Availability and Metabolic Fate of Olive Phenolic Alcohols Hydroxytyrosol and Tyrosol in the Human GI Tract Simulated by the In Vitro GIDM–Colon Model

In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review

(2021) Arianna Fedi et al.   JOURNAL OF CONTROLLED RELEASE

Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

(2021) Francesca Annunziata et al.   Antioxidants

Conjugated Metabolites of Hydroxytyrosol and Tyrosol Contribute to the Maintenance of Nitric Oxide Balance in Human Aortic Endothelial Cells at Physiologically Relevant Concentrations

(2021) Gabriele Serreli et al.   MOLECULES

Application of Advanced Technologies in Natural Product Research: A re-view with special emphasis on ADMET profiling

(2020) Pobitra Borah et al.   CURRENT DRUG METABOLISM

Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans

(2020) Carolina Alemán-Jiménez et al.   EUROPEAN JOURNAL OF NUTRITION

Simulated Gastrointestinal Biotransformation of Chlorogenic Acid, Flavonoids, Flavonolignans and Triterpenoid Saponins in Cecropia obtusifolia Leaf Extract

(2020) Andrés Rivera-Mondragón et al.   PLANTA MEDICA

Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases

(2020) Chiara D’Angelo et al.   Cells

Oxidative polymerization process of hydroxytyrosol catalysed by polyphenol oxidases or peroxidase: Characterization, kinetics and thermodynamics

(2020) Pujun Xie et al.   FOOD CHEMISTRY

Health benefits of olive oil and its components: Impact on gut microbiota, and prevention of the risk of development of noncommunicable diseases

(2019) Mohsen Gavahian et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

(2019) Karković Marković et al.   MOLECULES

Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints

(2019) Rikard Landberg et al.   EUROPEAN JOURNAL OF NUTRITION

Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial

(2019) Anna Boronat et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polymeric bile acid sequestrants: Review of design, in vitro binding activities, and hypocholesterolemic effects

(2018) Eva Heřmánková et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

(2018) María Robles-Almazan et al.   FOOD RESEARCH INTERNATIONAL

In vitro gastrointestinal biotransformation and characterization of a Desmodium adscendens decoction: the first step in unravelling its behaviour in the human body

(2018) Ines van Dooren et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells

(2018) María-Carmen López de las Hazas et al.   Journal of Functional Foods

CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol

(2017) Jose Rodríguez-Morató et al.   FOOD CHEMISTRY

Hydroxytyrosol and the Colonic Metabolites Derived from Virgin Olive Oil Intake Induce Cell Cycle Arrest and Apoptosis in Colon Cancer Cells

(2017) Maria-Carmen López de las Hazas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vitro and In Vivo Study of the Gastrointestinal Absorption and Metabolisation of Hymenocardine, a Cyclopeptide Alkaloid

(2017) Emmy Tuenter et al.   PLANTA MEDICA

Chemical transformation of xenobiotics by the human gut microbiota

(2017) Nitzan Koppel et al.   SCIENCE

Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?

(2017) Carmela Santangelo et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol

(2016) Jose Rodríguez-Morató et al.   DRUG METABOLISM REVIEWS

Antioxidant activity of olive phenols and other dietary phenols in model gastric conditions: Scavenging of the free radical DPPH and inhibition of the haem-induced peroxidation of linoleic acid

(2016) Sabiha Achat et al.   FOOD CHEMISTRY

Pharmacokinetics of Tyrosol Metabolites in Rats

(2016) Da-Hye Lee et al.   MOLECULES

Therapeutic targeting of bile acids

(2015) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

(2015) Sandrina A. Heleno et al.   FOOD CHEMISTRY

Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review

(2015) Juana Mosele et al.   MOLECULES

Development and Validation of an in vitro Experimental GastroIntestinal Dialysis Model with Colon Phase to Study the Availability and Colonic Metabolisation of Polyphenolic Compounds

(2015) Annelies Breynaert et al.   PLANTA MEDICA

Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches

(2014) Juana I. Mosele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

In Silico ADMET Prediction: Recent Advances, Current Challenges and Future Trends

(2013) Feixiong Cheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats

(2013) Aristotelis Kotronoulas et al.   PHARMACOLOGICAL RESEARCH

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

(2012) Maarit J. Rein et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A new hydroxytyrosol metabolite identified in human plasma: Hydroxytyrosol acetate sulphate

(2012) Laura Rubió et al.   FOOD CHEMISTRY

Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers

(2012) Gema Pereira-Caro et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Pharmacokinetics of Natural Compounds

(2012) H Derendorf   PLANTA MEDICA

In Silico Prediction of Cytochrome P450-Mediated Drug Metabolism

(2011) Tao Zhang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

The intestinal microbiome: A separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals

(2010) Sam Possemiers et al.   FITOTERAPIA

Direct analysis of glucuronidated metabolites of main olive oil phenols in human urine after dietary consumption of virgin olive oil

(2010) Olha Khymenets et al.   FOOD CHEMISTRY

Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins

(2010) Maria González-Santiago et al.   PHARMACOLOGICAL RESEARCH

Enzymatic Esterification in Aqueous Miniemulsions

(2009) Eugen M. Aschenbrenner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography–tandem mass spectrometry

(2009) Manuel Suárez et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract

(2009) G Corona et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Bioavailability of olive oil phenolic compounds in humans

(2008) R. de la Torre   INFLAMMOPHARMACOLOGY

Pharmacokinetics in Drug Discovery

(2007) Ana Ruiz-Garcia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES