Biofilm Survival Strategies in Chronic Wounds

Bacterial biofilms predominate in both acute and chronic human lung infections

(2022) Mette Kolpen et al.   THORAX

Sampling challenges in diagnosis of chronic bacterial infections

(2021) Tim Holm Jakobsen et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A multiomics approach to identify host-microbe alterations associated with infection severity in diabetic foot infections: a pilot study

(2021) Michael Radzieta et al.   npj Biofilms and Microbiomes

The importance of understanding the infectious microenvironment

(2021) Thomas Bjarnsholt et al.   LANCET INFECTIOUS DISEASES

Quantitative Framework for Model Evaluation in Microbiology Research Using Pseudomonas aeruginosa and Cystic Fibrosis Infection as a Test Case

(2020) Daniel M. Cornforth et al.   mBio

Role of pH Value in Clinically Relevant Diagnosis

(2020) Shu-Hua Kuo et al.   Diagnostics

The pig as a model for immunology research

(2020) Reinhard Pabst   CELL AND TISSUE RESEARCH

The origin of extracellular DNA in bacterial biofilm infections in vivo

(2020) Maria Alhede et al.   Pathogens and Disease

Prokaryotic single-cell RNA sequencing by in situ combinatorial indexing

(2020) Sydney B. Blattman et al.   Nature Microbiology

The zone model: A conceptual model for understanding the microenvironment of chronic wound infection

(2020) Klaus Kirketerp‐Møller et al.   WOUND REPAIR AND REGENERATION

Metatranscriptomic Analysis Reveals Active Bacterial Communities in Diabetic Foot Infections

(2020) Fatemah Sadeghpour Heravi et al.   Frontiers in Microbiology

Current In Vitro Biofilm-Infected Chronic Wound Models for Developing New Treatment Possibilities

(2020) Ida C. Thaarup et al.   Advances in Wound Care

The extracellular polysaccharide matrix of Pseudomonas aeruginosa biofilms is a determinant of polymorphonuclear leukocyte responses

(2020) Morten Rybtke et al.   INFECTION AND IMMUNITY

Single-cell RNA-sequencing reports growth-condition-specific global transcriptomes of individual bacteria

(2020) Fabian Imdahl et al.   Nature Microbiology

Human Wounds and Its Burden: An Updated Compendium of Estimates

(2019) Chandan K. Sen   Advances in Wound Care

Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth,not virulence or biofilm functions

(2019) Sarah J. Morgan et al.   PLoS Pathogens

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

(2019) Oana Ciofu et al.   Frontiers in Microbiology

Conceptual Model of Biofilm Antibiotic Tolerance that Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology

(2019) Philip S. Stewart et al.   JOURNAL OF BACTERIOLOGY

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

(2019) Allison J. Lopatkin et al.   Nature Microbiology

Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

(2019) Mette Kolpen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Device to Predict Short-Term Healing Outcome of Chronic Wounds

(2019) Hong Vu et al.   Advances in Wound Care

Need for Improved Definition of ”Chronic Wounds” in Clinical Studies

(2018) B Kyaw et al.   ACTA DERMATO-VENEREOLOGICA

Understanding the microbiome of diabetic foot osteomyelitis: insights from molecular and microscopic approaches

(2018) K. Johani et al.   CLINICAL MICROBIOLOGY AND INFECTION

Development of a mixed-species biofilm model and its virulence implications in device related infections

(2018) Naing T. Thet et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Spatial determinants of quorum signaling in aPseudomonas aeruginosainfection model

(2018) Sophie E. Darch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosatranscriptome during human infection

(2018) Daniel M. Cornforth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies

(2018) Laura Martinengo et al.   ANNALS OF EPIDEMIOLOGY

Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo

(2017) M. Malone et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The physical boundaries of public goods cooperation between surface-attached bacterial cells

(2017) Michael Weigert et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers

(2017) Khalid Johani et al.   International Wound Journal

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

(2017) Ashraful Haque et al.   Genome Medicine

The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

(2017) M. Malone et al.   Journal of Wound Care

Gel-Entrapped Staphylococcus aureus Bacteria as Models of Biofilm Infection Exhibit Growth in Dense Aggregates, Oxygen Limitation, Antibiotic Tolerance, and Heterogeneous Gene Expression

(2016) Breana Pabst et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vivo gene expression in a Staphylococcus aureus prosthetic joint infection characterized by RNA sequencing and metabolomics: a pilot study

(2016) Yijuan Xu et al.   BMC MICROBIOLOGY

A post-planktonic era of in vitro infectious models: issues and changes addressed by a clinically relevant wound like media

(2016) Urvish Trivedi et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Dynamic cell–matrix interactions modulate microbial biofilm and tissue 3D microenvironments

(2016) Hyun Koo et al.   CURRENT OPINION IN CELL BIOLOGY

Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds

(2016) Garth A. James et al.   WOUND REPAIR AND REGENERATION

The immunology of the porcine skin and its value as a model for human skin

(2015) Artur Summerfield et al.   MOLECULAR IMMUNOLOGY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

pH Influence on Antibacterial Efficacy of Common Antiseptic Substances

(2015) Cornelia Wiegand et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

The Effect of pH on the Extracellular Matrix and Biofilms

(2015) Eleri M. Jones et al.   Advances in Wound Care

Challenges in the Treatment of Chronic Wounds

(2015) Robert G. Frykberg et al.   Advances in Wound Care

Extracellular DNA Impedes the Transport of Vancomycin in Staphylococcus epidermidis Biofilms Preexposed to Subinhibitory Concentrations of Vancomycin

(2014) Natalya Doroshenko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiseptics for treating infected wounds: Efficacy on biofilms and effect of pH

(2014) Steven L. Percival et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity

(2014) Robert Nunan et al.   Disease Models & Mechanisms

The importance of the viable but non-culturable state in human bacterial pathogens

(2014) Laam Li et al.   Frontiers in Microbiology

The Visualization of Biofilms in Chronic Diabetic Foot Wounds Using Routine Diagnostic Microscopy Methods

(2014) Angela Oates et al.   Journal of Diabetes Research

Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms

(2013) Wen-Chi Chiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection

(2013) Irena Pastar et al.   PLoS One

Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1

(2013) A. L. DuMont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The in vivo biofilm

(2013) Thomas Bjarnsholt et al.   TRENDS IN MICROBIOLOGY

Detection of viable but non-culturable staphylococci in biofilms from central venous catheters negative on standard microbiological assays

(2012) G. Zandri et al.   CLINICAL MICROBIOLOGY AND INFECTION

Comparison of Culture and Molecular Identification of Bacteria in Chronic Wounds

(2012) Daniel D. Rhoads et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of Pseudomonas aeruginosa Biofilm–Infected Wounds with Clinical Wound Care Strategies

(2012) Akhil K. Seth et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Oxygen: Implications for Wound Healing

(2012) Diego M. Castilla et al.   Advances in Wound Care

Clinically Addressing Biofilm in Chronic Wounds

(2012) Christopher Attinger et al.   Advances in Wound Care

Biofilms in chronic diabetic foot ulcers—a study of 2 cases

(2011) Daniëlle Neut et al.   Acta Orthopaedica

An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions

(2011) Trevor Dalton et al.   PLoS One

Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

(2011) Mustafa Fazli et al.   WOUND REPAIR AND REGENERATION

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis

(2010) James P Folsom et al.   BMC MICROBIOLOGY

Temperature and pH affect the production of bacterial biofilm

(2010) A. Hoštacká et al.   FOLIA MICROBIOLOGICA

Macroscale spatial variation in chronic wound microbiota: A cross-sectional study

(2010) Lance B. Price et al.   WOUND REPAIR AND REGENERATION

The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods

(2010) Trine R. Thomsen et al.   WOUND REPAIR AND REGENERATION

Nonrandom Distribution of Pseudomonas aeruginosa and Staphylococcus aureus in Chronic Wounds

(2009) M. Fazli et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH)

(2009) S. Malic et al.   MICROBIOLOGY-SGM

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

(2009) M Kolpen et al.   THORAX

Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model

(2009) Clark F. Schierle et al.   WOUND REPAIR AND REGENERATION

Hyperbaric Oxygen Therapy for Wound Healing and Limb Salvage: A Systematic Review

(2009) Robert J. Goldman   PM&R

Distribution, Organization, and Ecology of Bacteria in Chronic Wounds

(2008) K. Kirketerp-Moller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Physiological heterogeneity in biofilms

(2008) Philip S. Stewart et al.   NATURE REVIEWS MICROBIOLOGY

Biofilms in chronic wounds

(2008) Garth A. James et al.   WOUND REPAIR AND REGENERATION

Why chronic wounds will not heal: a novel hypothesis

(2007) Thomas Bjarnsholt et al.   WOUND REPAIR AND REGENERATION