Article
Biochemistry & Molecular Biology
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Wenqing Feng, Xiaoyue Sun, Geoffrey E. Hespe, Zijun Wang, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Evan T. Keller, Jun Ma, Jung-Sun Cho, Jingwen Yang, Stephen J. Weiss
Summary: Osteoclasts undergo transcriptional and metabolic changes during differentiation to acquire the cellular machinery for bone resorption. Zeb1, a zinc-finger transcriptional repressor, is found to play a role in osteoclast energy metabolism. By repressing a crucial enzyme involved in ATP buffering and mitochondrial respiration, Zeb1 controls the activity of osteoclasts and influences bone remodeling. This study reveals a novel Zeb1/MtCK1 axis that regulates bone resorption through metabolic control.
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Shumin Wang, Eri O. Maruyama, John Martinez, Justin Lopes, Trunee Hsu, Wencheng Wu, Wei Hsu, Takamitsu Maruyama, Ritu Trivedi
Summary: miRNA is an ideal master regulator for organogenesis due to its ability to simultaneously modulate a set of genes for lineage-specific development. However, the lack of obvious phenotypic defects in most miRNA deletions may be attributed to functional redundancy. Our study identifies MIR27a as a specific miRNA essential for bone homeostasis, as its loss causes severe osteoporosis in mice. MIR27a affects bone resorption by osteoclasts and not bone formation by osteoblasts, and its effects are mediated through the regulation of Squstm1/p62.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Perry C. Caviness, Dongzheng Gai, Oxana P. Lazarenko, Michael L. Blackburn, Fenghuang Zhan, Jin-Ran Chen
Summary: Osteoclasts derived from hematopoietic stem cells play a crucial role in bone resorption. Identifying new molecules that can epigenetically regulate osteoclastogenesis is essential for the development of novel treatments for bone deterioration disorders like osteoporosis. The protein Ezh2 has been found to be associated with the epigenetic regulation of various cellular processes, but its role in bone cell development is still not fully understood.
Article
Biochemistry & Molecular Biology
Hye Jung Ihn, Jiwon Lim, Kiryeong Kim, Sang-Hyeon Nam, Soomin Lim, Su Jeong Lee, Jong-Sup Bae, Tae Hoon Kim, Jung-Eun Kim, Moon-Chang Baek, Yong Chul Bae, Eui Kyun Park
Summary: Ciclopirox effectively inhibits osteoclast differentiation and bone resorption both in vitro and in vivo, making it a potential candidate for preventing osteoporosis and other osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, Masaaki Mawatari, Akiko Kukita
Summary: Bhlhe40 is a crucial regulator of osteoclast differentiation and function, and its deficiency leads to increased bone volume and reduced bone resorption activity. Analysis of potential target genes reveals their association with proton transport and intracellular vesicle acidification.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongzhou Shen, Yu Zhuang, Chenglong Zhang, Changru Zhang, Yuan Yuan, Hongbo Yu, Jiawen Si, Guofang Shen
Summary: This study investigated the value of applying BMP2-loaded calcium phosphate cement in restoring large-scale alveolar bone defects. The results showed that BMP2-CPC can induce favorable bone regeneration and remodeling, accompanied by active osteoclast formation and optimized biomaterial resorption. Osteoclasts played a multifaceted role in the bone regeneration process by promoting osteogenic differentiation and biomaterial remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Endocrinology & Metabolism
Megan M. Weivoda, Elizabeth W. Bradley
Summary: Bone remodeling is crucial for maintaining bone quality by removing and replacing damaged and old bone. This process requires tight coordination between bone resorption and bone formation. Besides osteoclasts and osteoblasts, macrophages and other myeloid lineage cells have been found to support bone remodeling. This article discusses the origin and functions of macrophages in the bone microenvironment, including tissue resident macrophages, osteomacs, and newly identified osteomorphs resulting from osteoclast fission. The role of macrophages in inflammatory bone resorption is also touched upon.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jin-Young Lee, Da-Ae Kim, Eun-Young Kim, Eun-Ju Chang, So-Jeong Park, Beom-Jun Kim
Summary: Lumican inhibits osteoclastogenesis by suppressing Akt activity, leading to an osteoprotective role by simultaneously increasing bone formation and decreasing bone resorption, suggesting it represents a dual-action therapeutic target for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Kai Yang, Shunyao Li, Tianqi Wang, Xueming Yan, Qian He, Ruonan Ning, Xing Xu, Wei Yao, Xiaofei Zhang, Chunhao Yang, Min Jiang, Lianfu Deng
Summary: Y1693, a small-molecule inhibitor of RANKL, was found to effectively prevent bone resorption and rescue alveolar bone loss caused by periodontal disease. It showed good tolerability and efficacy in an orally administered mouse model of osteoporosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pedro P. C. de Souza, Petra Henning, Ulf H. Lerner
Summary: Oncostatin M (OSM) is a potent stimulator of osteoclast formation and plays a significant role in bone remodeling by inducing RANKL in osteoblasts. Gene deletion of Osmr in mice leads to decreased osteoclast numbers and increased trabecular bone thickness. OSM can promote osteoblast differentiation and mineralization, but in vivo administration in adult animals does not significantly increase osteoclast formation due to the negative feedback loop through the osteoclastogenesis inhibitor WNT16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jiancheng Yang, Jiawen Wu, Zengfeng Guo, Gejing Zhang, Hao Zhang
Summary: This article reviews the individual and combined effects of iron oxide nanoparticles (IONPs) and static magnetic fields (SMFs) on bone remodeling. IONPs enter cells through endocytosis, promoting osteogenic differentiation and inhibiting osteoclastogenesis, while SMFs enhance osteoblast differentiation and hinder osteoclastic differentiation. When exposed to an SMF, IONPs and SMFs synergistically enhance their respective effects on osteoblasts and osteoclasts.
Article
Chemistry, Medicinal
Yifeng Shi, Lin Ye, Shiwei Shen, Tianchen Qian, Youjin Pan, Yuhan Jiang, Jinghao Lin, Chen Liu, Yaosen Wu, Xiangyang Wang, Jiake Xu, Haiming Jin
Summary: The study demonstrated that morin can inhibit osteoclast formation through various pathways and attenuate bone loss induced by ovariectomy. This suggests that morin may be a potential therapeutic agent for postmenopausal osteoporosis treatment.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xuan Wen, Xiaogang Li, Yubin Tang, Junzhou Tang, Siru Zhou, Yangli Xie, Jingyuan Guo, Jing Yang, Xiaolan Du, Nan Su, Lin Chen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Orthopedics
S. Zhou, Z. Wang, J. Tang, W. Li, J. Huang, W. Xu, F. Luo, M. Xu, J. Wang, X. Wen, L. Chen, H. Chen, N. Su, Y. Shen, X. Du, Y. Xie, L. Chen
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Rheumatology
Junzhou Tang, Nan Su, Siru Zhou, Yangli Xie, Junlan Huang, Xuan Wen, Zuqiang Wang, Quan Wang, Wei Xu, Xiaolan Du, Hangang Chen, Lin Chen
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Rheumatology
Tujun Weng, Lingxian Yi, Junlan Huang, Fengtao Luo, Xuan Wen, Xiaolan Du, Qian Chen, Chuxia Deng, Di Chen, Lin Chen
ARTHRITIS AND RHEUMATISM
(2012)
Article
Biochemistry & Molecular Biology
Yaozong Zhang, Nan Su, Fengtao Luo, Xuan Wen, Yubin Tang, Jing Yang, Siyu Chen, Wanling Jiang, Xiaolan Du, Lin Chen
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2014)
Article
Endocrinology & Metabolism
Nan Su, Maomao Chen, Siyu Chen, Can Li, Yangli Xie, Ying Zhu, Yaozong Zhang, Ling Zhao, Qifen He, Xiaolan Du, Di Chen, Lin Chen
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Chemistry, Multidisciplinary
Yan Wang, Lanlan Li, Yongchang Ma, Yong Tang, Yang Zhao, Zimeng Li, Wendan Pu, Bo Huang, Xuan Wen, Xiaojuan Cao, Jiafei Chen, Wei Chen, Yue Zhou, Jianxiang Zhang
Article
Biology
Shuo Huang, Min Jin, Nan Su, Lin Chen
Summary: Bone has a strong regenerative capacity driven by reparative cells such as skeletal stem cells and their descendants, playing critical roles in bone development, maintenance, and injury healing. However, the identity and functional roles of skeletal stem cells remain controversial due to technological difficulties and cell heterogeneity. There has been a biased view for many years that bone marrow is the main source of reparative cells for bone repair.
BIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Yangli Xie, Nan Su, Jing Yang, Qiaoyan Tan, Shuo Huang, Min Jin, Zhenhong Ni, Bin Zhang, Dali Zhang, Fengtao Luo, Hangang Chen, Xianding Sun, Jian Q. Feng, Huabing Qi, Lin Chen
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Review
Cell & Tissue Engineering
Nan Su, Min Jin, Lin Chen
Review
Biochemistry & Molecular Biology
Nan Su, Jing Yang, Yangli Xie, Xiaolan Du, Hangang Chen, Hong Zhou, Lin Chen
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)