Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer’s Disease

An AI‐based Prediction Model for Drug‐drug Interactions in Osteoporosis and Paget's Diseases from SMILES

(2022) Truong Nguyen Khanh Hung et al.   Molecular Informatics

Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer’s disease

(2021) Ray O. Bahado-Singh et al.   PLoS One

Integrated Analysis of Whole Genome and Epigenome Data Using Machine Learning Technology: Toward the Establishment of Precision Oncology

(2021) Ken Asada et al.   Frontiers in Oncology

A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer’s disease

(2021) Yanting Huang et al.   Nature Communications

Epigenetics Is Implicated in the Basis of Gender Incongruence: An Epigenome-Wide Association Analysis

(2021) Karla Ramirez et al.   Frontiers in Neuroscience

The Role of Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases

(2021) Chen Yang et al.   Frontiers in Molecular Biosciences

A deep learning framework with an embedded-based feature selection approach for the early detection of the Alzheimer's disease

(2021) Nivedhitha Mahendran et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Improved Prediction Model of Protein Lysine Crotonylation Sites Using Bidirectional Recurrent Neural Networks

(2021) Sian Soo Tng et al.   JOURNAL OF PROTEOME RESEARCH

Association and Gene–Gene Interactions Study of Late-Onset Alzheimer’s Disease in the Russian Population

(2021) Anna Bocharova et al.   Genes

Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data

(2021) Ziyi Li et al.   Emerging Topics in Life Sciences

Disruption of a RAC1-centred network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration

(2020) Masataka Kikuchi et al.   HUMAN MOLECULAR GENETICS

Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2020) Zhike Zhou et al.   Frontiers in Aging Neuroscience

Identification of Methylated Gene Biomarkers in Patients with Alzheimer’s Disease Based on Machine Learning

(2020) Jianting Ren et al.   Biomed Research International

Alzheimer’s Disease: What Can We Learn From the Peripheral Olfactory System?

(2020) Michele Dibattista et al.   Frontiers in Neuroscience

The Role of the SLC Transporters Protein in the Neurodegenerative Disorders

(2020) Asli Ayka et al.   Clinical Psychopharmacology and Neuroscience

Cardiac-specific methylation patterns of circulating DNA for identification of cardiomyocyte death

(2020) Qin Liu et al.   BMC Cardiovascular Disorders

Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage

(2020) Grant C. O’Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Donor-Derived Cell-Free DNA for Assessment of Allograft Injury in Kidney Transplant Recipients During the Time of the Coronavirus Disease 2019 Pandemic

(2020) Neetika Garg et al.   TRANSPLANTATION PROCEEDINGS

Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through RNA sequencing analysis

(2020) Daichi Shigemizu et al.   Alzheimers Research & Therapy

Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

(2020) Jonas B. Nielsen et al.   Nature Communications

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology

(2019) Harald Hampel et al.   Frontiers in Pharmacology

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological

(2019) Aaradhita Upadhyay et al.   Frontiers in Molecular Neuroscience

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

(2019) Georgina Mansell et al.   BMC GENOMICS

Life and death of circulating cell-free DNA

(2019) Anatoli Kustanovich et al.   CANCER BIOLOGY & THERAPY

Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy

(2019) Ray O. Bahado-Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Epigenetic Modifications in Alzheimer’s Neuropathology and Therapeutics

(2019) Michelle Esposito et al.   Frontiers in Neuroscience

DNA hypermethylation in disease: mechanisms and clinical relevance

(2019) Melanie Ehrlich   Epigenetics

Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction

(2019) Ray Oliver Bahado-Singh et al.   PLoS One

Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data

(2019) Taeho Jo et al.   Frontiers in Aging Neuroscience

Artificial Intelligence and the detection of pediatric concussion using epigenomic analysis

(2019) Ray O. Bahado-Singh et al.   BRAIN RESEARCH

Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ 1–42 , total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40

(2018) Harald Hampel et al.   Alzheimers & Dementia

Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis

(2018) Amogha Tadimety et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis

(2018) S. Akila Parvathy Dharshini et al.   GENOMICS

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

(2018) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High glucose upregulates myosin light chain kinase to induce microfilament cytoskeleton rearrangement in hippocampal neurons

(2018) Liying Zhu et al.   Molecular Medicine Reports

The Role of Methylated Circulating Nucleic Acids as a Potential Biomarker in Alzheimer’s Disease

(2018) Ming-Chyi Pai et al.   MOLECULAR NEUROBIOLOGY

Blood Collection and Cell-Free DNA Isolation Methods Influence the Sensitivity of Liquid Biopsy Analysis for Colorectal Cancer Detection

(2018) Barbara Kinga Barták et al.   PATHOLOGY & ONCOLOGY RESEARCH

Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF-β1 Signaling Pathway

(2018) Yalei Jin et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review)

(2018) Alessia Finotti et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sharing Pathogenetic Mechanisms between Acute Myocardial Infarction and Alzheimer's Disease as Shown by Partially Overlapping of Gene Variant Profiles

(2018) Federico Licastro et al.   JOURNAL OF ALZHEIMERS DISEASE

Donor-specific Cell-Free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review

(2018) Simon R. Knight et al.   TRANSPLANTATION

Artificial Intelligence and amniotic fluid multiomics analysis: The prediction of perinatal outcome in asymptomatic short cervix

(2018) Ray O. Bahado-Singh et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

(2018) Joshua Moss et al.   Nature Communications

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data

(2017) Fadhl M. Alakwaa et al.   JOURNAL OF PROTEOME RESEARCH

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

(2017) Kira S. Sheinerman et al.   Alzheimers Research & Therapy

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

(2016) Timothy Hardy et al.   GUT

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1

(2016) Julie Borgel et al.   NUCLEIC ACIDS RESEARCH

Altered protein phosphorylation as a resource for potential AD biomarkers

(2016) Ana Gabriela Henriques et al.   Scientific Reports

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

(2016) Yanfang Li et al.   Frontiers in Aging Neuroscience

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

(2015) Eilis Hannon et al.   Epigenetics

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

(2015) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Calcium/calmodulin-dependent kinase II and Alzheimer’s disease

(2015) Anshua Ghosh et al.   Molecular Brain

Circulating biomarkers that predict incident dementia

(2014) Galit Weinstein et al.   Alzheimers Research & Therapy

Using random forest to classify T-cell epitopes based on amino acid properties and molecular features

(2013) Jian-Hua Huang et al.   ANALYTICA CHIMICA ACTA

Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography

(2013) Mary Ellen I. Koran et al.   HUMAN GENETICS

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Axon guidance effect of classical morphogens Shh and BMP7 in the hypothalamo-pituitary system

(2013) Fang Liu et al.   NEUROSCIENCE LETTERS

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Multivariate methods in metabolomics – from pre-processing to dimension reduction and statistical analysis

(2011) Kristian Hovde Liland   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Calcium Signalling and Alzheimer’s Disease

(2010) Michael J. Berridge   NEUROCHEMICAL RESEARCH

Analysis of Metabolomic Data Using Support Vector Machines

(2008) Sankar Mahadevan et al.   ANALYTICAL CHEMISTRY