Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma

Hyperglycaemia‐induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS‐mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein

(2021) Tehreem Maradagi et al.   DIABETIC MEDICINE

The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

(2020) Evhy Apryani et al.   Journal of Neuroinflammation

Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib

(2020) Zhong Yao et al.   ACS Chemical Neuroscience

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

(2020) Anna Golebiewska et al.   ACTA NEUROPATHOLOGICA

ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis Through PI3K/Akt Signaling and MAPK-dependent Focal Adhesion Disassembly

(2020) Shayi Wu et al.   CANCER RESEARCH

Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway

(2019) Shahid Alam et al.   EXPERIMENTAL CELL RESEARCH

Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells

(2019) Dongfeng Han et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling

(2019) Mingzhi Han et al.   BRAIN

Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na + /K + -ATPase α1 subunit

(2018) Yu-Long Lan et al.   BIOMEDICINE & PHARMACOTHERAPY

Resibufogenin suppresses transforming growth factor-β-activated kinase 1-mediated nuclear factor-κB activity through protein kinase C-dependent inhibition of glycogen synthase kinase 3

(2018) Lu Liu et al.   CANCER SCIENCE

The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

(2018) Davide Schiffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide

(2018) Tor‐Christian Johannessen et al.   INTERNATIONAL JOURNAL OF CANCER

Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase

(2018) Lei Chen et al.   PHYTOMEDICINE

The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

(2017) Michael V. Clausen et al.   Frontiers in Physiology

NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations

(2017) William B. Stallcup   Cancers

Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly

(2016) Peng Sun et al.   ACTA PHARMACOLOGICA SINICA

Anti-tumor activity of SL4 against breast cancer cells: induction of G2/M arrest through modulation of the MAPK-dependent p21 signaling pathway

(2016) Li-Hui Wang et al.   Scientific Reports

Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase

(2016) Yoko Ono et al.   Scientific Reports

Sp1 regulates Raf/MEK/ERK-induced p21CIP1 transcription in TP53-mutated cancer cells

(2015) Mansi Karkhanis et al.   CELLULAR SIGNALLING

Dual inhibition of Cdc2 protein kinase activation during apoptosis inXenopusegg extracts

(2015) Yuichi Tsuchiya et al.   FEBS Journal

pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis

(2015) K. Sodhi et al.   Science Advances

High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2014) R. Stupp et al.   ANNALS OF ONCOLOGY

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Inhibiting Na+/K+ ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca2+ Cycling and Automaticity in Guinea Pig Cardiomyocytes

(2014) Qince Li et al.   PLoS One

Resibufogenin and Cinobufagin Activate Central Neurons through an Ouabain-Like Action

(2014) Ze-Jun Wang et al.   PLoS One

Emerging Therapies for Glioblastoma

(2014) Alissa A. Thomas et al.   JAMA Neurology

Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction

(2013) Yanling Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle

(2013) Jeremy B. Chang et al.   NATURE

Current concepts and management of glioblastoma

(2011) Matthias Preusser et al.   ANNALS OF NEUROLOGY

Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway

(2011) Yinhui Dong et al.   APOPTOSIS

An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells

(2011) YuMing Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks

(2011) I. Prassas et al.   MOLECULAR CANCER THERAPEUTICS

Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons

(2011) Shuang Hao et al.   NEUROSCIENCE LETTERS

A reproducible brain tumour model established from human glioblastoma biopsies

(2010) Jian Wang et al.   BMC CANCER

Commentary on effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466)

(2010) Ute Linz   CANCER

Low-dose cardiotonic steroids increase sodium–potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia

(2009) Martin Oselkin et al.   NEUROSCIENCE LETTERS

Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets

(2009) A. Y. Bagrov et al.   PHARMACOLOGICAL REVIEWS

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Digitalis: a dangerous drug in atrial fibrillation? An analysis of the SPORTIF III and V data

(2007) K Gjesdal et al.   HEART

Effects of digoxin at low serum concentrations on mortality and hospitalization in heart failure: A propensity-matched study of the DIG trial

(2007) Ali Ahmed et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY