GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

(2021) Xiang Luo et al.   CELL DEATH AND DIFFERENTIATION

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

(2021) Sehwan Jang et al.   Redox Biology

Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis

(2021) Luyang Xiong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Incidence and prevalence of amyotrophic lateral sclerosis in urban China: a national population-based study

(2020) Lu Xu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disease-modifying therapies in amyotrophic lateral sclerosis

(2020) Adriano Chiò et al.   NEUROPHARMACOLOGY

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

(2020) Min Wang et al.   Cell Death & Disease

Molecular and Cellular Mechanisms Affected in ALS

(2020) Laura Le Gall et al.   Journal of Personalized Medicine

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Assessing aberrant muscle activity patterns via the analysis of surface EMG data collected during a functional evaluation

(2019) Fatemeh Noushin Golabchi et al.   BMC MUSCULOSKELETAL DISORDERS

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Edaravone for the treatment of amyotrophic lateral sclerosis

(2019) Hiide Yoshino   Expert Review of Neurotherapeutics

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis

(2019) Natalia Nowicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

Radicava (edaravone) for amyotrophic lateral sclerosis: US experience at 1 year after launch

(2019) Carlayne Jackson et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Enhanced Neural Regeneration with a Concomitant Treatment of Framework Nucleic Acid and Stem Cells in Spinal Cord Injury

(2019) Wenjuan Ma et al.   ACS Applied Materials & Interfaces

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice

(2018) Rodolfo G. Gatto et al.   BRAIN RESEARCH

Amyotrophic Lateral Sclerosis: An Update for 2018

(2018) Björn Oskarsson et al.   MAYO CLINIC PROCEEDINGS

Intrathecal Injection of scAAV9–hIGF1 Prolongs the Survival of ALS Model Mice by Inhibiting the NF-kB Pathway

(2018) HaoJie Hu et al.   NEUROSCIENCE

Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology

(2018) Mukesh Gautam et al.   ACTA NEUROPATHOLOGICA

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease

(2017) Dhaval Patel et al.   Oxidative Medicine and Cellular Longevity

Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers

(2016) Fabiola Puentes et al.   BRAIN PATHOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040

(2016) Karissa C. Arthur et al.   Nature Communications

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Controversies and priorities in amyotrophic lateral sclerosis

(2013) Martin R Turner et al.   LANCET NEUROLOGY

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

(2013) K. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

(2011) Frederick P Bellinger et al.   Molecular Neurodegeneration

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking

(2009) Johannes Hirrlinger et al.   BRAIN RESEARCH REVIEWS

Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development

(2008) C. Ufer et al.   GENES & DEVELOPMENT