Regulation of Dynamic Cell Adhesion by Integrin-Integrin Crosstalk

New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain

(2022) Ralph T Böttcher et al.   Life Science Alliance

Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

(2021) Johanna Kliche et al.   Science Signaling

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

(2021) Bálint Mészáros et al.   Science Signaling

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

(2021) Eun Jeong Park et al.   Viruses-Basel

Phosphorylation of Kindlins and the Control of Integrin Function

(2021) Katarzyna Bialkowska et al.   Cells

Integrin cross-talk modulates stiffness-independent motility of CD4+ T lymphocytes

(2021) Sarah Hyun Ji Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Integrin activation is an essential component of SARS-CoV-2 infection

(2021) Peter Simons et al.   Scientific Reports

How integrin phosphorylations regulate cell adhesion and signaling

(2021) Carl G. Gahmberg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration

(2020) Ivo van der Bijl et al.   MATRIX BIOLOGY

The integrin linked kinase is required for chemokine-triggered high affinity conformation of neutrophil β2-integrin LFA1

(2020) Andreas Margraf et al.   BLOOD

Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates

(2020) Ivana Samaržija et al.   Cancers

LFA-1 signals to promote actin polymerization and upstream migration in T cells

(2020) Nathan H. Roy et al.   JOURNAL OF CELL SCIENCE

High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis

(2019) Zhichao Fan et al.   Cell Reports

VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1

(2019) Oisun Jung et al.   JOURNAL OF CELL SCIENCE

A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes

(2019) Alexander Hornung et al.   BIOPHYSICAL JOURNAL

Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion

(2018) Farhana Jahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

(2017) Mitasha Bharadwaj et al.   Nature Communications

LFA-1 integrin antibodies inhibit leukocyte  4 1-mediated adhesion by intracellular signaling

(2016) M. Gronholm et al.   BLOOD

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

(2016) Zhichao Fan et al.   Nature Communications

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model

(2016) Jiansong Huang et al.   Frontiers of Medicine

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

(2015) S. Klapproth et al.   BLOOD

The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged

(2015) George A. Dominguez et al.   Integrative Biology

Site-specific Phosphorylation of Kindlin-3 Protein Regulates Its Capacity to Control Cellular Responses Mediated by Integrin αIIbβ3

(2015) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Phosphorylations Transmit Signals from Leukocyte β2to β1Integrins and Regulate Adhesion

(2014) Liisa M. Uotila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Serine/Threonine Kinase Ndr2 Controls Integrin Trafficking and Integrin-Dependent Neurite Growth

(2014) K. Rehberg et al.   JOURNAL OF NEUROSCIENCE

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of talin-dependent integrin signaling and crosstalk

(2013) Mitali Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

T Lymphocytes Orient against the Direction of Fluid Flow during LFA-1-Mediated Migration

(2013) Marie-Pierre Valignat et al.   BIOPHYSICAL JOURNAL

Integrin CD11c/CD18 α-Chain Phosphorylation Is Functionally Important

(2013) Liisa M. Uotila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β

(2013) Jenny G. Parvani et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1

(2011) M. Gronholm et al.   JOURNAL OF IMMUNOLOGY

p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration

(2010) Zhilun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation

(2010) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Transdominant regulation of integrin function: Mechanisms of crosstalk

(2009) Annette M. Gonzalez et al.   CELLULAR SIGNALLING

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD

Localized α4 Integrin Phosphorylation Directs Shear Stress–Induced Endothelial Cell Alignment

(2008) Lawrence E. Goldfinger et al.   CIRCULATION RESEARCH

Integrin Cross-talk in Endothelial Cells Is Regulated by Protein Kinase A and Protein Phosphatase 1

(2008) Annette M. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY