CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

(2021) James H. Felce et al.   Frontiers in Cell and Developmental Biology

CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

(2021) Rosanna Mezzapelle et al.   EMBO Molecular Medicine

HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis

(2021) Lorenzo Spagnuolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

(2020) Bryan S. Stephens et al.   Science Signaling

The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration

(2020) Marco E. Bianchi et al.   Frontiers in Immunology

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer

(2020) Yi Shi et al.   Frontiers in Pharmacology

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

(2019) Yan Gu et al.   NATURE MEDICINE

CXCR4, but not CXCR3, drives CD8+ T-cell entry into and migration through the murine bone marrow

(2019) Marieke Goedhart et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

(2019) Joyce Koenen et al.   MOLECULAR PHARMACOLOGY

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding

(2019) Martin Gustavsson et al.   Science Signaling

Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing

(2019) Saria Mcheik et al.   Frontiers in Immunology

Membrane lipid environment: Potential modulation of chemokine receptor function

(2018) Marcus Thelen et al.   CYTOKINE

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

The role of CXCL12 in tumor microenvironment

(2018) Wenfang Meng et al.   GENE

Targeting the CXCL12/CXCR4 pathway and myeloid cells to improve radiation treatment of locally advanced cervical cancer

(2018) Magali Lecavalier-Barsoum et al.   INTERNATIONAL JOURNAL OF CANCER

GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation which drives PI3Kγ/PREX1 signaling and T cell cytokine secretion

(2018) Brittney A Dinkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function

(2018) Laura Martínez-Muñoz et al.   MOLECULAR CELL

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

(2018) Anne-Marie Givel et al.   Nature Communications

Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex

(2018) Xianlong Gao et al.   Scientific Reports

Targeting the MIF/CXCR7/AKT Signaling Pathway in Castration-resistant Prostate Cancer

(2018) Li Jia et al.   MOLECULAR CANCER RESEARCH

Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity

(2018) Gianluca D'Agostino et al.   Frontiers in Immunology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction of Zap70 and CXCR4 receptor at lamellipodia that determines the directionality during Jurkat T cells chemotaxis

(2017) Chia-Yun Wu et al.   MOLECULAR IMMUNOLOGY

CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor

(2017) Martin Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

(2017) Laura Pellegrini et al.   Oncotarget

CXCR4+FOXP3+CD25+ Lymphocytes Accumulate in CXCL12-Expressing Malignant Pleural Mesothelioma

(2017) Y. Shimtzu et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure

(2016) Yang-Hee Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

(2016) Anoop Babu Vasandan et al.   Scientific Reports

Induction of Regulatory B-Cells by Mesenchymal Stem Cells is Affected by SDF-1α-CXCR7

(2015) Yan Qin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Differentiation and maintenance of long-lived plasma cells

(2015) Kohei Kometani et al.   CURRENT OPINION IN IMMUNOLOGY

CXCL12 Regulates through JAK1 and JAK2 Formation of Productive Immunological Synapses

(2015) Graciela Cascio et al.   JOURNAL OF IMMUNOLOGY

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7

(2015) Haruko Hayasaka et al.   PLoS One

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function

(2015) Abhishek Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

M1 and M2: there is no “good” and “bad”—How macrophages promote malignancy-associated features in tumorigenesis

(2014) Ole Helm et al.   OncoImmunology

Atypical chemokine receptors: from silence to sound

(2013) Cinzia Cancellieri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulatory T cells, interleukin (IL)-6, IL-8, Vascular endothelial growth factor (VEGF), CXCL10, CXCL11, epidermal growth factor (EGF) and hepatocyte growth factor (HGF) as surrogate markers of host immunity in patients with renal cell carcinoma

(2013) Marianeve Polimeno et al.   BJU INTERNATIONAL

Radiation Therapy-Induced Tumor Invasiveness Is Associated with SDF-1-Regulated Macrophage Mobilization and Vasculogenesis

(2013) Shu-Chi Wang et al.   PLoS One

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions

(2012) Patricia Rueda et al.   CIRCULATION

Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history

(2012) Hisayuki Nomiyama et al.   GENES TO CELLS

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

(2012) Frauke Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

CXCR7 impact on CXCL12 biology and disease

(2012) Lorena Sánchez-Martín et al.   TRENDS IN MOLECULAR MEDICINE

CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

(2011) E. Righi et al.   CANCER RESEARCH

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration

(2011) Yanling Wang et al.   NEURON

Hematopoietic stem and progenitor cell trafficking

(2011) Irina B. Mazo et al.   TRENDS IN IMMUNOLOGY

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitor of NF- B Kinases   and   Are Both Essential for High Mobility Group Box 1-Mediated Chemotaxis

(2010) M. Penzo et al.   JOURNAL OF IMMUNOLOGY

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation

(2008) Oscar M. Pello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the κ-opioid receptor

(2008) Matthew J. Finley et al.   JOURNAL OF NEUROIMMUNOLOGY

Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with CD47

(2008) Deborah Hatherley et al.   MOLECULAR CELL