A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Monoclonal Antibodies for Emerging Infectious Diseases — Borrowing from History

(2018) Hilary D. Marston et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti–CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo

(2018) Elizabeth K. Duperret et al.   CANCER RESEARCH

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics

(2018) Makan Khoshnejad et al.   MOLECULAR THERAPY

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

(2018) Ami Patel et al.   Cell Reports

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

(2017) Jonathan J. Miner et al.   Science Translational Medicine

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Long-term sequelae of chikungunya virus disease: A systematic review

(2017) Mariëlle van Aalst et al.   Travel Medicine and Infectious Disease

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques

(2017) Rebecca Broeckel et al.   PLoS Neglected Tropical Diseases

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters

(2017) Oliver F. Brandenberg et al.   PLoS Pathogens

IgG Fc engineering to modulate antibody effector functions

(2017) Xinhua Wang et al.   Protein & Cell

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

(2017) Gustaf Lindgren et al.   Frontiers in Immunology

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

(2017) Sarah T. C. Elliott et al.   npj Vaccines

An overview on safety of monoclonal antibodies

(2016) Andrea Matucci et al.   Current Opinion in Allergy and Clinical Immunology

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus

(2016) Karuppiah Muthumani et al.   JOURNAL OF INFECTIOUS DISEASES

Epidemiology of Chikungunya in the Americas

(2016) Sergio Yactayo et al.   JOURNAL OF INFECTIOUS DISEASES

Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence

(2016) David W. Hawman et al.   Cell Reports

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress

(2015) Julie M. Fox et al.   CELL

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

(2015) Scott A. Smith et al.   Cell Host & Microbe

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

(2014) Alejandro B Balazs et al.   NATURE MEDICINE

Arrival of Chikungunya Virus in the New World: Prospects for Spread and Impact on Public Health

(2014) Scott C. Weaver   PLoS Neglected Tropical Diseases

Chikungunya virus: an update on antiviral development and challenges

(2013) Parveen Kaur et al.   DRUG DISCOVERY TODAY

Reovirus Cell Entry Requires Functional Microtubules

(2013) B. A. Mainou et al.   mBio

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

(2013) Kar Muthumani et al.   Human Vaccines & Immunotherapeutics

Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

(2013) Pankaj Pal et al.   PLoS Pathogens

A Mouse Model of Chikungunya Virus–Induced Musculoskeletal Inflammatory Disease

(2011) Thomas E. Morrison et al.   AMERICAN JOURNAL OF PATHOLOGY

Chimeric Chikungunya Viruses Are Nonpathogenic in Highly Sensitive Mouse Models but Efficiently Induce a Protective Immune Response

(2011) E. Wang et al.   JOURNAL OF VIROLOGY

Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling

(2011) Charalambos D. Partidos et al.   VACCINE

Chikungunya Virus Arthritis in Adult Wild-Type Mice

(2010) J. Gardner et al.   JOURNAL OF VIROLOGY

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005–2006 outbreak on Réunion

(2008) A. ECONOMOPOULOU et al.   EPIDEMIOLOGY AND INFECTION

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

(2008) Thérèse Couderc et al.   PLoS Pathogens