Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat

Methods to Induce Chronic Ocular Hypertension

(2018) Ashim Dey et al.   CELL TRANSPLANTATION

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

(2018) Pasqualina Colella et al.   Molecular Therapy-Methods & Clinical Development

EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy

(2018) Xin Ju et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The challenge of regenerative therapies for the optic nerve in glaucoma

(2017) David J. Calkins et al.   EXPERIMENTAL EYE RESEARCH

Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina

(2017) Pavitra S. Ramachandran et al.   HUMAN GENE THERAPY

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward

(2017) Jean Bennett   MOLECULAR THERAPY

Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

(2017) Kazuhisa Takahashi et al.   MOLECULAR THERAPY

Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases

(2017) Yingqian Peng et al.   OPHTHALMIC RESEARCH

Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs

(2016) R F Boyd et al.   GENE THERAPY

Heparan Sulfate Binding Promotes Accumulation of Intravitreally Delivered Adeno-associated Viral Vectors at the Retina for Enhanced Transduction but Weakly Influences Tropism

(2016) Kenton T. Woodard et al.   JOURNAL OF VIROLOGY

Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors

(2016) Sanford L. Boye et al.   JOURNAL OF VIROLOGY

Intravitreal infusion: A novel approach for intraocular drug delivery

(2016) Jiao Tian et al.   Scientific Reports

Photoreceptor-targeted gene delivery using intravitreally administered AAV vectors in dogs

(2015) R F Boyd et al.   GENE THERAPY

GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model

(2015) L.-D. Dong et al.   JOURNAL OF NEUROSCIENCE

Survey of intravitreal injection techniques and treatment protocols among retina specialists in Canada

(2014) Lin Xing et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure

(2014) A H Chaanine et al.   GENE THERAPY

Vitreous Substitutes: The Present and the Future

(2014) Simone Donati et al.   Biomed Research International

Inhibition of EGF Signaling Protects the Diabetic Retina from Insulin-Induced Vascular Leakage

(2013) Masahiko Sugimoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Direct Comparison of Administration Routes for AAV8-mediated Ocular Gene Therapy

(2013) Tsutomu Igarashi et al.   CURRENT EYE RESEARCH

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach

(2013) F M Mowat et al.   GENE THERAPY

Arsenic Trioxide Stabilizes Accumulations of Adeno-Associated Virus Virions at the Perinuclear Region, Increasing Transduction In Vitro and In Vivo

(2013) A. M. Mitchell et al.   JOURNAL OF VIROLOGY

The Protective Effects of the Proteasome Inhibitor Bortezomib (Velcade) on Ischemia-Reperfusion Injury in the Rat Retina

(2013) Fang-Ting Chen et al.   PLoS One

Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs

(2013) Ashlee R. Bruewer et al.   PLoS One

Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo

(2013) Nishanth Gabriel et al.   Human Gene Therapy Methods

Celastrol enhances AAV1-mediated gene expression in mice adipose tissues

(2010) F-L Zhang et al.   GENE THERAPY

Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application

(2010) Paul E Monahan et al.   MOLECULAR THERAPY

Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina

(2010) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous

(2009) Deniz Dalkara et al.   MOLECULAR THERAPY

Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization

(2008) P Pechan et al.   GENE THERAPY

Enhancement of Adeno-Associated Virus Infection by Mobilizing Capsids into and Out of the Nucleolus

(2008) J. S. Johnson et al.   JOURNAL OF VIROLOGY

High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

(2008) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

(2008) L. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA