When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer

Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

(2021) Yael C. Cohen et al.   NATURE MEDICINE

Non-canonical PD-1 signaling in cancer and its potential implications in clinic

(2021) Haoran Zha et al.   Journal for ImmunoTherapy of Cancer

Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation

(2021) Zachary Davis et al.   Blood Advances

The Role of Trogocytosis in the Modulation of Immune Cell Functions

(2021) Kensuke Miyake et al.   Cells

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

(2021) Veronica D. Gonzalez et al.   Cell Reports

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma

(2020) Masaharu Kawashima et al.   LEUKEMIA

Biting off what can be chewed: Trogocytosis in health, infection and disease

(2020) Akhila Bettadapur et al.   INFECTION AND IMMUNITY

Minimal PD-1 expression in mouse and human NK cells under diverse conditions

(2020) Sean J. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells

(2020) Giuseppe Sciumè et al.   IMMUNITY

Dissecting the NK Cell Population in Hematological Cancers Confirms the Presence of Tumor Cells and Their Impact on NK Population Function

(2020) Dang-Nghiem Vo et al.   Vaccines

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

Trogocytosis-Mediated Intracellular Signaling in CD4+ T Cells Drives TH2-Associated Effector Cytokine Production and Differentiation

(2019) Jim Reed et al.   JOURNAL OF IMMUNOLOGY

The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector

(2019) Wenjuan Dong et al.   Cancer Discovery

Killers 2.0: NK cell therapies at the forefront of cancer control

(2019) Jonathan J. Hodgins et al.   JOURNAL OF CLINICAL INVESTIGATION

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

(2019) Michael Ruzicka et al.   LEUKEMIA

Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation

(2019) Olga M. Anton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling

(2018) Makoto Nakashima et al.   BIOLOGY OF THE CELL

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

(2018) Frank Vari et al.   BLOOD

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

(2017) Silvia Pesce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control

(2017) Christian Schwartz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

(2017) Y Liu et al.   ONCOGENE

Trogocytosis of peptide–MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils

(2017) Kensuke Miyake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality

(2016) Han-Yu Shih et al.   CELL

Immunosurveillance and immunotherapy of tumors by innate immune cells

(2016) Alexandre Iannello et al.   CURRENT OPINION IN IMMUNOLOGY

SLAM family receptors in normal immunity and immune pathologies

(2016) Ning Wu et al.   CURRENT OPINION IN IMMUNOLOGY

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1

(2016) Huaijian Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

(2016) Emily Curran et al.   Cell Reports

FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

(2015) Rony Dahan et al.   CANCER CELL

Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive

(2015) Cathrine A. Miner et al.   JOURNAL OF IMMUNOLOGY

Fc -receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

(2014) R. P. Taylor et al.   BLOOD

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors

(2014) Michele Ardolino et al.   JOURNAL OF CLINICAL INVESTIGATION

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Imprinting of Lymphocytes with Melanoma Antigens Acquired by Trogocytosis Facilitates Identification of Tumor-Reactive T Cells

(2013) G. Eisenberg et al.   JOURNAL OF IMMUNOLOGY

T Cells at the Site of Autoimmune Inflammation Show Increased Potential for Trogocytosis

(2013) Bettina Haastert et al.   PLoS One

Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand

(2013) Kyohei Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

(2012) R. Brown et al.   BLOOD

Expression of CD137 on Hodgkin and Reed-Sternberg Cells Inhibits T-cell Activation by Eliminating CD137 Ligand Expression

(2012) W. T. Ho et al.   CANCER RESEARCH

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

(2011) E. Narni-Mancinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections

(2010) Kerstin Rosenits et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Direction of Plasma Membrane Exchange between Lymphocytes and Accessory Cells by Trogocytosis Is Influenced by the Nature of the Accessory Cell

(2010) Sandrine Daubeuf et al.   JOURNAL OF IMMUNOLOGY

Ligand Binding but Undetected Functional Response of FcR after Their Capture by T Cells via Trogocytosis

(2009) D. Hudrisier et al.   JOURNAL OF IMMUNOLOGY

Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells

(2008) A. Aucher et al.   BLOOD

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY