Delivery of nVEGFi using AAV8 for the treatment of neovascular age-related macular degeneration

Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates

(2020) Glenn Yiu et al.   Molecular Therapy-Methods & Clinical Development

Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

(2020) Thilo Buck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update

(2020) Fan-Li Lin et al.   MOLECULAR THERAPY

Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety

(2020) Kirsten Bucher et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Adeno-Associated Viral Gene Therapy for Inherited Retinal Disease

(2019) Tuyen Ong et al.   PHARMACEUTICAL RESEARCH

AAVcis-regulatory sequences are correlated with ocular toxicity

(2019) Wenjun Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene delivery to cone photoreceptors by subretinal injection of rAAV2/6 in the mouse retina

(2019) Tesshu Hori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat

(2019) Mariana S. Dias et al.   GENE THERAPY

AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression

(2019) Kun Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration

(2018) Yuanyuan Liu et al.   MOLECULAR THERAPY

CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration

(2018) Taeyoung Koo et al.   Nature Communications

Nonclinical Safety Evaluation of scAAV8- RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

(2018) Timothy K. MacLachlan et al.   Molecular Therapy-Methods & Clinical Development

Dosage thresholds and influence of transgene cassette in AAV-related toxicity

(2018) Hanen Khabou et al.   HUMAN GENE THERAPY

Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization

(2018) Manas R. Biswal et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD

(2018) Christopher A. Reid et al.   Scientific Reports

Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration

(2018) Ruslan Grishanin et al.   MOLECULAR THERAPY

Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration

(2017) Kyoungmi Kim et al.   GENOME RESEARCH

Lentiviral Vector Gene Transfer of Endostatin/Angiostatin for Macular Degeneration (GEM) Study

(2017) Peter A. Campochiaro et al.   HUMAN GENE THERAPY

Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial

(2017) Jeffrey S Heier et al.   LANCET

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

(2017) Eunji Kim et al.   Nature Communications

Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs

(2017) Anne Louise Askou et al.   Human Gene Therapy Methods

In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells

(2017) Andreas Holmgaard et al.   Molecular Therapy-Nucleic Acids

Cone-Specific Promoters for Gene Therapy of Achromatopsia and Other Retinal Diseases

(2016) Guo-Jie Ye et al.   HUMAN GENE THERAPY

AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy

(2016) Astra Dinculescu et al.   PLoS One

METAANALYSIS OF REAL-WORLD OUTCOMES OF INTRAVITREAL RANIBIZUMAB FOR THE TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

(2016) Leah N. Kim et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial

(2015) Elizabeth P Rakoczy et al.   LANCET

Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors

(2015) Anne Louise Askou et al.   Molecular Therapy-Methods & Clinical Development

Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice

(2015) Yan Gong et al.   PLoS One

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates

(2014) M A Kotterman et al.   GENE THERAPY

Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

(2014) J.-E. Lee et al.   MOLECULAR CANCER THERAPEUTICS

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature

(2013) K Ghasemi Falavarjani et al.   EYE

Absolute Determination of Single-Stranded and Self-Complementary Adeno-Associated Viral Vector Genome Titers by Droplet Digital PCR

(2013) Martin Lock et al.   Human Gene Therapy Methods

Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA

(2012) Anne Louise Askou et al.   JOURNAL OF GENE MEDICINE

Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

(2011) L. H. Vandenberghe et al.   Science Translational Medicine

Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

(2010) Martin Lock et al.   HUMAN GENE THERAPY

Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

(2010) Timothy K MacLachlan et al.   MOLECULAR THERAPY

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling