Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation

(2021) Ryuichi Kambayashi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The canine chronic atrio‐ventricular block model in cardiovascular preclinical drug research

(2021) Vera Loen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses

(2021) Ryuichi Kambayashi et al.   Frontiers in Pharmacology

Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors

(2021) Jacqueline Wen Hui Leow et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone

(2020) Ryuichi Kambayashi et al.   Cardiovascular Toxicology

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

(2020) Eric A. Evangelista et al.   Scientific Reports

Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model

(2020) Jian Lu et al.   DRUG METABOLISM AND DISPOSITION

Alternative Splicing at N Terminus and Domain I Modulates Ca V 1.2 Inactivation and Surface Expression

(2018) Peter Bartels et al.   BIOPHYSICAL JOURNAL

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes

(2018) Eunyoung Lee et al.   Drug Metabolism and Pharmacokinetics

Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids

(2018) Aneesh Karkhanis et al.   TOXICOLOGICAL SCIENCES

Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog

(2017) Alexandre Bossu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites

(2016) Aneesh Karkhanis et al.   BIOCHEMICAL PHARMACOLOGY

Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo

(2016) Suchitra Matsukura et al.   Cardiovascular Toxicology

Drugs That May Cause or Exacerbate Heart Failure

(2016) Robert L. Page et al.   CIRCULATION

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Torsade de Pointes Tachycardia in a Patient on Dronedarone Therapy

(2015) Martin Huemer et al.   PHARMACOTHERAPY

Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype

(2015) Ana F. Branco et al.   PLoS One

From beat rate variability in induced pluripotent stem cell–derived pacemaker cells to heart rate variability in human subjects

(2014) Meital Ben-Ari et al.   HEART RHYTHM

Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy

(2013) Ahmed A. El-Sherbeni et al.   BIOCHEMICAL PHARMACOLOGY

Kubios HRV – Heart rate variability analysis software

(2013) Mika P. Tarvainen et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds-synthesis andin vitrometabolism of deuterated derivatives of dronedadrone

(2013) Joseph Schofield et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Pleiotropic actions of amiodarone: still puzzling after half a century

(2013) Jordi Heijman et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy

(2013) Christina Westphal et al.   PLoS One

Hypotheses, rationale, design, and methods for prognostic evaluation of cardiac biomarker elevation after percutaneous and surgical revascularization in the absence of manifest myocardial infarction. A comparative analysis of biomarkers and cardiac magnetic resonance. The MASS-V Trial

(2012) Whady Hueb et al.   BMC Cardiovascular Disorders

Human Embryonic and Induced Pluripotent Stem Cell–Derived Cardiomyocytes Exhibit Beat Rate Variability and Power-Law Behavior

(2012) Yael Mandel et al.   CIRCULATION

Possible Proarrhythmia with Dronedarone

(2012) JONATHAN ROSMAN et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Pharmacoelectrophysiology of Viral-Free Induced Pluripotent Stem Cell–Derived Human Cardiomyocytes

(2012) Ashish Mehta et al.   TOXICOLOGICAL SCIENCES

Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells

(2011) Ashish Mehta et al.   CARDIOVASCULAR RESEARCH

Dronedarone in High-Risk Permanent Atrial Fibrillation

(2011) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism

(2010) Veronique Michaud et al.   PLoS One

Relation of Increased Short-Term Variability of QT Interval to Congenital Long-QT Syndrome

(2009) Martin Hinterseer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity

(2009) Yunfang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dronedarone

(2009) Chinmay Patel et al.   CIRCULATION

Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells

(2009) Limor Zwi et al.   CIRCULATION

Identification of Novel Substrates for Human Cytochrome P450 2J2

(2009) C. A. Lee et al.   DRUG METABOLISM AND DISPOSITION

Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo

(2009) C. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sensitive and reliable proarrhythmiain vivoanimal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

(2008) A Sugiyama   BRITISH JOURNAL OF PHARMACOLOGY

Increased Mortality after Dronedarone Therapy for Severe Heart Failure

(2008) Lars Køber et al.   NEW ENGLAND JOURNAL OF MEDICINE