The Role of Osteocytes in Age-Related Bone Loss

Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone

(2015) Marilina Piemontese et al.   BONE

Role of cortical bone in bone fragility

(2015) Yohann Bala et al.   CURRENT OPINION IN RHEUMATOLOGY

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

(2015) Cheng-Feng Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

(2015) Keiji Kobayashi et al.   Scientific Reports

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

(2014) Marie Nollet et al.   Autophagy

Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population

(2014) Ke Chen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Periosteal PTHrP regulates cortical bone modeling during linear growth in mice

(2014) Meina Wang et al.   JOURNAL OF ANATOMY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Osteocytic Canalicular Networks: Morphological Implications for Altered Mechanosensitivity

(2013) Petar Milovanovic et al.   ACS Nano

Aged Male Rats Regenerate Cortical Bone with Reduced Osteocyte Density and Reduced Secretion of Nitric Oxide After Mechanical Stimulation

(2013) Danese M. Joiner et al.   CALCIFIED TISSUE INTERNATIONAL

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH

(2013) Vaibhav Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation

(2013) Fei Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dysapoptosis of Osteoblasts and Osteocytes Increases Cancellous Bone Formation But Exaggerates Cortical Porosity With Age

(2013) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tissue-Level Mechanisms Responsible for the Increase in Bone Formation and Bone Volume by Sclerostin Antibody

(2013) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Femoral osteocyte lacunar density, volume and morphology in women across the lifespan

(2013) Yasmin Carter et al.   JOURNAL OF STRUCTURAL BIOLOGY

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities

(2012) Valerie Vanhooren et al.   AGEING RESEARCH REVIEWS

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

(2012) Oran D. Kennedy et al.   BONE

Osteocyte apoptosis

(2012) Robert L. Jilka et al.   BONE

Osteocyte Apoptosis and Absence of Bone Remodeling in Human Auditory Ossicles and Scleral Ossicles of Lower Vertebrates: A Mere Coincidence or Linked Processes?

(2012) Carla Palumbo et al.   CALCIFIED TISSUE INTERNATIONAL

Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases

(2012) Hua Zhu Ke et al.   ENDOCRINE REVIEWS

Glucocorticoid-Induced Osteoporosis and Osteonecrosis

(2012) Robert S. Weinstein   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation

(2012) Hai Qing et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

Pathogenesis of Age-Related Bone Loss in Humans

(2012) S. Khosla   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation

(2012) Ronald Y. Kwon et al.   PLoS One

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

(2011) Zhousheng Xiao et al.   FASEB JOURNAL

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

(2011) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship of age to bone microstructure independent of areal bone mineral density

(2011) Kristy M Nicks et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

(2011) William F Powell et al.   JOURNAL OF ENDOCRINOLOGY

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The RANKL Distal Control Region Is Required for the Increase in RANKL Expression, But Not the Bone Loss, Associated with Hyperparathyroidism or Lactation in Adult Mice

(2011) Melda Onal et al.   MOLECULAR ENDOCRINOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone

(2010) Björn Busse et al.   AGING CELL

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms

(2010) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of ethnicity and age or menopause on the structure and geometry of iliac bone

(2010) Z.-H. Han et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Glucocorticoid-induced autophagy in osteocytes

(2010) Xuechun Xia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Structure and remodelling of the human parietal bone: An age and gender histomorphometric study

(2010) Daniel Torres-Lagares et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation

(2010) Emily G Farrow et al.   JOURNAL OF ENDOCRINOLOGY

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study

(2010) Roger MD Zebaze et al.   LANCET

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Simultaneous 3D visualization and quantification of murine bone and bone vasculature using micro-computed tomography and vascular replica

(2009) Philipp Schneider et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

(2007) Lidan You et al.   BONE

Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass

(2007) Carlo Galli et al.   ENDOCRINOLOGY

Is HMGB1 an osteocyte alarmin?

(2007) Joseph P. Bidwell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY