Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss

(2021) Xiaoguang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Benzylidene, 5-benzyl, and 3-benzylthiazolidine-2,4-diones as potential inhibitors of the mitochondrial pyruvate carrier: Effects on mitochondrial functions and survival in Drosophila melanogaster

(2021) Mohamed Touaibia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases

(2020) Jinyi Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state

(2019) Sotiria Tavoulari et al.   EMBO JOURNAL

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

(2019) Sean C. Tompkins et al.   Cell Reports

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex

(2019) Yu Yamashita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiazolidinediones as antidiabetic agents: A critical review

(2018) M.J. Nanjan et al.   BIOORGANIC CHEMISTRY

MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis

(2018) Jerry R. Colca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

(2018) Emmanuel Quansah et al.   Molecular Neurodegeneration

Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells

(2018) David Grünig et al.   TOXICOLOGICAL SCIENCES

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

(2018) Cyril Corbet et al.   Nature Communications

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

(2018) Raghavendra Sashi Krishna Nagampalli et al.   Scientific Reports

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

(2017) Kyle S. McCommis et al.   HEPATOLOGY

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

(2017) Ajit S. Divakaruni et al.   JOURNAL OF CELL BIOLOGY

The catechol- O -methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

(2017) David Grünig et al.   TOXICOLOGY IN VITRO

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells

(2016) Benoît Vanderperre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease

(2016) A. Ghosh et al.   Science Translational Medicine

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

(2015) Lawrence R. Gray et al.   Cell Metabolism

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes

(2015) T. Bender et al.   EMBO JOURNAL

Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers

(2015) Paul G. Crichton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

(2015) Vincent Compan et al.   MOLECULAR CELL

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

(2014) Raj Shah et al.   Current Alzheimer Research

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers

(2014) Chancievan Thangaratnarajah et al.   Nature Communications

Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

(2013) Jerry R Colca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina

(2013) Jianhai Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Metabolic effects of silibinin in the rat liver

(2011) Carina Parisoto Colturato et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Static light scattering to characterize membrane proteins in detergent solution

(2008) Dirk Jan Slotboom et al.   METHODS