Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with 89Zr Radioisotope in Mice and Rats

Therapeutically harnessing extracellular vesicles

(2022) Lesley Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

(2021) Elisa Lázaro-Ibáñez et al.   ACS Nano

Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models

(2021) Samantha Sheller-Miller et al.   Science Advances

Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

(2021) Amin Mirzaaghasi et al.   Pharmaceutics

Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury

(2021) Seonghun Kim et al.   KIDNEY INTERNATIONAL

Extracellular vesicles as a next-generation drug delivery platform

(2021) Inge Katrin Herrmann et al.   Nature Nanotechnology

Biodistribution of extracellular vesicles following administration into animals: A systematic review

(2021) Matthew Kang et al.   Journal of Extracellular Vesicles

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

(2020) Yong Weon Yi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Radioactive Labeling of Milk-Derived Exosomes with 99mTc and In Vivo Tracking by SPECT Imaging

(2020) María Isabel González et al.   Nanomaterials

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

(2020) Hojun Choi et al.   Science Advances

Current Perspectives on 89Zr-PET Imaging

(2020) Joon-Kee Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next

(2020) Yonghee Song et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Identification of Lymphatic and Hematogenous Routes of Rapidly Labeled Radioactive and Fluorescent Exosomes through Highly Sensitive Multimodal Imaging

(2020) Kyung Oh Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

(2020) Yi Zhang et al.   International Journal of Nanomedicine

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

(2020) Shubham Salunkhe et al.   JOURNAL OF CONTROLLED RELEASE

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

Dexosomes as a cell-free vaccine for cancer immunotherapy

(2020) Sepideh Nikfarjam et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Cre-Reporter Mouse Model to Determine Exosome Communication and Function during Pregnancy

(2019) Samantha Sheller-Miller et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Differential in vivo biodistribution of 131I-labeled exosomes from diverse cellular origins and its implication for theranostic application

(2019) Mohammad H. Rashid et al.   Nanomedicine-Nanotechnology Biology and Medicine

Recent advancements in the use of exosomes as drug delivery systems

(2018) Edwin J. Bunggulawa et al.   JOURNAL OF NANOBIOTECHNOLOGY

Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury

(2018) Dong Li et al.   Frontiers in Neuroscience

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

(2017) Akihiro Matsumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics of Exosomes—An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

(2017) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

(2017) Prakash Gangadaran et al.   Biomed Research International

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

(2016) Sylwia Koniusz et al.   Frontiers in Cellular Neuroscience

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

(2015) Do Won Hwang et al.   Scientific Reports

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies

(2015) Brian M. Zeglis et al.   Jove-Journal of Visualized Experiments

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

(2014) CRISTINA GRANGE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges

(2013) Gabriel Fischer et al.   MOLECULES

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

In vivo biodistribution and accumulation of 89Zr in mice

(2011) Diane S. Abou et al.   NUCLEAR MEDICINE AND BIOLOGY

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Exosomes from human saliva as a source of microRNA biomarkers

(2009) A Michael et al.   ORAL DISEASES