Novel insights into the interaction between N6-methyladenosine modification and circular RNA

Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies

(2021) Sumeng Wang et al.   Molecular Cancer

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

(2021) Botai Li et al.   Nature Communications

CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129

(2021) Zhanqin Zhang et al.   Cell Death & Disease

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

(2021) Fanwu Chi et al.   Frontiers in Oncology

circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426

(2021) Zhen Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA

(2021) Benyu Liu et al.   Cellular & Molecular Immunology

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma

(2021) Chenyu Ding et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression

(2021) Fei Xie et al.   Molecular Cancer

N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway

(2021) Ping Wu et al.   Cell Death & Disease

HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein

(2021) Yan Li et al.   Advanced Science

Novel circGFRα1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14

(2021) Xiaoyong Li et al.   Frontiers in Cell and Developmental Biology

RNA methylation in mammalian development and cancer

(2021) Peizhe Song et al.   CELL BIOLOGY AND TOXICOLOGY

m6A modification of circHPS5 facilitates cytoplasmic export and promotes hepatocellular carcinoma progression by enhancing HMGA2 expression

(2021) Dawei Rong et al.   Molecular Therapy-Nucleic Acids

Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer

(2021) Wenjie Wei et al.   CANCER RESEARCH

N6-methyladenosine modification of FAAH mRNA in circSTAG1-regulated astrocyte dysfunction and depressive-like behaviors

(2020) Rongrong Huang et al.   BIOLOGICAL PSYCHIATRY

Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension

(2020) Hua Su et al.   BMC GENOMICS

m6A-dependent biogenesis of circular RNAs in male germ cells

(2020) Chong Tang et al.   CELL RESEARCH

Level of N6-Methyladenosine in Peripheral Blood RNA: A Novel Predictive Biomarker for Gastric Cancer

(2020) Lichen Ge et al.   CLINICAL CHEMISTRY

Exosomal Non Coding RNA in LIQUID Biopsies as a Promising Biomarker for Colorectal Cancer

(2020) Amro Baassiri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

(2020) Xu Liu et al.   Science China-Life Sciences

Novel insights into m6A modification in circular RNA and implications for immunity

(2020) Arumugam Paramasivam et al.   Cellular & Molecular Immunology

Modulation of circRNA Metabolism by m6A Modification

(2020) Gaia Di Timoteo et al.   Cell Reports

Translatable circRNAs and lncRNAs: Driving mechanisms and functions of their translation products

(2020) Shan Kong et al.   CANCER LETTERS

Epstein–Barr virus‐derived circular RNA LMP 2A induces stemness in EBV ‐associated gastric cancer

(2020) Li‐ping Gong et al.   EMBO REPORTS

RNA N6-methyladenosine modification is required for miR-98/MYCN axis-mediated inhibition of neuroblastoma progression

(2020) Junmei Cheng et al.   Scientific Reports

IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome

(2020) Min Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Circular RNAs in Immune Response and Viral Infection

(2020) Lichong Yan et al.   TRENDS IN BIOCHEMICAL SCIENCES

N 6 ‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus ‐associated hepatocellular carcinoma via sponging miR ‐1305

(2020) Xi Rao et al.   IUBMB LIFE

G protein‐coupled oestrogen receptor promotes cell growth of non‐small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling

(2020) Yi Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

(2020) Junjie Xu et al.   Molecular Cancer

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

Widespread and Functional RNA Circularization in Localized Prostate Cancer

(2019) Sujun Chen et al.   CELL

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

(2019) Chu-Xiao Liu et al.   CELL

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

(2019) Nan Wu et al.   CELL DEATH AND DIFFERENTIATION

Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer

(2019) Ke Wu et al.   Molecular Cancer

The Translational Landscape of the Human Heart

(2019) Sebastiaan van Heesch et al.   CELL

Past, present, and future of circ RNA s

(2019) Ines Lucia Patop et al.   EMBO JOURNAL

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice

(2019) Xia Chen et al.   RNA Biology

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus

(2019) Jiawei Zhao et al.   Nature Communications

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

Therapeutic targeting of circ‐ CUX 1 / EWSR 1/ MAZ axis inhibits glycolysis and neuroblastoma progression

(2019) Huanhuan Li et al.   EMBO Molecular Medicine

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

(2019) Yuanhui Mao et al.   Nature Communications

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer

(2018) Shuangyan Tan et al.   Molecular Cancer

The Biogenesis, Functions, and Challenges of Circular RNAs

(2018) Xiang Li et al.   MOLECULAR CELL

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

(2018) Benoit P Nicolet et al.   NUCLEIC ACIDS RESEARCH

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

(2018) Honghui Ma et al.   Nature Chemical Biology

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs

(2018) Zhuojia Chen et al.   NUCLEIC ACIDS RESEARCH

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma

(2018) Xiao Zhang et al.   Cell Death & Disease

Circular RNAs as Therapeutic Agents and Targets

(2018) Lesca M. Holdt et al.   Frontiers in Physiology

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

(2017) Xiang Li et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

Detecting RNA modifications in the epitranscriptome: predict and validate

(2017) Mark Helm et al.   NATURE REVIEWS GENETICS

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells

(2017) Yuko Ueda et al.   Scientific Reports

RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

(2016) Atsushi Tanabe et al.   CANCER LETTERS

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

(2016) Jlenia Guarnerio et al.   CELL

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

(2016) Xiao-Ou Zhang et al.   GENOME RESEARCH

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

The biogenesis and emerging roles of circular RNAs

(2016) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Exon Skipping Is Correlated with Exon Circularization

(2015) Steven Kelly et al.   JOURNAL OF MOLECULAR BIOLOGY

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

(2015) Yehoshua Enuka et al.   NUCLEIC ACIDS RESEARCH

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rolling Circle Translation of Circular RNA in Living Human Cells

(2015) Naoko Abe et al.   Scientific Reports

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Biogenesis, identification, and function of exonic circular RNAs

(2015) Iju Chen et al.   Wiley Interdisciplinary Reviews-RNA

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

A View of Pre-mRNA Splicing from RNase R Resistant RNAs

(2014) Hitoshi Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

(2014) Andrew D. Bosson et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Circular RNA Is Expressed across the Eukaryotic Tree of Life

(2014) Peter L. Wang et al.   PLoS One

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

Circular RNAs: diversity of form and function

(2014) Erika Lasda et al.   RNA

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

(2010) A. Harashima et al.   GENES & DEVELOPMENT