Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

(2021) Mohamad-Gabriel Alameh et al.   IMMUNITY

Particle-specific neutralizing activity of a monoclonal antibody targeting the poxvirus A33 protein reveals differences between cell associated and extracellular enveloped virions

(2020) Eric M. Mucker et al.   VIROLOGY

Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines

(2020) Eric M. Mucker et al.   Scientific Reports

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

(2019) Nurgun Kose et al.   Science Immunology

Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease

(2018) Eric M. Mucker et al.   PLoS Neglected Tropical Diseases

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus

(2016) Karuppiah Muthumani et al.   JOURNAL OF INFECTIOUS DISEASES

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

(2015) Seleeke Flingai et al.   Scientific Reports

Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease

(2015) Eric M. Mucker et al.   PLoS One

A Hantavirus Pulmonary Syndrome (HPS) DNA Vaccine Delivered Using a Spring-powered Jet Injector Elicits a Potent Neutralizing Antibody Response in Rabbits and Nonhuman Primates

(2014) Steve Kwilas et al.   CURRENT GENE THERAPY

Immunogenicity of mAbs in non-human primates during nonclinical safety assessment

(2013) Peter J.K. van Meer et al.   mAbs

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

(2013) Kar Muthumani et al.   Human Vaccines & Immunotherapeutics

Side-by-Side Comparison of Gene-Based Smallpox Vaccine with MVA in Nonhuman Primates

(2012) Joseph W. Golden et al.   PLoS One

Protection of Rabbits and Immunodeficient Mice against Lethal Poxvirus Infections by Human Monoclonal Antibodies

(2012) Lindsay Crickard et al.   PLoS One

The strategic use of novel smallpox vaccines in the post-eradication world

(2011) Joseph W Golden et al.   Expert Review of Vaccines

Passive Immunotherapies Protect WRvFire and IHD-J-Luc Vaccinia Virus-Infected Mice from Lethality by Reducing Viral Loads in the Upper Respiratory Tract and Internal Organs

(2011) M. Zaitseva et al.   JOURNAL OF VIROLOGY

Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease

(2011) Joseph W Golden et al.   Virology Journal

Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections

(2010) Yuhong Xiao et al.   Viruses-Basel

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS