Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1

Endothelial HIF-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through FoxM1

(2019) Xiaojia Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

(2019) Atsushi Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation

(2018) Qiying Fan et al.   AMERICAN JOURNAL OF PATHOLOGY

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

(2017) Pranvera Sadiku et al.   JOURNAL OF CLINICAL INVESTIGATION

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

(2016) Benjamin A. Olenchock et al.   CELL

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

(2016) Hanako Kobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice

(2016) Pinelopi P. Kapitsinou et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

(2016) Lexiao Li et al.   NEUROBIOLOGY OF DISEASE

The Changing Landscape of Renal Inflammation

(2016) Thomas Ernandez et al.   TRENDS IN MOLECULAR MEDICINE

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury

(2016) Yi Fang et al.   Oncotarget

Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement PathwaysNovelty and Significance

(2015) Andreas Skyschally et al.   CIRCULATION RESEARCH

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney injury is independent of endothelial HIF-1α

(2015) Joanna Kalucka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cell-specific translational profiling in acute kidney injury

(2014) Jing Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic translation in acute kidney injury: the epithelial/endothelial axis

(2014) Bruce A. Molitoris   JOURNAL OF CLINICAL INVESTIGATION

Raising awareness of acute kidney injury: a global perspective of a silent killer

(2013) Andrew J.P. Lewington et al.   KIDNEY INTERNATIONAL

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection

(2013) Risto Kerkelä et al.   MOLECULAR AND CELLULAR BIOLOGY

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells

(2012) Vincenzo Cantaluppi et al.   KIDNEY INTERNATIONAL

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

(2012) Reiner Kunze et al.   STROKE

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species

(2011) Randy J. Giedt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Physiology of Renal Hypoxiaa

(2010) FRANKLIN H. EPSTEIN et al.   Annals of the New York Academy of Sciences

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD