MCA Occlusion in an Ovine Model
- (2015) Adam J. Wells et al. PLoS One
- Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment
- (2014) A. J. Morton et al. HUMAN MOLECULAR GENETICS
- Characteristic CSF Prion Seeding Efficiency in Humans with Prion Diseases
- (2014) Maria Cramm et al. MOLECULAR NEUROBIOLOGY
- The Ovine Cerebral Venous System: Comparative Anatomy, Visualization, and Implications for Translational Research
- (2014) Anke Hoffmann et al. PLoS One
- The sheep genome illuminates biology of the rumen and lipid metabolism
- (2014) Y. Jiang et al. SCIENCE
- Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
- (2014) Timm Konold et al. Jove-Journal of Visualized Experiments
- Pathogenesis and therapies for infantile neuronal ceroid lipofuscinosis (infantile CLN1 disease)
- (2013) Jacqueline A. Hawkins-Salsbury et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- GM2 Gangliosidosis in British Jacob Sheep
- (2013) M.E. Wessels et al. JOURNAL OF COMPARATIVE PATHOLOGY
- Chronic Evaluation of a Clinical System for Deep Brain Stimulation and Recording of Neural Network Activity
- (2013) Paul H. Stypulkowski et al. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
- Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease
- (2012) Lynne I. McGuire et al. ANNALS OF NEUROLOGY
- Dynamics of olfactory and hippocampal neurogenesis in adult sheep
- (2012) M. Brus et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Further Investigations into the Speed of Cerebral Swelling Following Blunt Cranial Trauma*
- (2012) Roger W. Byard et al. JOURNAL OF FORENSIC SCIENCES
- A Surgical Model of Permanent and Transient Middle Cerebral Artery Stroke in the Sheep
- (2012) Adam J. Wells et al. PLoS One
- Clinical, electroretinographic and histomorphometric evaluation of the retina in sheep with natural scrapie
- (2011) Alain Regnier et al. BMC Veterinary Research
- Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses
- (2011) Maria Kousi et al. HUMAN MUTATION
- Executive Decision-Making in the Domestic Sheep
- (2011) A. Jennifer Morton et al. PLoS One
- Development of a Large Animal Model for Investigation of Deep Brain Stimulation for Epilepsy
- (2011) Paul H. Stypulkowski et al. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
- An ovine transgenic Huntington's disease model
- (2010) J. C. Jacobsen et al. HUMAN MOLECULAR GENETICS
- Gaucher disease in sheep
- (2010) Litsa Karageorgos et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Tay-Sachs disease in Jacob sheep
- (2010) Paola A. Torres et al. MOLECULAR GENETICS AND METABOLISM
- Pathology of GM2 Gangliosidosis in Jacob Sheep
- (2010) B. F. Porter et al. VETERINARY PATHOLOGY
- Immunohistochemical Characterisation of Classical Scrapie Neuropathology in Sheep
- (2009) E. Vidal et al. JOURNAL OF COMPARATIVE PATHOLOGY
- How rapidly does cerebral swelling follow trauma? Observations using an animal model and possible implications in infancy
- (2009) Roger W. Byard et al. Legal Medicine
- Human variant Creutzfeldt-Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein
- (2009) C. D. Orru et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain
- (2008) Sarah Jo Moore et al. ACTA NEUROPATHOLOGICA
- Prion diseases are efficiently transmitted by blood transfusion in sheep
- (2008) F. Houston et al. BLOOD
- Permanent Middle Cerebral Artery Occlusion in Sheep: A Novel Large Animal Model of Focal Cerebral Ischemia
- (2008) Johannes Boltze et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Phenotype, diagnosis, and treatment of Gaucher's disease
- (2008) Gregory A Grabowski LANCET
- A Murine Model of Infantile Neuronal Ceroid Lipofuscinosis—Ultrastructural Evaluation of Storage in the Central Nervous System and Viscera
- (2008) Nancy Galvin et al. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
- Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology
- (2008) Sylvie L. Benestad et al. VETERINARY RESEARCH
- TSE pathogenesis in cattle and sheep
- (2008) Lucien J.M. van Keulen et al. VETERINARY RESEARCH
- A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>>>A) leading to excision of exon 3
- (2007) Tony Frugier et al. NEUROBIOLOGY OF DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation