Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes

The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype

(2021) Sven E. Niklander et al.   JOURNAL OF CELL SCIENCE

The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression

(2021) Lee Peng Karen-Ng et al.   Cancers

Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

(2020) Narmen Azazmeh et al.   Nature Communications

Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42MAPK signaling

(2020) Fatouma Alimirah et al.   CANCER RESEARCH

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

(2020) Shuling Song et al.   Advanced Science

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy

(2019) Ratna Veeramachaneni et al.   Scientific Reports

Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining

(2018) D. Vicky de Boer et al.   MOLECULAR CANCER RESEARCH

Regulation of ATM and ATR by SMARCAL1 and BRG1

(2018) Ramesh Sethy et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

(2018) Amina M Abdul-Aziz et al.   BLOOD

The genomic road to invasion—examining the similarities and differences in the genomes of associated oral pre-cancer and cancer samples

(2017) Henry M. Wood et al.   Genome Medicine

Fibroblast activation and senescence in oral cancer

(2016) S. S. Prime et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism

(2016) Emma L. James et al.   Scientific Reports

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

(2015) Stella Suyong Lee et al.   Cell Reports

Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

(2014) Jing Jiao et al.   MOLECULAR CANCER RESEARCH

Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo

(2014) MING QIAN et al.   ONCOLOGY REPORTS

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

(2014) E. C. de Bruin et al.   SCIENCE

The Cyclooxygenase-2–Prostaglandin E2Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts

(2013) Maylis Dagouassat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase Ib and Pharmacokinetic Study

(2013) N. F. Saba et al.   Cancer Prevention Research

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β

(2013) Yazan Hassona et al.   CARCINOGENESIS

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

(2012) Remi-Martin Laberge et al.   AGING CELL

p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes

(2012) Hannah S. E. Tivey et al.   BIOGERONTOLOGY

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice

(2011) O. Goertz et al.   BURNS

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor

(2010) Sandra Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases

(2010) Gayani Nadika Pitiyage et al.   JOURNAL OF PATHOLOGY

A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation

(2010) Aline Correa Abrahao et al.   ORAL ONCOLOGY

Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States

(2009) Shlok Gupta et al.   INTERNATIONAL JOURNAL OF CANCER

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Sustained Release of Prostaglandin E1 Potentiates the Impaired Therapeutic Angiogenesis by Basic Fibroblast Growth Factor in Diabetic Murine Hindlimb Ischemia

(2008) Yuhong Huang et al.   CIRCULATION JOURNAL

A Role for Fibroblasts in Mediating the Effects of Tobacco-Induced Epithelial Cell Growth and Invasion

(2008) J.-P. Coppe et al.   MOLECULAR CANCER RESEARCH

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY