Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1

Defining the underlying defect in insulin action in type 2 diabetes

(2021) Thiago M. Batista et al.   DIABETOLOGIA

Nitrate attenuates HFD‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission

(2020) Henver S. Brunetta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

(2019) Kelsey H. Fisher-Wellman et al.   Cell Reports

Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload

(2019) Maria-Nieves Sanz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction

(2019) Ashley S. Williams et al.   Cell Metabolism

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

(2019) M. Peleli et al.   Redox Biology

Metabolic Effects of Dietary Nitrate in Health and Disease

(2018) Jon O. Lundberg et al.   Cell Metabolism

High Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity

(2018) Paula M Miotto et al.   DIABETES

Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism

(2018) Yongting Luo et al.   Oxidative Medicine and Cellular Longevity

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

(2018) Isabel Cordero-Herrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport

(2016) P. M. Miotto et al.   BIOCHEMICAL JOURNAL

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins

(2016) Michael N. Davies et al.   Cell Reports

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

(2015) Louise Lantier et al.   DIABETES

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats

(2015) Arend Bonen et al.   DIABETOLOGIA

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

(2015) B. T. Weinert et al.   EMBO JOURNAL

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

(2014) Amanda T. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adenine Nucleotide Translocase Is Acetylated in Vivo in Human Muscle: Modeling Predicts a Decreased ADP Affinity and Altered Control of Oxidative Phosphorylation

(2014) Clinton Mielke et al.   BIOCHEMISTRY

High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII

(2014) Swati S. Jain et al.   DIABETES

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

(2013) A. T. White et al.   DIABETOLOGIA

Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol

(2013) Brennan K. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation

(2009) Graham P. Holloway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism