Article
Medicine, Research & Experimental
Mellina S. Simoes, Ana Paula Ames-Sibin, Emanuele P. Lima, Vanesa O. Pateis, Ciomar A. Bersani-Amado, Paulo C. F. Mathias, Rosane M. Peralta, Anacharis B. Sa-Nakanishi, Livia Bracht, Adelar Bracht, Jurandir F. Comar
Summary: Resveratrol inhibited glycogen catabolism and gluconeogenesis in healthy and arthritic rat livers, with a higher sensitivity in arthritic rats. It also partially inhibited mitochondrial respiration and the activities of NADH-and succinate-oxidases. The metabolite R3G had a lower impact on gluconeogenesis but a higher impact on glycogen catabolism compared to resveratrol.
Article
Cell Biology
Brandon T. Hubbard, Traci E. LaMoia, Leigh Goedeke, Rafael C. Gaspar, Katrine D. Galsgaard, Mario Kahn, Graeme F. Mason, Gerald I. Shulman
Summary: We have developed a method (Q-Flux) to measure the absolute rates of both forward (V-SDH(F)) and reverse (V-SDH(R)) flux through SDH in vivo and to deconvolute the glucose derived from four carbon sources in the liver. Q-Flux provides a comprehensive picture of hepatic mitochondrial metabolism and can be widely used by researchers.
Review
Oncology
Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Summary: Pyruvate carboxylase (PC) is a mitochondrial enzyme that plays an essential role in controlling whole-body energetics in nonmalignant tissue and is linked to pulmonary metastasis in breast cancer. Its activity is particularly important in cancer cells unable to utilize glutamine for anaplerosis, and it also plays a role in lipid metabolism and protection from oxidative stress in cancer cells.
CANCER & METABOLISM
(2021)
Article
Cell Biology
Feng Cai, Divya Bezwada, Ling Cai, Rohit Mahar, Zheng Wu, Mario C. Chang, Panayotis Pachnis, Chendong Yang, Sherwin Kelekar, Wen Gu, Bailey Brooks, Bookyung Ko, Hieu S. Vu, Thomas P. Mathews, Lauren G. Zacharias, Misty Martin-Sandoval, Duyen Do, K. Celeste Oaxaca, Eunsook S. Jin, Vitaly Margulis, Craig R. Malloy, Matthew E. Merritt, Ralph J. Deberardinis
Summary: Stable isotopes are important tools for evaluating metabolism and can be detected using both mass spectrometry and nuclear magnetic resonance in vivo. We have developed a mass spectrometry method that can report all 16 aspartate and 32 glutamate isotopomers, offering higher sensitivity than nuclear magnetic resonance. This method allows for discrimination between pathways that result in the same number of 13C labels in aspartate and glutamate. Through experiments, we have demonstrated metabolic heterogeneity within human tumors, examined the impact of fumarate hydratase deficiency in renal cancer, and investigated the contributions of tricarboxylic acid cycle turnover and CO2 recycling to in vivo isotope labeling.
Article
Gastroenterology & Hepatology
Qiuyuan Yang, Yue Wu, Wei Liu, Xiaojuan Ou, Wei Zhang, Jianning Wang, Yanzhong Chang, Fudi Wang, Ming Gao, Sijin Liu
Summary: Our study explores the role of iron in liver lipid metabolism and finds that iron overload can disrupt the normal distribution of lipids within the liver, particularly in the periportal zone. Through gene expression analysis in both the pericentral and periportal zones, we identify pyruvate carboxylase (PC) as a key regulator in iron overload-induced lipid accumulation. We also reveal that the activation of cyclic adenosine monophosphate response element binding protein (CREB) is essential for Pc gene expression in response to iron overload.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Siraprapa Siritutsoontorn, Witchuda Sukjoi, Steven W. Polyak, Chareeporn Akekawatchai, Sarawut Jitrapakdee
Summary: HLCS plays a crucial role in breast cancer growth and migration by promoting the biotinylation of carboxylases. Depletion of biotin or reduced expression of HLCS inhibits cell proliferation and migration, leading to apoptosis in breast cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Madeline P. Sheeley, Violet A. Kiesel, Chaylen Andolino, Nadia A. Lanman, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Summary: Metabolic reprogramming plays a key role in cancer progression and metastasis. In this study, the researchers investigated the effects of the bioactive metabolite of vitamin D, 1,25(OH)(2)D, on cell survival in ECM-detached conditions. They found that pretreatment with 1,25(OH)(2)D reduced cell viability in detached conditions and altered glutamine metabolism. Further analysis revealed that 1,25(OH)(2)D suppressed the expression and activity of pyruvate carboxylase (PC), a key enzyme involved in cancer cell anchorage independence. These results suggest that 1,25(OH)(2)D may suppress cancer progression by inhibiting PC and preventing anchorage independence.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Jarunya Ngamkham, Siraprapa Siritutsoontorn, Saowaluk Saisomboon, Kulthida Vaeteewoottacharn, Sarawut Jitrapakdee
Summary: PC knockout inhibits the growth and migration of HT-29 cells, and induces apoptosis upon exposure to chemotherapeutic drugs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Udom Lao-On, Timothy S. Cliff, Stephen Dalton, Sarawut Jitrapakdee
Summary: This study reveals that the ablation of the PC gene in brown adipocytes results in a 35% reduction in ATP-linked respiration, but does not affect thermogenesis, highlighting the crucial role of PC in supporting fuel oxidation rather than heat production in human brown adipocytes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Fisheries
Tiancong Ren, Haiyan Liu, Xutao Zhang, Peiyu Zhang, Qian Gao, Xinyue Jia, Tong Xu, Tongtong Yue, Zhencai Yang
Summary: Alpha-starch significantly improved the weight gain rate and specific growth rate of juvenile Chinese soft-shelled turtles compared to glucose, sucrose, and cellulose. Glucose and cellulose diets showed poor growth performance and metabolism in turtles.
AQUACULTURE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ting Linghu, Yunhao Zhao, Wenze Wu, Yao Gao, Junsheng Tian, Xuemei Qin
Summary: The severe harm of depression to human health and life has attracted global attention, but the exact mechanism is not yet known due to the complicated pathogenesis. This study focuses on mitochondrial dysfunction and reveals a metabolic reprogramming in depressed rats, including decreased TCA cycle and increased gluconeogenesis pathway. The levels of the mitochondrial pyruvate carrier (MPC) decreased significantly, suggesting MPC, PDH and PC as potential therapeutic targets for depression.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Entomology
Huan-Huan Gao, Shan Zhao, Rui-Juan Wang, Dong-Yun Qin, Peng Chen, An-Sheng Zhang, Qian-Ying Zhuang, Yi-Fan Zhai, Xian-Hong Zhou
Summary: This study found that Klebsiella oxytoca has a significant impact on the development of Drosophila suzukii, promoting its adaptability to the high-sugar ecological niche by stimulating the glycolysis/gluconeogenesis pathway. It can increase the survival rate and longevity of Drosophila suzukii by providing direct nutrition or affecting the balance of gut microbial communities. This result provides a new target for controlling Drosophila suzukii by inhibiting sugar metabolism through eliminating the effect of Klebsiella oxytoca.
Article
Biochemistry & Molecular Biology
Xin Dou, Wei-Yu Zhou, Meng Ding, Yin-Jun Ma, Qi-Qi Yang, Shu-Wen Qian, Yan Tang, Qi-Qun Tang, Yang Liu
Summary: This study found that SENP2 deficiency can protect against high-fat diet-induced hyperglycemia. SENP2 regulates hepatic gluconeogenesis through its interaction with and deSUMOylation of AMPKα, providing further understanding of the pathogenesis of T2D.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Lun Song, Xiangbo Bao, Yin Liu, Weidong Liu, Sufang Zhao, Suxuan Liu
Summary: This study investigated the physiological, immune, and metabolic effects of starvation stress at high temperatures on Mizuhopecten yessoensis, an economical bivalve mollusk in China and Japan. The results showed that long-term starvation decreased immune indexes and fertility, as well as affected carbohydrate metabolism and other processes in this species.
Article
Biology
Emine Can, Jessica A. M. Bastiaansen, Dominique-Laurent Couturier, Rolf Gruetter, Hikari A. Yoshihara, Arnaud Comment
Summary: Can et al. demonstrate the use of hyperpolarized [1-13C]pyruvate and 13C magnetic resonance to directly assess liver enzymatic activities, allowing non-invasive detection of hepatic gluconeogenesis. They found that using two- to three-fold the basal plasma concentration of hyperpolarized [1-C-13]pyruvate enables measurement of liver metabolism. The study also reveals that supraphysiological doses of hyperpolarized [1-C-13]pyruvate can saturate or partially inhibit pyruvate dehydrogenase activity.
COMMUNICATIONS BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tatiane F. Vieira, Rubia C. G. Correa, Rosely A. Peralta, Regina F. Peralta-Muniz-Moreira, Adelar Bracht, Rosane M. Peralta
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Chemistry, Applied
Geferson A. Goncalves, Raja C. G. Correa, Lillian Barros, Maria Ines Dias, Ricardo C. Calhelha, Vanesa G. Correa, Adelar Bracht, Rosane M. Peralta, Isabel C. F. R. Ferreira
Article
Chemistry, Applied
Jessica A. A. Garcia, Raja C. G. Correa, Lillian Barros, Carla Pereira, Rui M. Abreu, Maria Jose Alves, Ricardo C. Calhelha, Adelar Bracht, Rosane M. Peralta, Isabel C. F. R. Ferreira
Article
Pharmacology & Pharmacy
Lorena dos Santos Castro, Livia Bracht, Rosane Marina Peralta, Heloisa Vialle Pereira Marostica, Jurandir Fernando Comar, Anacharis Babeto de Sa-Nakanishi, Adelar Bracht
Summary: Resveratrol exhibited anti-inflammatory and antioxidant effects in rats with adjuvant-induced arthritis, with dose-dependent responses observed. It may serve as an adjuvant to conventional antirheumatic drugs.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Environmental Sciences
Emanueli Backes, Camila G. Kato, Tamires B. da Silva, Thais M. Uber, Daniela L. Pasquarelli, Adelar Bracht, Rosane M. Peralta
Summary: The study aimed to optimize laccase production by using pineapple crowns as substrate. The results showed a significant increase in laccase activity under the optimized conditions, indicating the potential of pineapple crowns as an effective substrate for laccase production.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2022)
Article
Biochemistry & Molecular Biology
Tamires Barlati Vieira da Silva, Maria Ines Dias, Carla Pereira, Filipa Mandim, Marija Ivanov, Marina Sokovic, Isabel C. F. R. Ferreira, Lillian Barros, Flavio Augusto Vicente Seixas, Adelar Bracht, Rosane Marina Peralta
Summary: Kenyan purple tea is a variety of green tea plant exclusive to Kenya, known for its purple color and high content of anthocyanin polyphenols. This study aimed to identify and quantify the major anthocyanin polyphenols in the purple tea leaves and test its ability to inhibit triglyceride absorption. The results showed that the purple tea extract had strong inhibitory effects on pancreatic lipase and triglyceride digestion, suggesting that regular consumption of Kenyan purple tea may be beneficial for obesity control.
Review
Plant Sciences
Kamila de Cassia Spacki, Rubia Carvalho Gomes Correa, Thais Marques Uber, Lillian Barros, Isabel C. F. R. Ferreira, Rosely Aparecida Peralta, Regina de Fatima Peralta Muniz Moreira, Cristiane Vieira Helm, Edson Alves de Lima, Adelar Bracht, Rosane Marina Peralta
Summary: This work is a critical review of various aspects of the peach palm plant, including its historical, botanical, social, environmental, and nutritional aspects. The cultivation of B. gasipaes has become increasingly important in Brazil, especially for the production of palm heart. Recent efforts have also focused on the potential valorization of the fruit as a source of carotenoids and starch. The lignocellulosic wastes of B. gasipaes have great potential for being upcycled into valuable biotechnological products.
Review
Plant Sciences
Jessica Amanda Andrade Garcia-Manieri, Vanesa Gesser Correa, Emanueli Backes, Anacharis Babeto de Sa-Nakanishi, Livia Bracht, Jurandir Fernando Comar, Rubia Carvalho Gomes Correa, Rosane Marina Peralta, Adelar Bracht
Summary: This review collected data on the potential hepatoprotective activity of plants from the Brazilian native flora, focusing on extraction methods, activity indicators, and identification of active compounds. Various plant parts, such as fruit peels, seeds, stem barks, and leaves, contain constituents with hepatoprotective activities. The findings have significant economic implications for rural producers.
Article
Biotechnology & Applied Microbiology
Emanueli Backes, Camila Gabriel Kato, Verci Alves de Oliveira Junior, Thais Marques Uber, Luis Felipe Oliva dos Santos, Rubia Carvalho Gomes Correa, Adelar Bracht, Rosane Marina Peralta
Summary: The effect of farnesol on laccase production by Trametes versicolor and Pycnoporus sanguineus in pineapple waste solid-state fermentation was evaluated. Farnesol induced the production of laccase in both fungi, with higher activity observed on the 17th day. Farnesol improved the oxidative state of the cultures but inhibited fungal growth.
FERMENTATION-BASEL
(2023)
Article
Gastroenterology & Hepatology
Lais Cristina Lima Silva, Gustavo Henrique de Souza, Vanesa de Oliveira Pateis, Ana Paula Ames-Sibin, Beatriz Paes Silva, Livia Bracht, Jurandir Fernando Comar, Rosane Marina Peralta, Adelar Bracht, Anacharis Babeto Sa-Nakanishi
Summary: The alkaloid boldine can reduce blood glucose levels in diabetic rats by inhibiting glucose synthesis and key enzymes in the gluconeogenic pathway. It also increases glycolysis from glycogen-derived glucosyl units. These findings may explain the mechanism behind the decrease in hyperglycemia observed in boldine-treated diabetic rats.
INTERNATIONAL JOURNAL OF HEPATOLOGY
(2023)
Article
Food Science & Technology
Lorena dos Santos Castro, Livia Bracht, Rosane Marina Peralta, Heloisa Vialle Pereira Marostica, Jurandir Fernando Comar, Anacharis Babeto de Sa-Nakanishi, Adelar Bracht
Summary: This study investigated the effects of various natural and synthetic antioxidants on free radical production and oxygen uptake in rat liver mitochondria. Sixteen antioxidants were tested, with six of them increasing free radical production and three inhibiting it at high concentrations. Some of the antioxidants also acted as inhibitors of energy metabolism. The best inhibitors of free radical production were resveratrol & AP;chlorogenic acid > epicatechin > rutin > ferulic acid. No significant correlations were found between antioxidant strength and chemical systems or the number of aromatic hydroxyls. The study suggests that mitochondrial antioxidant assay should be used alongside chemical assays when testing antioxidant preparations.
Article
Pharmacology & Pharmacy
Livia Bracht, Jorgete Constantin, Rosane Marina Peralta, Adelar Bracht
Summary: The effects of Eli Lilly-rDNA glucagon and Novo Nordisk-rDNA glucagon on glycogen catabolism and related parameters were investigated using bivascularly perfused rat livers. The study found that Eli Lilly-rDNA glucagon had a greater than expected action, possibly due to impurities that affect cell-to-cell propagation.
SCIENTIA PHARMACEUTICA
(2023)
Article
Biochemistry & Molecular Biology
Thais Marques Uber, Ana Julia dos Reis Buzzo, Gidiane Scaratti, Suelen Maria Amorim, Cristiane Vieira Helm, Giselle Maria Maciel, Rosely Aparecida Peralta, Regina de Fatima Peralta Muniz Moreira, Adelar Bracht, Rosane Marina Peralta
Summary: In this study, laccase from Oudemansiella canarii was immobilized using CLEA methodology and applied in the degradation of the anthraquinonic dye RBBR. The immobilized laccase showed enhanced thermal and storage stabilities compared to the free laccase and efficiently decolourized the dye even after multiple cycles. The study also found that the immobilized laccase from O. canarii has potential applications in degrading unwanted dyes in the environment.
BIOCATALYSIS AND BIOTRANSFORMATION
(2022)
Article
Food Science & Technology
Camila Gabriel Kato-Schwartz, Rubia Carvalho Gomes Correa, Diego de Souza Lima, Anacharis Babeto de Sa-Nakanishi, Geferson de Almeida Goncalves, Flavio Augusto Vicente Seixas, Charles W. I. Haminiuk, Lillian Barros, Isabel C. F. R. Ferreira, Adelar Bracht, Rosane Marina Peralta
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Vanesa Gesser Correa, Anacharis B. de Sa-Nakanishi, Geferson de Almeida Goncalves, Lillian Barros, Isabel C. F. R. Ferreira, Adelar Bracht, Rosane M. Peralta
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)