Gut microbiome in non-alcoholic fatty liver disease associated hepatocellular carcinoma: Current knowledge and potential for therapeutics

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Gut microbiome in HCC – Mechanisms, diagnosis and therapy

(2020) Robert F. Schwabe et al.   JOURNAL OF HEPATOLOGY

Diet and liver cancer risk: a narrative review of epidemiological evidence

(2020) Wan-Shui Yang et al.   BRITISH JOURNAL OF NUTRITION

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

(2020) Vishal Singh et al.   Gut Microbes

Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review

(2020) Yi-Hsun Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy

(2020) Giulia Longhi et al.   Frontiers in Microbiology

The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer

(2020) Chunye Zhang et al.   Frontiers in Oncology

Gut Microbiota and Cancer: From Pathogenesis to Therapy

(2019) Silvia Vivarelli et al.   Cancers

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma

(2019) Yi Zheng et al.   Journal for ImmunoTherapy of Cancer

New insights and therapeutic implication of gut microbiota in non-alcoholic fatty liver disease and its associated liver cancer

(2019) Niama Ezzaidi et al.   CANCER LETTERS

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice

(2019) Qi Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial

(2018) Marc R. Bomhof et al.   EUROPEAN JOURNAL OF NUTRITION

Bile Acid Metabolism in Liver Pathobiology

(2018) John Y. L. Chiang et al.   GENE EXPRESSION

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

(2018) Shoji Yamada et al.   Oncotarget

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

(2018) Zhigang Ren et al.   GUT

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

(2017) Aafke W. F. Janssen et al.   JOURNAL OF LIPID RESEARCH

The gut microbiome and liver cancer: mechanisms and clinical translation

(2017) Le-Xing Yu et al.   Nature Reviews Gastroenterology & Hepatology

Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model

(2017) JianHua Han et al.   Obesity

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

(2017) Nader N. Massarweh et al.   Cancer Control

Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma

(2017) Jee San Lee et al.   PLoS One

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030

(2016) Jessica L. Petrick et al.   JOURNAL OF CLINICAL ONCOLOGY

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Profile of Gut Microbiota Associated With the Presence of Hepatocellular Cancer in Patients With Liver Cirrhosis

(2016) M. Grąt et al.   TRANSPLANTATION PROCEEDINGS

Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet

(2016) Douglas Mahana et al.   Genome Medicine

TLR4-Dependent Secretion by Hepatic Stellate Cells of the Neutrophil-Chemoattractant CXCL1 Mediates Liver Response to Gut Microbiota

(2016) Amélie E. Bigorgne et al.   PLoS One

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

EGFR Signaling in Liver Diseases

(2015) Karin Komposch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Intestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature

(2013) Kirsten E. Pijls et al.   LIVER INTERNATIONAL

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

The role of the immune system in governing host-microbe interactions in the intestine

(2013) Eric M Brown et al.   NATURE IMMUNOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

(2011) Reiner Jumpertz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis

(2010) Pablo Bellot et al.   HEPATOLOGY

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL