ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo

(2020) Zhuang Wang et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1

(2020) Ganeshkumar Rajendran et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

(2020) Zhaoxin Hu et al.   Cell Death & Disease

Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling

(2020) Chengcheng Xiao et al.   Frontiers in Physiology

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

(2020) Yue Wang et al.   Journal of Advanced Research

Iron, ferroptosis, and new insights for prevention in acute kidney injury

(2020) Bartlomiej Borawski et al.   Advances in Medical Sciences

Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor

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XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

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Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway

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Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair

(2019) Shaoqun Shu et al.   Cells

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

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Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI

(2019) Shrikant Ramesh Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice

(2019) Xiao-Yuan Mao et al.   Frontiers in Neuroscience

Thiazolidinediones: the Forgotten Diabetes Medications

(2019) Harold E. Lebovitz   Current Diabetes Reports

Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

(2018) Kathryn Prame Kumar et al.   CELL AND TISSUE RESEARCH

Nephropreventing effect of hypoxia-inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury

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Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

(2018) Yunwen Yang et al.   CLINICAL SCIENCE

MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury

(2018) Qingqing Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

The leukotriene B 4 –leukotriene B 4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment

(2017) Bo Deng et al.   KIDNEY INTERNATIONAL

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis: process and function

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Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Predictors of Recurrent AKI

(2015) E. D. Siew et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Necroinflammation in Kidney Disease

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immune cells in experimental acute kidney injury

(2014) Hye Ryoun Jang et al.   Nature Reviews Nephrology

Role of Hypoxia-Inducible Factors in Acute Kidney Injury

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Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

(2013) Abolfazl Zarjou et al.   JOURNAL OF CLINICAL INVESTIGATION

Tubular von Hippel-Lindau Knockout Protects against Rhabdomyolysis-Induced AKI

(2013) M. Fahling et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Raising awareness of acute kidney injury: a global perspective of a silent killer

(2013) Andrew J.P. Lewington et al.   KIDNEY INTERNATIONAL

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noxious Stimulation Attenuates Ketamine-induced Neuroapoptosis in the Developing Rat Brain

(2012) Jia-Ren Liu et al.   ANESTHESIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury

(2012) Helena Block et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy protects proximal tubular cells from injury and apoptosis

(2012) Gur P. Kaushal   KIDNEY INTERNATIONAL

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

A Unique Hybrid Renal Mononuclear Phagocyte Activation Phenotype in Murine Systemic Lupus Erythematosus Nephritis

(2011) R. Bethunaickan et al.   JOURNAL OF IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

An overview of drug-induced acute kidney injury

(2008) Neesh Pannu et al.   CRITICAL CARE MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY